Top

Archives of Gynecology and Obstetrics

Published in:

01-02-2009 | Case Report

A rare case of coexistence of carcinoid tumor of appendix vermicularis and ileal endometriosis

Authors: Nazila Azordegan, Adel Yazdankhah, Mohammed H. Moghadasian

Published in: Archives of Gynecology and Obstetrics | Issue 2/2009

Abstract

Background

Carcinoid tumor is the most common tumor of appendix with overall good prognosis. Endometriosis is the implantation of endometrial glands and stroma outside the uterus.

Case report

We here report the coexistence of carcinoid tumor of appendix and ileal endometriosis in a 37-year-old nulliparous woman who came to the emergency room with right lower abdominal pain mimicking acute appendicitis. The main clinical and laboratory findings included fever, leukocytosis and elevated ESR. With preoperative suspicion of acute appendicitis, laparatomy was performed and revealed apparently normal looking appendix, along with a nodule in the terminal ileum. Both the appendix and ileal nodule were removed. Histological examinations revealed carcinoid tumor of appendix and ileal endometriosis. The case was discharged 4 days after surgery with no pain and symptoms and remained symptom free for the 1 year period of follow up.

Conclusion

Many cases of carcinoid tumor of the appendix and ileal endometriosis are diagnosed incidentally. Overall prognosis of these conditions is very good. Surgical treatment seems to be the best intervention for these disorders.

Addiss DG, Shaffer N, Fowler BS, Tauxe RV (1990) The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 132:910–925PubMed

Moertel CG, Dockerty MB, Judd ES (1968) Carcinoid tumors of the vermiform appendix. Cancer 21:270–278PubMedCrossRef

Connor SJ, Hanna GB, Frizelle FA (1998) Appendiceal tumors: retrospective clinicopathologic analysis of appendiceal tumors from 7, 970 appendectomies. Dis Colon Rectum 41:75–80PubMedCrossRef

Lyss AP (1988) Appendiceal malignancies. Semin Oncol 15:129–137PubMed

Sandor A, Modlin IM (1998) A retrospective analysis of 1570 appendiceal carcinoids. Am J Gastroenterol 93:422–428PubMedCrossRef

O’donnell ME, Badger SA, Beattie GC, Carson J, Garstin WI (2007) Malignant neoplasms of the appendix. Int J Colorectal Dis 22:1239–1248PubMedCrossRef

McCusker ME, Coté TR, Clegg LX, Sobin LH (2002) Primary malignant neoplasms of the appendix: a population-based study from the surveillance, epidemiology and end-results program, 1973–1998. Cancer 94:3307–3312PubMedCrossRef

Hemminki K, Li X (2001) Incidence trends and risk factors of carcinoid tumors: a nationwide epidemiologic study from Sweden. Cancer 92:2204–2210PubMedCrossRef

Anderson JR, Wilson BG (1985) Carcinoid tumours of the appendix. Br J Surg 72:545–546PubMedCrossRef

10.

Modlin IM, Lye KD, Kidd M (2003) A 5-decade analysis of 13, 715 carcinoid tumors. Cancer 97:934–959PubMedCrossRef

11.

Corpron CA, Black CT, Herzog CE, Sellin RV, Lally KP, Andrassy RJ (1995) A half century of experience with carcinoid tumors in children. Am J Surg 170:606–608PubMedCrossRef

12.

Dall’Igna P, Ferrari A, Luzzatto C, Bisogno G, Casanova M, Alaggio R, Terenziani M, Cecchetto G (2005) Carcinoid tumor of the appendix in childhood: the experience of two Italian institutions. J Pediatr Gastroenterol Nutr 40:216–219PubMedCrossRef

13.

Tchana-Sato V, Detry O, Polus M, Thiry A, Detroz B, Maweja S, Hamoir E, Defechereux T, Coimbra C, De Roover A, Meurisse M, Honoré P (2006) Carcinoid tumor of the appendix: a consecutive series from 1237 appendectomies. World J Gastroenterol 12:6699–6701PubMed

14.

Marudanayagam R, Williams GT, Rees BI (2006) Review of the pathological results of 2660 appendicectomy specimens. J Gastroenterol 41:745–749PubMedCrossRef

15.

Blair NP, Bugis SP, Turner LJ, MacLeod MM (1993) Review of the pathologic diagnoses of 2,216 appendectomy specimens. Am J Surg 165:618–620PubMedCrossRef

16.

Syracuse DC, Perzin KH, Price JB, Wiedel PD, Mesa-Tejada R (1979) Carcinod tumors of the appendix: mesoappendiceal extention and nodal metastases. Ann Surg 190:58–63PubMedCrossRef

17.

Moertel CG, Weiland LH, Nagorney DM, Dockerty MB (1987) Carcinoid tumor of the appendix: treatment and prognosis. N Engl J Med 317:1699–1701PubMed

18.

Jónsson T, Jóhannsson JH, Hallgrimsson JG (1989) Carcinoid tumors of the appendix in children younger than 16 years. A retrospective clinical and pathologic study. Acta Chir Scand 155:113–116PubMed

19.

Ridha JR, Cassaro S (2003) Acute small bowel obstruction secondary to ileal endometriosis: report of a case. Surg Today 33:944–947PubMedCrossRef

20.

Hornstein MD, Barbieri RL (1999) Endometriosis. In: Ryan Kistner’s gynecology and women’s health, 7th edn. Mosby, St. Louis, pp 492–519

21.

Croom RD 3rd, Donovan ML, Schwesinger WH (1984) Intestinal endometriosis. Am J Surg 148:660–667PubMedCrossRef

22.

Martimbeau PW, Pratt JH, Gaffey TA (1975) Small-bowel obstruction secondary to endometriosis. Mayo Clin Proc 50:239–243PubMed

23.

Kinkel K, Chapron C, Balleyguier C, Fritel X, Dubuisson JB, Moreau JF (1999) Magnetic resonance imaging characteristics of deep endometriosis. Hum Reprod 14:1080–1086PubMedCrossRef

24.

Decker D, König J, Wardelmann E, Richter O, Popat S, Wolff M, Hirner A, Ulrich U (2004) Terminal ileitis with sealed perforation—a rare complication of intestinal endometriosis: case report and short review of the literature. Arch Gynecol Obstet 269:294–298PubMedCrossRef

25.

Starzinski-Powitz A, Handrow-Metzmacher H, Kotzian S (1999) The putative role of cell adhesion molecules in endometriosis: can we learn from tumour metastasis? Mol Med Today 5:304–309PubMedCrossRef

26.

Gaetje R, Kotzian S, Herrmann G, Baumann R, Starzinski-Powitz A (1997) Nonmalignant epithelial cells, potentially invasive in human endometriosis, lack the tumor suppressor molecule E-cadherin. Am J Pathol 150:461–467PubMed

27.

Chen GT, Tai CT, Yeh LS, Yang TC, Tsai HD (2002) Identification of the cadherin subtypes present in the human peritoneum and endometriotic lesions: potential role for P-cadherin in the development of endometriosis. Mol Reprod Dev 62:289–294PubMedCrossRef

28.

Pannala R, Gafni-Kane A, Kidd M, Modlin IM (2007) An ileal endometrioma: of carcinoids and cadherin. J Gastrointest Surg 11:229–232PubMedCrossRef

29.

Yantiss RK, Clement PB, Young RH (2001) Endometriosis of the intestinal tract: a study of 44 cases of a disease that may cause diverse challenges in clinical and pathologic evaluation. Am J Surg Pathol 25:445–454PubMedCrossRef

30.

Saleh N, Daw E (1980) Endometriosis in non-gynaecological sites. Practitioner 224:1189–1195PubMed

31.

Ingerslev M (1977) Danazol: an antigonadotrophic agent in the treatment of recurrent pelvic and intestinal endometriosis. Acta Obstet Gynecol Scand 56:343–346PubMedCrossRef

Title: A rare case of coexistence of carcinoid tumor of appendix vermicularis and ileal endometriosis
Authors: Nazila Azordegan
Adel Yazdankhah
Mohammed H. Moghadasian
Publication date: 01-02-2009
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 2/2009
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-008-0660-1

At a glance: The STEP trials

Springer Medicine

A rare case of coexistence of carcinoid tumor of appendix vermicularis and ileal endometriosis

Abstract

Background

Case report

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case report

Conclusion

Please log in to get access to this content

Other articles of this Issue 2/2009

A case of benign metastasizing leiomyoma treated by surgical castration followed by an aromatase inhibitor, anastrozole

Vaginal evisceration after hysterectomy: a rare condition a gynecologist should be familiar with

Triplets on endometrial tuberculosis after two embryo transfer: a case report and the review of the literature

A heavily pretreated patient with recurrent clear cell adenocarcinoma of the ovary in whom carcinomatous peritonitis was controlled successfully by salvage therapy with gemcitabine

Can pentoxifylline improve the sperm motion and ICSI success in the primary ciliary dyskinesia?

Uterocutaneous fistula after surgical treatment of an incomplete abortion: methylene blue test to verify the diagnosis