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Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 6/2013

01-12-2013 | Reproductive Medicine

Comparison of GnRH agonist and antagonist protocols in normoresponder patients who had IVF-ICSI

Authors: Mustafa Kara, Turgut Aydin, Turhan Aran, Nurettin Turktekin, Betul Ozdemir

Published in: Archives of Gynecology and Obstetrics | Issue 6/2013

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Abstract

Purpose

To measure the estradiol (E2) and progesterone levels on day of human chorionic gonadotropin (hCG) and to assess follicular development, pregnancy rates and IVF-ICSI outcomes comparing gonadotropin releasing hormone (GnRH) agonist and antagonist protocols.

Methods

A total 195 women were included in the study. The patients were treated with agonist or antagonist protocol according to the clinician’s and patient’s preference. GnRH agonist and antagonists were administered to 77 and 118 patients, respectively.

Results

Retrieved oocyte number (RON), metaphase two oocyte number (MON), E2 and progesteron levels on day of hCG, and fertilization rate were significantly higher in agonist group than antagonist group (p < 0.05). Implantation rate (IR), clinical pregnancy rate (CPR), and ongoing pregnancy rate (OPR) were significantly higher in antagonist group than agonist group (p < 0.05). However, there was no significant difference between both groups in relation with total follicle stimulating hormone (FSH).

Conclusion

GnRH agonist treatment seems to be associated with higher serum E2 and progesterone levels and resulted in lower pregnancy rates than antagonist treatment.
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Metadata
Title
Comparison of GnRH agonist and antagonist protocols in normoresponder patients who had IVF-ICSI
Authors
Mustafa Kara
Turgut Aydin
Turhan Aran
Nurettin Turktekin
Betul Ozdemir
Publication date
01-12-2013
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 6/2013
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-013-2903-z

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