Top

Archives of Gynecology and Obstetrics

Published in:

01-03-2009 | Original Article

Cervical phosphorylated insulin-like growth factor binding protein-1 in prediction of preterm delivery

Authors: Ozlem Altinkaya, Tayfun Gungor, Mustafa Ozat, Nuri Danisman, Leyla Mollamahmutoglu

Published in: Archives of Gynecology and Obstetrics | Issue 3/2009

Abstract

Background

The aim of this study was to evaluate the phosphorylated isoform of insulin-like growth factor binding protein-1 (phIGFBP-1) in endocervical secretions as a predictor of preterm delivery in symptomatic and asymptomatic pregnant women.

Methods

The study included 105 patients between 24 and 34 weeks’ gestation with uterine contractions and 73 controls. Ph IGFBP-1 in cervical secretions was assessed in all patients by using a qualitative, immunochromatographic one-step dipstick test. Data analysis included Student’s test, Chi-Square, Fisher’s exact test and Kruskal Wallis variance analysis.

Results

Preterm birth rate was 19.04% (20/105) in the study group. Of the 25 patients with a positive phIGFBP-1 test, mean gestational age at delivery was 32.8 ± 3.8, whereas of the 80 patients with a negative phIGFBP-1 test mean gestational age at delivery was 37.8 ± 2.5, in the study group (P < 0.05). The sensitivity, specificity, positive predictive value and negative predictive value for phIGFBP-1 in symptomatic patients were 70, 87.05, 56 and 92.5%, respectively, while in asymptomatic patients they were 40, 82.35, 14.28 and 94.91%, respectively.

Conclusions

The phIGFBP-1 in cervical secretions is a potential specific marker for preterm delivery occurring before 37 weeks. Also cervical detection of phIGFBP-1 by immunochromotography is a rapid and easily applicable test that highly predicts preterm delivery.

Akercan F, Kazandi M, Sendag F, Cirpan T, Mgoyi L, Terek MC et al (2004) Value of cervical insulin-like growth factor binding protein-1 in the prediction of preterm labor. J Reprod Med 49(5):368–372PubMed

De Carvalho MH, Bittar RE, Brizot Mde L, Bicudo C, Zugaib M (2005) Prediction of preterm delivery in the second trimester. Obstet Gynecol 105(3):532–536PubMed

Elizur SE, Yinon Y, Epstein GS, Seidman DS, Schiff E, Sivan E (2005) Insulin-like growth factor binding protein-1 detection in preterm labor:evaluation of a bed-side test. Am J Perinatol 22(6):305–309. doi:10.1055/s-2005-870895 PubMedCrossRef

Eroglu D, Yanik F, Oktem M, Zeyneloglu HB, Kuscu E (2007) Prediction of preterm delivery among women with threatened preterm labor. Gynecol Obstet Invest 64(2):109–116. doi:10.1159/000100120 PubMedCrossRef

Fuchs IB, Henrich W, Osthues S, Dudenhausen JW (2004) Sonographic cervical length in singleton pregnancies with intact membranes presenting with threatened preterm labor. Ultrasound Obstet Gynecol 24(5):554–557. doi:10.1002/uog.1714 PubMedCrossRef

Goepfert AR, Goldenberg RL, Mercer B, Iams J, Meis P, Moawad A et al (2000) The preterm prediction study: quantitative fetal fibronectin values and the prediction of the spontaneous preterm birth. The National Institute of Child Health and Human Development Maternal Fetal Medicine Units Network. Am J Obstet Gynecol 183(6):1480–1483. doi:10.1067/mob.2000.107067 PubMedCrossRef

Goldenberg RL, Mercer BM, Iams JD, Moawad AH, Meis PJ, Das A et al (1997) The preterm prediction study: patterns of cervicovaginal fetal fibronectin as predictors of spontaneous preterm delivery. The National Institute of Child Health and Human Development Maternal Fetal Medicine Units Network. Am J Obstet Gynecol 177(1):8–12. doi:10.1016/S0002-9378(97)70430-7 PubMedCrossRef

Iams JD, Goldenberg RL, Mercer BM, Moawad A, Thom E, Meis PJ et al (1998) The preterm prediction study: recurrence risk of spontaneous preterm birth. National Institute of Child Health and Human Development Maternal Fetal Medicine Units Network. Am J Obstet Gynecol 178(5):1035–1040. doi:10.1016/S0002-9378(98)70544-7 PubMedCrossRef

Kekki M, Kurki T, Kärkkäinen T, Hiilesmaa V, Paavonen J, Rutanen EM (2001) Insulin-like growth factor binding protein-1 in cervical secretion as a predictor of preterm delivery. Acta Obstet Gynecol Scand 80(6):546–551. doi:10.1034/j.1600-0412.2001.080006546.x PubMedCrossRef

10.

King JF, Grant A, Keirse MJ, Chalmers I (1988) Beta-mimetics in preterm labor: an overview of the randomized controlled trials. Br J Obstet Gynaecol 95(3):211–222PubMed

11.

Kurkinen-Räty M, Ruokonen A, Vuopala S, Koskela M, Rutanen EM, Kärkkäinen T et al (2001) Combination of cervical interleukin-6 aand 8, phosphorylated insulin-like growth factor binding protein-1 and transvaginal cervical ultrasonography in assessment of the risk of preterm birth. BJOG 108(8):875–881. doi:10.1111/j.1471-0528.2001.00199.x PubMedCrossRef

12.

Leitich H (2005) Controversies in diagnosis of preterm labor. BJOG 112(Suppl 1):61–63. doi:10.1111/j.1471-0528.2005.00587.x PubMed

13.

Lembet A, Eroglu D, Ergin T, Kuscu E, Zeyneloglu H, Batioglu S et al (2002) New rapid bed-side test to predict preterm delivery: phosphorylated insulin-like growth factor binding protein-1 in cervical secretions. Acta Obstet Gynecol Scand 81(8):706–712. doi:10.1034/j.1600-0412.2002.810804.x PubMedCrossRef

14.

Main DM, Richardson D, Gabbe SG, Strong S, Weller SC (1987) Prospective evaluation of a risk scoring system for predicting preterm delivery in black inner city women. Obstet Gynecol 69(1):61–66PubMed

15.

Malak TM, Sizmur F, Bell SC, Taylor DJ (1996) Fetal fibronectin in cervicovaginal secretions as a predictor of preterm birth. Br J Obstet Gynaecol 103(7):648–653PubMed

16.

Martina NA, Kim E, Chitkara U, Wathen NC, Chard T, Giudice LC (1997) Gestational age dependent expression of insulin-like growth factor binding protein-1 (IGFBP-1) phosphoisoforms in human extraembryonic cavities, maternal serum and decidua suggests decidua as the primary source of IGFBP-1 in these fluids during early pregnancy. J Clin Endocrinol Metab 82(6):1894–1898. doi:10.1210/jc.82.6.1894 PubMedCrossRef

17.

Paternoster DM, Muresan D, Vitulo A, Serena A, Battagliarin G, Dell’avanzo M, Nicolini U (2007) Cercical phIGFBP-1 in the evaluation of the risk of preterm delivery. Acta Obstet Gynecol Scand 86(2):151–155. doi:10.1080/00016340600935730 PubMedCrossRef

18.

Peaceman AM, Andrews WW, Thorp JM, Cliver SP, Lukes A, Iams JD et al (1997) Fetal fibronectin as a predictor of preterm birth in patients with symptoms: a multicenter trial. Am J Obstet Gynecol 177(1):13–18. doi:10.1016/S0002-9378(97)70431-9 PubMedCrossRef

19.

Tsikouras P, Galazios G, Zalvanos A, Bouzaki A, Athanasiadis A (2007) Transvaginal sonographic assessment of the cervix and preterm labor. Clin Exp Obstet Gynecol 34(3):159–162PubMed

20.

Tsoi E, Akmal S, Rane S, Otigbah C, Nicolaides KH (2003) Ultrasound assessment of the cervical length in threatened preterm labor. Ultrasound Obstet Gynecol 21(6):552–555. doi:10.1002/uog.131 PubMedCrossRef

Title: Cervical phosphorylated insulin-like growth factor binding protein-1 in prediction of preterm delivery
Authors: Ozlem Altinkaya
Tayfun Gungor
Mustafa Ozat
Nuri Danisman
Leyla Mollamahmutoglu
Publication date: 01-03-2009
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 3/2009
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-008-0703-7

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Cervical phosphorylated insulin-like growth factor binding protein-1 in prediction of preterm delivery

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 3/2009

Peritoneal fluid and serum leptin concentrations in women with primary infertility

Esophageal carcinoma during pregnancy: a case report

Bladder injuries during cesarean section in a University Hospital: a 25-year review

Perinatal mortality: a sporadic event or a recurrent catastrophe?

Retroperitoneal adenocarcinoma of unknown origin presenting as a rare cause of obstructed labor

The sexual activity during pregnancy among a group of Iranian women