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01-11-2013 | Maternal-Fetal Medicine

Erythrocyte folate content and serum folic acid and homocysteine levels in preeclamptic primigravidae teenagers living at high altitude

Authors: Pablo Yanez, Carlos J. Vásquez, Luis Rodas, Augusto Durán, Peter Chedraui, Kim H. Liem, Faustino R. Pérez-López, Enrique Teran

Published in: Archives of Gynecology and Obstetrics | Issue 5/2013

Abstract

Objective

To measure erythrocyte folate content and serum folic acid and homocysteine (Hcy) levels in preeclamptic primigravidae teenagers living at high altitude.

Methods

Measured analytes were compared to those found in normal teen controls.

Results

Teenagers complicated with preeclampsia displayed significantly lower hematocrit and erythrocyte folic acid levels with higher serum Hcy levels as compared to controls (36.40 ± 4.90 vs. 38.99 ± 2.89 %, 493.80 ± 237.30 vs. 589.90 ± 210.60 ng/mL, and 7.29 ± 2.52 vs. 5.97 ± 1.41 μmol/L, respectively, p < 0.05). There was a non-significant trend for lower serum folic acid levels among preeclampsia teenagers. Serum and erythrocyte folic acid levels positively correlated in preeclampsia teenagers, and levels of both analytes inversely correlated with Hcy levels.

Conclusion

This pilot study found that teenagers complicated with preeclampsia living at higher altitude displayed lower erythrocyte folate content in addition to higher serum Hcy levels. More research is warranted to determine the clinical implications of these findings.

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Title: Erythrocyte folate content and serum folic acid and homocysteine levels in preeclamptic primigravidae teenagers living at high altitude
Authors: Pablo Yanez
Carlos J. Vásquez
Luis Rodas
Augusto Durán
Peter Chedraui
Kim H. Liem
Faustino R. Pérez-López
Enrique Teran
Publication date: 01-11-2013
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 5/2013
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-013-2851-7

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Erythrocyte folate content and serum folic acid and homocysteine levels in preeclamptic primigravidae teenagers living at high altitude

Abstract

Objective

Methods

Results

Conclusion

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Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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