Top

Archives of Gynecology and Obstetrics

Published in:

Open Access 01-10-2015 | Review

Growth factors, silver dressings and negative pressure wound therapy in the management of hard-to-heal postoperative wounds in obstetrics and gynecology: a review

Authors: Paweł Jan Stanirowski, Anna Wnuk, Krzysztof Cendrowski, Włodzimierz Sawicki

Published in: Archives of Gynecology and Obstetrics | Issue 4/2015

Abstract

Purpose

The last two decades witnessed the development of numerous innovative regimens for the management of patients with abnormally healing and infected wounds. Growth factors, negative pressure wound therapy (NPWT) and antiseptic dressings containing silver are examples of methods with best documented efficacy, being widely used in the treatment of acute and chronic post-traumatic wounds, burns and ulcers of various etiology. As far as obstetrics and gynecology are concerned, prevention and treatment of infected, hard-to-heal postoperative wounds is of crucial importance. This article reviews the available literature to discuss the possibilities for use, efficacy and cost-effectiveness of growth factors, NPWT and silver dressings in the treatment of difficult-to-heal postsurgical wounds in obstetrics and gynecology.

Materials and methods

An extensive search of the English and Polish literature via PubMed and EMBASE databases was undertaken for articles published between January 1960 and April 30, 2014 to identify articles that described and assessed use, efficacy and cost-effectiveness of growth factors, silver dressings and NPWT in patients with hard-to-heal postoperative wounds following obstetric or gynecological surgery.

Conclusions

Literature review regarding the use of growth factors, NPWT and silver dressings suggests that these methods may play an important role in the management of wounds after invasive obstetric and gynecological procedures. Obese patients, patients after vulvectomy or prior radiation therapy may benefit most, however, due to non-numerous randomized reports, prospective studies on the use of above-mentioned methods in the treatment of postsurgical wounds following obstetric and gynecological interventions are required.

Jamie W, Duff P (2003) Preventing infections during elective C/S and abdominal hysterectomy. Contemp Obstet Gynecol 48:60–69

Kamat AA, Brancazio L, Gibson M (2000) Wound infection in gynecologic surgery. Infect Dis Obstet Gynecol 8(5–6):230–234PubMedCentralCrossRefPubMed

Soper DE, Bump RC, Hurt WG (1995) Wound infection after abdominal hysterectomy: effect of the depth of subcutaneous tissue. Am J Obstet Gynecol 173(2):465–469CrossRefPubMed

Antonsen SL, Meyhoff CS, Lundvall L, Hogdal C (2010) Surgical-site infections and postoperative complications: agreement between the Danish Gynecological Cancer Database and a randomized clinical trial. Acta Obstet Gynecol Scand 90:72–76CrossRefPubMed

Nilsson L, Wodlin NB, Kjølhede P (2012) Risk factors for postoperative complications after fast track abdominal hysterectomy. Aust N Z J Obstet Gynaecol 52(2):113–120CrossRefPubMed

Garry R, Fountain J, Mason S, Hawe J, Napp V, Abbott J, Clayton R, Philips G, Whittaker M, Lilford R, Bridgman S, Brown J (2004) The eVALuate study: two parallel, randomised trials one comparing laparoscopic with abdominal hysterectomy, the other comparing laparoscopic with vaginal hysterectomy. BMJ 328:129–133PubMedCentralCrossRefPubMed

Yerushalmy A, Reches A, Lessing JB, Schechner V, Carmeli Y, Grisaru D (2008) Characteristics of microorganisms cultured from infected wounds post-hysterectomy. Eur J Obstet Gynecol Reprod Biol 141(2):169–172CrossRefPubMed

Parrott T, Evans AJ, Lowes A, Denmi K (1989) Infection following caesarean section. J Hosp Infect 13(4):349–354CrossRefPubMed

Hadar E, Melamed N, Tzadikevitch-Geffen K, Yogev Y (2011) Timing and risk factors of maternal complications of cesarean section. Arch Gynecol Obstet 283(4):735–741CrossRefPubMed

10.

Wloch C, Wilson J, Lamagni T, Harrington P, Charlett A, Sheridan E (2012) Risk factors for surgical site infection following caesarean section in England: results from a multicenter cohort study. BJOG 119(11):1324–1333CrossRefPubMed

11.

Thurman A, Anca Y, White C, Soper DE (2010) Post-cesarean delivery infectious morbidity: focus on preoperative antibiotics and methicillin-resistant Staphylococcus aureus. Am J Infect Control 38(8):612–616CrossRefPubMed

12.

Nice C, Feeney A, Godwin P, Mohanraj M, Edwards A, Baldwin A, Choyce A, Hunt A, Kinnaird C, Maloney M, Anderson W, Campbell L (1996) A prospective audit of wound infections rates after caesarean section in five West Yorkshire hospitals. J Hosp Infect 33(1):55–61CrossRefPubMed

13.

Wills A, Obermair A (2013) A review of complications associated with the surgical treatment of vulvar cancer. Gynecol Oncol 131(2):467–479CrossRefPubMed

14.

Falanga V (2004) Wound bed preparation: science applied to practice. European Wound Management Association (EWMA). Position Document: Wound bed preparation in practice. MEP Ltd, London

15.

Leaper DJ, Schultz G, Carville K, Fletcher J, Swanson T, Drake R (2012) Extending the TIME concept: what have we learned in the past 10 years? Int Wound J 9(Suppl 2):1–19CrossRefPubMed

16.

Rosołowska J, Rusiecka-Ziółkowska J, Fleischer M (2010) Lavasepsis and its significance in wound healing process. Zakażenia 6:7–13

17.

Winter GD (1962) Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. Nature 193:293–294CrossRefPubMed

18.

Skórkowska-Telichowska K, Bugajska-Prusak A, Pluciński P, Rybak Z, Szopa J (2009) The physiology and pathology of chronic wounds and its local treatment according to the current medical knowledge. Dermatologia Praktyczna 5:15–29

19.

Everts PA, Hoogbergen MM, Weber TA, Devilee RJ, van Monftort G, de Hingh IH (2011) Is the use of autologous platelet- rich plasma gels in gynecologic, cardiac, and general, reconstructive surgery beneficial? Curr Pharm Biotechnol 13(1):1–10

20.

Murphy PS, Evans GR (2012) Advances in wound healing: a review of current wound healing products. Plast Surg Int 2012:190436PubMedCentralPubMed

21.

Suissa D, Danino A, Nikolis A (2011) Negative-pressure therapy versus standard wound care: a metaanalysis of randomized trials. Plast Reconstr Surg 128(5):498e–503eCrossRefPubMed

22.

Blume PA, Walters J, Payne W, Ayala J, Lantis J (2008) Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers. Diabetes Care 31(4):631–636CrossRefPubMed

23.

Charles CA, Eaglestein WH (2004) Active treatments for acute and chronic wounds - growth factors. In: Rovee DT, Maibach HI (eds) The epidermis in wound healing. CRC Press, Boca Raton, pp 358–373

24.

Steed DL (1997) The role of growth factors in wound healing. Surg Clin North Am 77(3):575–586CrossRefPubMed

25.

Werner S, Grose R (2003) Regulation of wound healing by growth factors and cytokines. Physiol Rev 83(3):835–870PubMed

26.

Marx RE (2004) Platelet-Rich Plasma: evidence to support its use. J Oral Maxillofac Surg 62(4):489–496CrossRefPubMed

27.

Gowda S, Weinstein DA, Blalock TD, Gandhi K, Mast BA, Chin G, Schultz GS (2013) Topical application of recombinant platelet-derived growth factor increases the rate of healing and the level of proteins that regulate this response. Int Wound J. doi:10.1111/iwj.12165 PubMed

28.

Alsousou J, Ali A, Willett K, Harrison P (2013) The role of platelet-rich plasma in tissue regeneration. Platelets 23(3):173–182CrossRef

29.

Chan YG, Ho HK, Chen CY (1993) Abdominal hysterectomy: indications and complications. Singapore Med J 34(4):337–340PubMed

30.

Hasson HM (1993) Cervical removal at hysterectomy for benign disease: risk and benefits. J Reprod Med 38(10):781–790PubMed

31.

Betran AP, Marialdi M, Lauer JA, Bing-Shun W, Thomas J, Van Look P, Wagner M (2007) Rates of caesarean section: analysis of global, regional and national estimates. Paediatr Perinat Epidemiol 21(2):98–113CrossRefPubMed

32.

Mazurek-Kantor J, Sawicki W, Gawryluk A, Stelmachów J (2008) Analysis of cesarean section incidence in the years 1986-2007 in own material. Perinatologia, Neonatologia i Ginekolgia 1(1):44–47

33.

Mowat J, Bonnar J (1971) Abdominal wound dehiscence after caesarean section. BMJ 2(5756):256–257PubMedCentralCrossRefPubMed

34.

Olsen MA, Butler AM, Willers DM, Devkota P, Gross GA, Fraser VJ (2008) Risk factors for surgical site infection after low transverse cesarean section. Infect Control Hosp Epidemiol 29(6):477–484CrossRefPubMed

35.

Schneid-Kofman N, Sheiner E, Levy A, Holcberg G (2005) Risk factors for wound infection following cesarean deliveries. Int J Gynaecol Obstet 90(1):10–15CrossRefPubMed

36.

Shackelford DP, Fackler E, Hoffman MK, Atkinson S (2002) Use of topical recombinant human platelet-derived growth factor BB in abdominal wound separation. Am J Obstet Gynecol 186(4):701–704CrossRefPubMed

37.

Fanning J, Murrain L, Flora R, Hutchings T, Johnson JM, Fenton BW (2007) Phase I/II prospective trial of autologous platelet tissue graft in gynecologic surgery. J Minim Invasive Gynecol 14:633–637CrossRefPubMed

38.

Holschneider C, Berek J (2008) Carcinoma of the vulva. In: Berek J (ed) Ginekologia. MediPage, Warsaw

39.

Wojciechowska U, Didkowska J (2011) Malignant neoplasms morbidity and mortality rates in Poland. Polish National Cancer Database, Oncology Centre - Institute M. Skłodowska-Curie, Warsaw. http://onkologia.org.pl/raporty. Accessed 30 April 2014

40.

Way S (1960) Carcinoma of the vulva. Am J Obstet Gynecol 79:692–697PubMed

41.

Rutledge F, Smith JP, Franklin EW (1970) Carcinoma of the vulva. Am J Obstet Gynecol 106:1117–1130PubMed

42.

Podratz KC, Symmonds RE, Taylor WF, Williams TJ (1983) Carcinoma of the vulva: analysis of treatment and survival. Obstet Gynecol 61:63–74PubMed

43.

Morelli M, Rocca ML, Venturella R, Cello AD, Negro SD, Condorelli M, Dominijanni A, Zullo F (2013) Adjuvant use of platelet gel for wound breakdown prevention in advanced vulvar cancer surgery: a retrospective study. Int J of Gynecol Cancer 23(8):1490–1494CrossRef

44.

van Lindert AC, Symons EA, Damen BF, Heintz AP (1995) Wound healing after radical vulvectomy and inguino-femoral lymphadenectomy experience with granulocyte colony stimulating factor (filgrastim, r-metHuG-CSF). Eur J Obstet Gynecol Reprod Biol 62:217–219CrossRefPubMed

45.

Uyl-de Groot C, Gelderblom-den Hartog J, Derksen J et al (2004) Cost-effectiveness and quality of life of granulocyte-colony stimulating factor (filgrastim) after radical vulvectomy and bilateral inguino-femoral lymphadenectomy: results of a randomized clinical trial. Eur J Obstet Gynecol Reprod Biol 114:77–82CrossRefPubMed

46.

Kostiuchenko I, Kolker VA, Karlov VA (1986) The vacuum effect in the surgical treatment of purulent wounds. Vestink Khirurgii 9:18–21

47.

Morykwas MJ, Argenta LC, Shelton Brown EI, McGuirt W (1997) Vacuum assisted closure: a new method for wound control and treatment: animal studies and basic foundation. Ann Plast Surg 38(6):553–562CrossRefPubMed

48.

Argenta LC, Morykwas MJ (1997) Vacuum assisted closure: a new method for wound control and treatment: clinical experience. Ann Plast Surg 38(6):563–576CrossRefPubMed

49.

Argenta LC, Morykwas MJ, Marks MW, DeFranzo AJ, Molnar JA, David LR (2006) Vacuum assisted closure: state of clinic art. Plast Reconstr Surg 117(Suppl 7):S127–S142CrossRef

50.

Campbell P, Bonham P (2006) Surgical wound case studies with the Versatile 1 wound vacuum system for negative pressure wound therapy. J Wound Ostomy Continence Nurs 33:1–16CrossRef

51.

Bassetto F, Lancerotto L, Salmaso R, Pandis L, Pajardi G, Schiavon M, Tiengo C, Vindigni V (2011) Histological evolution of chronic wounds under negative pressure therapy. J Plast Reconstr Aesthet Surg 65(1):91–99CrossRefPubMed

52.

Altman A, Nelson G, Nation J, Chu P, Ghatage P (2011) Vacuum assisted wound closures in gynaecologic surgery. J Obstet Gynaecol Can 33(10):1031–1037PubMed

53.

Argenta PA, Rahaman J, Gretz HF, Nezhat F, Cohen CJ (2002) Vacuum-assisted closure in the treatment of complex gynecologic wound failures. Obstet Gynecol 99(3):497–501CrossRefPubMed

54.

Miller MS, McDaniel C (2006) Postsurgical post-hysterectomy abdominal wound dehiscence treated with negative pressure wound therapy. Int J Gynaecol Obstet 93(3):264–266CrossRefPubMed

55.

Stannard J, Zane Atkins B, O’Malley D, Singh H, Bernstein B, Fahey M, Masden D, Attinger CE (2009) Use of negative pressure therapy on closed surgical incisions: a case series. Ostomy Wound Manage 55(8):58–66PubMed

56.

Gourgiotis S, Vilias C, Benetatos C, Tsakiris A, Parisis C, Aloizos S, Salemis NS (2009) TNP-assisted fascial closure in a patient with acute abdomen and abdominal compartment syndrome. J Wound Care 18(2):65–67CrossRefPubMed

57.

Lavoie MC, Plante MM, Lemieux MC, Roberge C, Renaud MC, Gregoire J, Roy M, Sebastianelli A (2014) Extensive adipose tissue necrosis following Pfannenstiel incision for endometrial cancer. J Obstet Gynecol Can 36(3):253–257

58.

Schimp VL, Worley C, Brunello S, Levenback CC, Wolf JK, Sun CC, Bodurka DC, Ramirez PT (2004) Vacuum-assisted closure in the treatment of gynecologic oncology wound failures. Gynecol Oncol 92:586–591CrossRefPubMed

59.

Narducci F, Samouelian V, Marchaudon V, Koenig P, Fournier C, Phalippou J, Leblanc E (2012) Vacuum-assisted closure therapy in the management of patients undergoing vulvectomy. Int J Obstet Gynecol Reprod Biol 161:199–201CrossRef

60.

Riebe E, Ohlinger R, Thele F, Kohler G (2010) Polypropylene mesh implantation in combination with vacuum-assisted closure in the management of metastatic or locally recurrent vulvar cancer: case report and review of literature. Int J Gynecol Cancer 20(1):179–183CrossRefPubMed

61.

Shvartsman HS, Langstein H, Worley C, Malpica A, Ramondetta LM (2003) Use of vacuum-assisted closure device in the treatment of recurrent Paget’s disease of the vulva. Obstet Gynecol 102(5):1163–1166CrossRefPubMed

62.

Dainty LA, Bosco JJ, McBroom JW, Winter WE, Rose GS, Elkas JC (2005) Novel techniques to improve split-thickness skin graft viability during vulvo-vaginal reconstruction. Gynecol Oncol 97(3):949–952CrossRefPubMed

63.

Piovano E, Ferrero A, Ravarino N, Martra F, Modaffari P, Zola P (2011) Syringoid eccrine carcinoma: case report of a rare tumor occasionally detected in the vulva. Gynecol Oncol Case Reports 1(1):17–19CrossRef

64.

Bullough L, Wilkinson D, Burns S, Wan L (2014) Changing wound care protocols to reduce postoperative caesarean section infection and readmission. Wounds UK 10(1):72–76

65.

Mark KS, Alger L, Terplan M (2013) Incisional Negative pressure therapy to prevent wound complications following cesarean section in morbidly obese women: a pilot study. Surg Innov 21(4):345–349CrossRefPubMed

66.

Nissman KW, Nissman DB, Leighton BL, Varaday SS, Lockhart EM (2011) Necrotizing fasciitis after cesarean delivery. Anesthesiology 115(6):1301PubMed

67.

Durai R, Ng PCH, Uzkalnis A (2012) Necrotising fasciitis following a caesarean section. J Obstet Gynecol 32(1):96–98CrossRef

68.

Ottosen B, Pedersen BD (2013) Patients’ experiences of NPWT in an outpatient setting in Denmark. J Wound Care 22(4):197–206CrossRefPubMed

69.

Lewis LS, Convery PA, Bolac CS, Valea FA, Lowery WJ, Havrilesky LJ (2014) Cost of care using prophylactic negative pressure wound vacuum on closed laparotomy incisions. Gynecol Oncol 132:684–689CrossRefPubMed

70.

Beral D, Adair R, Peckham-Cooper A, Tolan D, Botterill I (2009) Lesson of the Week: chronic wound sepsis due to retained vacuum assisted closure foam. BMJ 339(7720):571–572

71.

Warriner R, Burrell R (2005) Infection and the chronic wound: a focus on silver. Adv Skin Wound Care 18(1):2–12CrossRefPubMed

72.

Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR (1999) Guideline for prevention of surgical site infection. Infect Control Hosp Epidemiol 20(4):250–278CrossRefPubMed

73.

Atiyeh BS, Costagliola M, Hayek SN, Dibo SA (2007) Effect of silver on burn wound infection control and healing: review of the literature. Burns 33(2):139–148CrossRefPubMed

74.

Fong J, Wood F (2006) Nanocrystalline silver dressings in wound management: a review. Int J Nanomed 1(4):441–449CrossRef

75.

Mooney EK, Lippitt C, Friedman J (2006) Silver dressings- safety and efficacy reports. Plast Reconstr Surg 177(2):666–669CrossRef

76.

Yin HQ, Langford R, Burrell RE (1999) Comparative evaluation of the antimicrobial activity of Acticoat antimicrobial barrier dressing. J Burn Care Rehabil 20(3):195–200CrossRefPubMed

77.

Wright JB, Lam K, Burrell RE (1998) Wound management in an era of increasing bacterial antibiotic resistance: a role for topical silver treatment. Am J Infect Control 26(6):572–577CrossRefPubMed

78.

You C, Han C, Wang X, Zheng Y, Li Q, Hu X, Sun H (2012) The progress of silver nanoparticles in the antibacterial mechanism, clinical application and cytotoxicity. Mol Biol Rep 39:9193–9201CrossRefPubMed

79.

Markowska-Sioma U (2011) Treatment of hard-to-heal wounds in gynaecology. Ginekologia i Położnictwo 22(4):55–62

80.

Connery SA, Downes KL, Young C (2012) A retrospective study evaluating silver-impregnated dressings on cesarean wound healing. Adv Skin Wound Care 25(9):414–419CrossRefPubMed

Title: Growth factors, silver dressings and negative pressure wound therapy in the management of hard-to-heal postoperative wounds in obstetrics and gynecology: a review
Authors: Paweł Jan Stanirowski
Anna Wnuk
Krzysztof Cendrowski
Włodzimierz Sawicki
Publication date: 01-10-2015
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 4/2015
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-015-3709-y

At a glance: The STEP trials

Springer Medicine

Growth factors, silver dressings and negative pressure wound therapy in the management of hard-to-heal postoperative wounds in obstetrics and gynecology: a review

Abstract

Purpose

Materials and methods

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Materials and methods

Conclusions

Please log in to get access to this content

Other articles of this Issue 4/2015

Response to: Relationship between preeclampsia, gestational hypertension, and vitamin D receptor (VDR) gene polymorphisms

The significance of a uterine rupture in subsequent births

Prognostic factors affecting cervical adenocarcinoma: 10 years experience in a single institution

Maternal anthropometric measurements as predictors of low birth weight in developing and developed countries

Safety of insulin analogs during pregnancy: a meta-analysis

Revisit of risk factors for major obstetric hemorrhage: insights from a large medical center