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Archives of Gynecology and Obstetrics

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01-09-2016 | General Gynecology

The effects of lauromacrogol injection into rat endometrial cysts: a preliminary experimental study

Authors: Wei Liu, LongXia Wang, Cui-Xia Guo

Published in: Archives of Gynecology and Obstetrics | Issue 3/2016

Abstract

Objective

To determine the effectiveness of different concentrations of lauromacrogol injections for the treatment of endometriosis in an experimental animal model and to provide an experimental basis for a pre-clinical application of the drug.

Methods

After autologous transplantation of endometrial tissue, 40 endometrial cysts were successfully established and randomly divided into three groups: a 1 % lauromacrogol injection group, a 0.5 % lauromacrogol injection group, and cysts without intervention (control group). We measured the changes in the volumes of the cysts in each group. We then compared the volumes of the endometrial implants before and after treatment and between the different groups and examined the histological findings.

Results

A significant difference in the spherical volume was found between the 1 % lauromacrogol injection group (P < 0.05). No significant difference was observed between the volume of the endometrial implants in the 0.5 % lauromacrogol injection group (P > 0.05). Regarding the histopathological observations, in the 1 % lauromacrogol injection group, the epithelia of the cystic implants had atrophied, and the glands had atrophied and were reduced in number. The surrounding stromal tissue had become loose and edematous.

Conclusions

A 1 % lauromacrogol injection produced significant regression of the endometrial foci compared with a 0.5 % lauromacrogol injection or no treatment in a rat model of endometriosis.

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Title: The effects of lauromacrogol injection into rat endometrial cysts: a preliminary experimental study
Authors: Wei Liu
LongXia Wang
Cui-Xia Guo
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 3/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-016-4095-9

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

The effects of lauromacrogol injection into rat endometrial cysts: a preliminary experimental study

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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