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Archives of Gynecology and Obstetrics

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01-11-2007 | Case Report

Three synchronized neoplasms of the female genital tract: an extraordinary presentation

Authors: Tanju Pekin, Pinar Yoruk, Recep Yıldızhan, Begüm Yıldızhan, Saime Ramadan

Published in: Archives of Gynecology and Obstetrics | Issue 5/2007

Abstract

Introduction

We report a case of unusual co-existence of multiple primary neoplasms of female genital tract.

Case

A 62-year-old gravida 2, para 2 was referred with spotting and vaginal discharge for about 6 months. Fractionate curettage was performed and documented endocervical squamous cell carcinoma in situ. Subsequently total abdominal hysterectomy and bilateral salphingo-oophorectomy was performed. Final pathological report demonstrated cervical squamous cell carcinoma, right ovarian Brenner tumor, left ovarian granulosa tumor and endometrial polyps.

Discussion

Multiple primary neoplasms of female genital tract is a well-recognized yet rare occurrence. Although the presented case is probably an incidental event, the pathogenesis of the neoplastic process affecting the tissues with different embryological origin needs further research and evaluation. It is important to distinguish multiple primary neoplasms from metastatic disease because of the fact that overall survival as well as treatment would vary considerably.

Bichel P (1985) Simultaneous occurrence of a granulosa cell tumour and a serous papillary cystadenocarcinoma in the same ovary. A case report. Acta Pathol Microbiol Immunol Scand 93:175–181

Chen KT (1986) Female genital tract tumors in Peutz-Jeghers syndrome. Hum Pathol 17:858–861PubMedCrossRef

Deligdisch L, Szulman AE (1975) Multiple and multifocal carcinomas in female genital organs and breast. Gynecol Oncol 3:181–190PubMedCrossRef

Eifel P, Hendrickson M, Ross J, Ballon S, Mantinez A, Kempson R (1982) Simultaneous presentation of carcinoma involving the ovary and endometrium. Cancer 50:163–170PubMedCrossRef

Isin Dogan Ekici A, Kucukali T, Coskun Salman M, Ayhan A (2006) Triple simultaneous primary gynecological malignancies in a 56-year-old patient. Int J Gynecol Cancer 16:1947–1950PubMedCrossRef

Kaminski PF, Norris HJ (1984) Coexistence of ovarian neoplasms and endocervical adenocarcinoma. Obstet Gynecol 64:553–556PubMed

Livolsi VA, Merino MJ, Schwartz PE (1983) Coexistent endocervical adenocarcinoma and mucinous adenocarcinoma of ovary: a clinicopathologic study of four cases. Int J Gynecol Pathol 1:391–402PubMed

Mai KT, Yazdi HM, Bertrand MA, LeSaux N, Cathcart LL (1996) Bilateral primary ovarian squamous cell carcinoma associated with human papilloma virus infection and vulvar and cervical intraepithelial neoplasia. A case report with review of the literature. Am J Surg Pathol 20:767–772PubMedCrossRef

Mangili G, Taccagni G, Garavaglia E, Carnelli M, Montoli S (2004) An unusual admixture of neoplastic and metaplastic lesions of the female genital tract in the Peutz-Jeghers Syndrome. Gynecol Oncol 92:337–342PubMedCrossRef

10.

Manolitsas TP, Lanham SA, Hitchcock A, Watson RH (1998) Synchronous ovarian and cervical squamous intraepithelial neoplasia: an analysis of HPV status. Gynecol Oncol 70:428–431PubMedCrossRef

11.

Matlock DL, Salem FA, Charles EH, Savage EW (1982) Synchronous multiple primary neoplasia of the upper female tract. Gynecol Oncol 13:271–277PubMedCrossRef

12.

McKenna M, Kenny B, Dorman G, McCluggage WG (2005) Combined adult granulosa cell tumor and mucinous cystadenoma of the ovary: granulosa cell tumor with heterologous mucinous elements. Int J Gynecol Pathol 24:224–227PubMedCrossRef

13.

Milano CT, Deppe G, Deligdisch L, Cohen CJ (1980) Multiple primary neoplasms of the upper female genital tract. Gynecol Oncol 9:120–124PubMedCrossRef

14.

Ozbey C, Erdogan G, Pestereli HE, Simsek T, Karaveli S (2005) Serous papillary adenocarcinoma and adult granulosa cell tumor in the same ovary. An unusual case. APMIS 113:713–715PubMedCrossRef

15.

Papageorgiou T, Stratakis CA (2002) Ovarian tumors associated with multiple endocrine neoplasias and related syndromes (Carney complex, Peutz-Jeghers syndrome, von Hippel-Lindau disease, Cowden’s disease). Int J Gynecol Cancer 12:337–347PubMedCrossRef

16.

Price A, Russell P, Elliott P, Bannatyne P (1990) Composite mucinous and granulosa-cell tumor of ovary: case report of a unique neoplasm. Int J Gynecol Pathol 9:372–378PubMedCrossRef

17.

Ree YS, Cho SH, Kim SR, Cho SH, Kim KT, Park MH (2003) Synchronous primary endometrial and ovarian cancer with three different histologic patterns: a case report. Int J Gynecol Cancer 13:678–682PubMedCrossRef

18.

Saraiva J, Cunha F, Passos MJ, Dos Reis IS, Francisca A, Pereira A, Cabral I, Retto H (1995) Primary malignant neoplasms of the female genitalia. Acta Med Port 8:585–588PubMed

19.

Seldenrijk CA, Willig AP, Baak JP, Kuhnel R, Rao BR, Burger CW, van der Harten JJ, Dijkhuizen GH, Meijer CJ (1986) Malignant Brenner tumor. A histologic, morphometrical, immunohistochemical, and ultrastructural study. Cancer 58:754–760PubMedCrossRef

20.

Shimada M, Kigawa J, Nishimura R, Yamaguchi S, Kuzuya K, Nakanishi T, Suzuki M, Kita T, Iwasaka T, Terakawa N (2006) Ovarian metastasis in carcinoma of the uterine cervix. Gynecol Oncol 101:234–237PubMedCrossRef

21.

Song SH, Lee JK, Saw HS, Choi SY, Koo BH, Kim A, Yeom BW, Kim I (2006) Peutz-Jeghers Syndrome with multiple genital tract tumors and breast cancer: a case report with a review of literatures. J Korean Med Sci 21:752–757PubMed

22.

Stiller RJ, Gondos B, Hoffman JS, O’Regan PT, Curry SL (1986) Multiple primary neoplasms of the female genital tract. Conn Med 50:649–651PubMed

23.

Waxman M, Damjanov I, Alpert L, Sardinsky T (1981) Composite mucinous ovarian neoplasms associated with Sertoli–Leydig and carcinoid tumors. Cancer 47:2044–2052PubMedCrossRef

24.

Westerman AM, Wilson JH (1999) Peutz-Jeghers syndrome: risks of a hereditary condition. Scand J Gastroenterol Suppl 230:64–70PubMedCrossRef

25.

Woodruff JD, Julian CG (1969) Multiple malignancy in the upper genital tract. Am J Obstet Gynecol 103:810–822PubMed

26.

Yang SW, Cho MY, Jung SH, Lee KG, Cha DS, Kim KR (2001) Mucinous cystadenoma coexisting with stromal tumor with minor sex-cord elements of the ovary: a case report. J Korean Med Sci 16:237–240PubMed

27.

Young RH, Scully RE (1988) Mucinous ovarian tumors associated with mucinous adenocarcinomas of the cervix. A clinicopathological analysis of 16 cases. Int J Gynecol Pathol. 7:99–111PubMedCrossRef

Title: Three synchronized neoplasms of the female genital tract: an extraordinary presentation
Authors: Tanju Pekin
Pinar Yoruk
Recep Yıldızhan
Begüm Yıldızhan
Saime Ramadan
Publication date: 01-11-2007
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 5/2007
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-007-0379-4

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Springer Medicine

Three synchronized neoplasms of the female genital tract: an extraordinary presentation

Abstract

Introduction

Case

Discussion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Introduction

Case

Discussion

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