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01-07-2014 | General Gynecology

Copeptin is associated with the severity of endometriosis

Authors: Abdullah Tuten, Mine Kucur, Metehan Imamoglu, Baris Kaya, Abdullah Serdar Acikgoz, Nevin Yilmaz, Zeynep Ozturk, Mahmut Oncul

Published in: Archives of Gynecology and Obstetrics | Issue 1/2014

Abstract

Purpose

Endometriosis is defined as the presence of endometrial glands and stroma in ectopic locations and may be associated with local and systemic inflammatory processes. Copeptin is elevated in acute and chronic inflammation conditions. The aim of the present study was to determine whether serum copeptin levels were altered in women with endometriosis and played a role in the pathophysiology of the disease.

Methods

A total of 86 women were recruited for this case–control study. 50 patients with surgically proven endometriosis were included, while 36 patients without endometriosis comprised the control group. Patients were classified as having minimal, mild, moderate and severe disease in accordance with American Society of Reproductive Medicine revised classification. Two subgroups were formed by combining patients with minimal and mild disease and with moderate and severe disease (Stage 1–2, stage 3–4; respectively). Levels of copeptin, tumor markers (CA-125, CA-19-9, CA-15-3) and C-reactive protein in serum were measured.

Results

Serum copeptin, CA-125, CA-15-3 and CA-19-9 levels were higher in the endometriosis group (p: 0.002; 0.001; 0.017; 0.015; respectively). Copeptin and CA-19-9 levels were significantly higher in stage 3–4 group as compared to stage 1–2 group (p: 0.004; 0.036 respectively). Serum copeptin levels were positively correlated with stage of the disease and size of endometriomas. ROC analysis revealed that CA-125 had the highest AUC for predicting endometriosis (0.938; 95 % confidence interval 0.882–0.993; p: 0.001).

Conclusions

Serum copeptin levels were significantly higher in patients with endometriosis as compared to healthy controls. Moreover, severity of the disease was correlated with serum copeptin levels.

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Title: Copeptin is associated with the severity of endometriosis
Authors: Abdullah Tuten
Mine Kucur
Metehan Imamoglu
Baris Kaya
Abdullah Serdar Acikgoz
Nevin Yilmaz
Zeynep Ozturk
Mahmut Oncul
Publication date: 01-07-2014
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 1/2014
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-014-3163-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Copeptin is associated with the severity of endometriosis

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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