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Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 5/2011

01-05-2011 | General gynecology

Genitourinary prolapse and joint hypermobility are associated with altered type I and III collagen metabolism

Authors: E. Knuuti, S. Kauppila, V. Kotila, J. Risteli, Ritva Nissi

Published in: Archives of Gynecology and Obstetrics | Issue 5/2011

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Abstract

Purpose

The aim of this study was to determine whether benign joint hypermobility (BJH) is associated with urogenital prolapse and altered collagen metabolism.

Methods

43 postmenopausal women with previous vaginal hysterectomy operated due to genitourinary prolapse were recruited. Each patient was also evaluated for joint hypermobility. The collagen metabolism was studied measuring serum concentrations of type I and III procollagen aminoterminal propeptides and trivalently cross-linked carboxyterminal telopeptide of type I collagen.

Results

Clinical joint hypermobility was found in 35% patients. Women with joint hypermobility had higher concentration of aminoterminal propeptide for type I procollagen and the values were statistically significant (P < 0.0178). Recurrent prolapse was found in 47% of the patients with BJH as compared to non-hypermobile group (25%). In this subgroup the results were statistically significant (P < 0.0085) for type III collagen. Also, the mean serum concentration for type III procollagen was significantly increased above the reference limit.

Conclusions

Women with joint hypermobility have more recurrent genital prolapse as compared to women with normal joint mobility. Plain hypermobility was associated with higher concentrations for type I procollagen. Patients with recurrent prolapse and joint hypermobility have significantly high concentrations for type III procollagen.
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Metadata
Title
Genitourinary prolapse and joint hypermobility are associated with altered type I and III collagen metabolism
Authors
E. Knuuti
S. Kauppila
V. Kotila
J. Risteli
Ritva Nissi
Publication date
01-05-2011
Publisher
Springer-Verlag
Published in
Archives of Gynecology and Obstetrics / Issue 5/2011
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-010-1518-x

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