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Open Access 01-11-2017 | Review

Digestive system in psoriasis: an update

Authors: Daniel Pietrzak, Aldona Pietrzak, Dorota Krasowska, Andrzej Borzęcki, Kinga Franciszkiewicz-Pietrzak, Beata Polkowska-Pruszyńska, Maja Baranowska, Kristian Reich

Published in: Archives of Dermatological Research | Issue 9/2017

Abstract

Psoriasis is a chronic inflammatory immune-mediated disorder associated and often coexisting with many other immune-related clinical conditions including those affecting the gastrointestinal tract. Data obtained from the reviewed literature suggest an association between psoriasis and pathologies of the oral cavity, both psoriasis-specific lesions, as well as non-specific, such as geographic tongue or fissured tongue. These findings show the importance of thorough examination of oral mucosa in psoriatic patients. Inflammatory bowel diseases (IBD) are also linked with psoriasis. Crohn’s disease and ulcerative colitis share a common genetic background, inflammatory pathways and have an evident iatrogenic anti-TNF treatment link, necessitating dermatological or gastroenterological care in patients with IBD or psoriasis, respectively, as well as treatment adjusted to manifestations. The presence of celiac disease-specific antibodies in psoriatic patients and their correlation with the severity of the disease show the association between these disorders. The linking pathogenesis comprises vitamin D deficiency, immune pathway, genetic background and increase in the intestinal permeability, which suggests a potential benefit from gluten-free diet among psoriatic patients. The link between psoriasis and non-alcoholic fatty liver disease implies screening patients for components of metabolic syndrome and lifestyle changes necessity. Some studies indicate increased prevalence of cancer in patients with psoriasis, probably due to negative influence of skin lesion impact on lifestyle rather than the role of psoriasis in carcinogenesis. However, there are no sufficient data to exclude such an oncogenic hit, which is yet to be confirmed. Therefore, all psoriasis-associated comorbidities establish the importance of a multidisciplinary approach in the treatment of these patients.

Abedini R, Salehi M, Lajevardi V, Beygi S (2015) Patients with psoriasis are at a higher risk of developing nonalcoholic fatty liver disease. Clin Exp Dermatol 40(7):722–727. doi:10.1111/ced.12672 (Epub 2015 May 11) PubMedCrossRef

Abenavoli L, Leggio L, Ferrulli A, Vonghia L, Gasbarrini G, Addolorato G (2005) Association between psoriasis and coeliac disease. Br J Dermatol 152(6):1393–1394. doi:10.1111/j.1365-2133.2005.06636.x PubMedCrossRef

Abenavoli L, Proietti I, Zaccone V, Gasbarrini G, Addolorato G (2009) Celiac disease: from gluten to skin. Expert Rev Clin Immunol 5(6):789–800. doi:10.1586/eci.09.46 PubMedCrossRef

Addolorato G, Parente A, de Lorenzi G, D’Angelo Di Paola ME, Abenavoli L, Leggio L, Capristo E, De Simone C, Rotoli M, Rapaccini GL, Gasbarrini G (2003) Rapid regression of psoriasis in a coeliac patient after gluten-free diet. A case report and review of the literature. Digestion 68(1):9–12. doi:10.1159/000073220 PubMedCrossRef

Alikhani M, Khalighinejad N, Ghalaiani P, Khaleghi MA, Askari E, Gorsky M (2014) Immunologic and psychologic parameters associated with geographic tongue. Oral Surg Oral Med Oral Pathol Oral Radiol 118(1):68–71. doi:10.1016/j.oooo.2014.03.007 PubMedCrossRef

Anstee QM, Targher G, Day CP (2013) Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis. Nat Rev Gastroenterol Hepatol 10(6):330–344. doi:10.1038/nrgastro.2013.41 PubMedCrossRef

Asarch A, Barak O, Loo DS, Gottlieb AB (2008) Th17 cells: a new paradigm for cutaneous inflammation. J Dermatol Treat 19(5):259–266. doi:10.1080/09546630802206686 CrossRef

Asarch A, Barak O, Loo DS, Gottlieb AB (2008) Th17 cells: a new therapeutic target in inflammatory dermatoses. J Dermatol Treat 19(6):318–326. doi:10.1080/09546630802206660 CrossRef

Aslanian FM, Lisboa FF, Iwamoto A, Carneiro SC (2005) Clinical and epidemiological evaluation of psoriasis: clinical variants and articular manifestations. J Eur Acad Dermatol Venereol 19(1):141–142. doi:10.1111/j.1468-3083.2004.01102.x PubMedCrossRef

10.

Assimakopoulos D, Patrikakos G, Fotika C, Elisaf M (2002) Benign migratory glossitis or geographic tongue: an enigmatic oral lesion. Am J Med 113(9):751–755. doi:10.1016/S0002-9343(02)01379-7 PubMedCrossRef

11.

Atkin PA, Xu X, Thornhill MH (2002) Minor recurrent aphthous stomatitis and smoking: an epidemiological study measuring plasma cotinine. Oral Dis 8(3):173–176. doi:10.1034/j.1601-0825.2002.01826.x PubMedCrossRef

12.

Baeten D, Kruithof E, Van den Bosch F, Van den Bossche N, Herssens A, Mielants H, De Keyser F, Veys EM (2003) Systematic safety follow up in a cohort of 107 patients with spondyloarthropathy treated with infliximab: a new perspective on the role of host defence in the pathogenesis of the disease? Ann Rheum Dis 62(9):829–834. doi:10.1136/ard.62.9.829 PubMedPubMedCentralCrossRef

13.

Bernstein CN, Wajda A, Blanchard JF (2005) The clustering of other chronic inflammatory diseases in inflammatory bowel disease: a population-based study. Gastroenterology 129(3):827–836. doi:10.1053/j.gastro.2005.06.021 PubMedCrossRef

14.

Birkenfeld S, Dreiher J, Weitzman D, Cohen AD (2009) Coeliac disease associated with psoriasis. Br J Dermatol 161(6):1331–1334. doi:10.1111/j.1365-2133.2009.09398.x PubMedCrossRef

15.

Bodé S, Hassager C, Gudmand-Høyer E, Christiansen C (1991) Body composition and calcium metabolism in adult treated coeliac disease. Gut 32(11):1342–1345. doi:10.1136/gut.32.11.134 PubMedPubMedCentralCrossRef

16.

Bovenschen HJ, van Vlijmen-Willems IM, van de Kerkhof PC, van Erp PE (2006) Identification of lesional CD4+ CD25+ Foxp3+ regulatory T cells in Psoriasis. Dermatology 213(2):111–117. doi:10.1159/000093849 PubMedCrossRef

17.

Brauchli YB, Jick SS, Miret M, Meier CR (2009) Psoriasis and risk of incident cancer: an inception cohort study with a nested case-control analysis. J Invest Dermatol 129(11):2604–2612. doi:10.1038/jid.2009.113 PubMedCrossRef

18.

Bruce AJ, Rogers RS (2003) Oral psoriasis. Dermatol Clin 21(1):99–104. doi:10.1016/S0733-8635(02)00065-7 PubMedCrossRef

19.

Byrne CD, Targher G (2014) Ectopic fat, insulin resistance, and nonalcoholic fatty liver disease: implications for cardiovascular disease. Arterioscler Thromb Vasc Biol 34(6):1155–1161. doi:10.1161/ATVBAHA.114.303034 PubMedCrossRef

20.

Byrne CD, Targher G (2015) NAFLD: a multisystem disease. J Hepatol 62(1 Suppl):47–64. doi:10.1016/j.jhep.2014.12.012 CrossRef

21.

Capon F, Di Meglio P, Szaub J, Prescott NJ, Dunster C, Baumber L, Timms K, Gutin A, Abkevic V, Burden AD, Lanchbury J, Barker JN, Trembath RC, Nestle FO (2007) Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Hum Genet 122(2):201–206. doi:10.1007/s00439-007-0397-0 PubMedCrossRef

22.

Capon F, Munro M, Barker J, Trembath R (2002) Searching for the major histocompatibility complex psoriasis susceptibility gene. J Invest Dermatol 118(5):745–751. doi:10.1046/j.1523-1747.2002.01749.x PubMedCrossRef

23.

Cardinali C, Degl’innocenti D, Caproni M, Fabbri P (2002) Is the search for serum antibodies to gliadin, endomysium and tissue transglutaminase meaningful in psoriatic patients? Relationship between the pathogenesis of psoriasis and coeliac disease. Br J Dermatol 147(1):187–188PubMedCrossRef

24.

Casper U, Seiffert K, Dippel E, Zouboulis CC (1998) Exfoliatio areata linguae et mucosae oris: a mucous membrane manifestation of psoriasis pustulosa? Hautarzt 49(11):850–854. doi:10.1007/s001050050837 PubMedCrossRef

25.

Chalmers RJ, Kirby B (2000) Gluten and psoriasis. Br J Dermatol 142(1):5–7. doi:10.1046/j.1365-2133.2000.03345.x PubMedCrossRef

26.

Chandran V, Raychaudhuri SP (2010) Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis. J Autoimmun 34(3):24. doi:10.1016/j.jaut.2009.12.001 CrossRef

27.

Chen YJ, Wu CY, Chen TJ, Shen JL, Chu SY, Wang CB, Chang YT (2011) The risk of cancer in patients with psoriasis: a population-based cohort study in Taiwan. J Am Acad Dermatol 65(1):84–91. doi:10.1016/j.jaad.2010.04.046 PubMedCrossRef

28.

Cho JH, Nicolae DL, Gold LH, Fields CT, LaBuda MC, Rohal PM, Pickles MR, Qin L, Fu Y, Mann JS, Kirschner BS, Jabs EW, Weber J, Hanauer SB, Bayless TM, Brant SR (1998) Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. Proc Natl Acad Sci USA 95(13):7502–7507. doi:10.1073/pnas.95.13.7502 PubMedPubMedCentralCrossRef

29.

Cianci R, Cammarota G, Frisullo G, Pagliari D, Ianiro G, Martini M, Frosali S, Plantone D, Damato V, Casciano F, Landolfi R, Paola Batocchi A, Pandolfi F (2012) Tissue-infiltrating lymphocytes analysis reveals large modifications of the duodenal “immunological niche” in coeliac disease after gluten-free diet. Clin Transl Gastroenterol 3:e28. doi:10.1038/ctg.2012.22 PubMedPubMedCentralCrossRef

30.

Cohen AD, Dreiher J, Birkenfeld S (2009) Psoriasis associated with ulcerative colitis and Crohn’s disease. J Eur Acad Dermatol Venereol 23(5):561–565. doi:10.1111/j.1468-3083.2008.03031.x PubMedCrossRef

31.

Collamer AN, Battafarano DF (2010) Psoriatic skin lesions induced by tumor necrosis factor antagonist therapy: clinical features and possible immunopathogenesis. Semin Arthritis Rheum 40(3):233–240. doi:10.1016/j.semarthrit.2010.04.003 PubMedCrossRef

32.

Collamer AN, Guerrero KT, Henning JS, Battafarano DF (2008) Psoriatic skin lesions induced by tumor necrosis factor antagonist therapy: a literature review and potential mechanisms of action. Arthritis Rheum 59(7):996–1001. doi:10.1002/art.23835 PubMedCrossRef

33.

Collin P, Reunala T (2003) Recognition and management of the cutaneous manifestations of celiac disease: a guide for dermatologists. Am J Clin Dermatol 4(1):13–20. doi:10.2165/00128071-200304010-00002 PubMedCrossRef

34.

Costa SC, Hirota SK, Takahashi MD, Andrade H Jr, Migliari DA (2009) Oral lesions in 166 patients with cutaneous psoriasis: a controlled study. Med Oral Patol Oral Cir Bucal 14(8):e371–e375PubMed

35.

Cullen G, Kroshinsky D, Cheifetz AS, Korzenik JR (2011) Psoriasis associated with anti-tumour necrosis factor therapy in inflammatory bowel disease: a new series and a review of 120 cases from the literature. Aliment Pharmacol Ther 34(11–12):1318–1327. doi:10.1111/j.1365-2036.2011.04866.x PubMedCrossRef

36.

Damasiewicz-Bodzek A, Wielkoszynski T (2008) Serologic markers of celiac disease in psoriatic patients. J Eur Acad Dermatol Venereol 22(9):1055–1061. doi:10.1111/j.1468-3083.2008.02713.x PubMedCrossRef

37.

Daneshpazhooh M, Moslehi H, Akhyani M, Etesami M (2004) Tongue lesions in psoriasis: a controlled study. BMC Dermatol 4(1):16. doi:10.1186/1471-5945-4-16 PubMedPubMedCentralCrossRef

38.

Darwazeh AM, Pillai K (1993) Prevalence of tongue lesions in 1013 Jordanian dental outpatients. Community Dent Oral Epidemiol 21(5):323–324. doi:10.1111/j.1600-0528.1993.tb00785.x PubMedCrossRef

39.

De Boer WA, Tytgat GN (1992) A patient with osteomalacia as single presenting symptom of gluten-sensitive enteropathy. J Intern Med 232(1):81–85. doi:10.1111/j.1365-2796.1992.tb00554.x PubMedCrossRef

40.

de Gannes GC, Ghoreishi M, Pope J, Russell A, Bell D, Adams S, Shojania K, Martinka M, Dutz JP (2007) Psoriasis and pustular dermatitis triggered by TNF-{alpha} inhibitors in patients with rheumatologic conditions. Arch Dermatol 143(2):223–231. doi:10.1001/archderm.143.2.223 PubMedCrossRef

41.

D’Erme AM, Agnoletti AF, Prignano F (2013) Fissured tongue responding to biologics during the treatment of psoriasis: the importance of detecting oral involvement of psoriasis. Dermatol Ther 26(4):364–366. doi:10.1111/dth.12000 PubMedCrossRef

42.

Di Cesare A, Di Meglio P, Nestle FO (2009) The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol 129(6):1339–1350. doi:10.1038/jid.2009.59 PubMedCrossRef

43.

dos Santos PJ, Bessa CF, de Aguiar MC, do Carmo MA (2004) Cross-sectional study of oral mucosal conditions among a central Amazonian Indian community, Brazil. J Oral Pathol Med 33(1):7–12. doi:10.1111/j.1600-0714.2004.00003.x PubMedCrossRef

44.

Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH (2006) A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314(5804):1461–1463. doi:10.1126/science.1135245 PubMedPubMedCentralCrossRef

45.

Enlund F, Samuelsson L, Enerbäck C, Inerot A, Wahlström J, Yhr M, Torinsson A, Riley J, Swanbeck G, Martinsson T (1999) Psoriasis susceptibility locus in chromosome region 3q21 identified in patients from southwest Sweden. Eur J Hum Genet 7(7):783–790. doi:10.1038/sj.ejhg.5200365 PubMedCrossRef

46.

Farrell GC (2002) Drugs and steatohepatitis. Semin Liver Dis 22(2):185–194. doi:10.1055/s-2002-30106 PubMedCrossRef

47.

Fatahzadeh M, Schwartz RA (2016) Oral psoriasis: an overlooked enigma. Dermatology 232(3):319–325. doi:10.1159/000444850 PubMedCrossRef

48.

Femiano F (2001) Geographic tongue (migrant glossitis) and psoriasis. Minerva Stomatol 50(6):213–217PubMed

49.

Ferrandiz C, Pujol RM, Garcia-Patos V, Bordas X, Smandia JA (2002) Psoriasis of early and late onset: a clinical and epidemiologic study from Spain. J Am Acad Dermatol 46(6):867–873. doi:10.1067/mjd.2002.120470 PubMedCrossRef

50.

Fitch E, Harper E, Skorcheva I, Kurtz SE, Blauvelt A (2007) Pathophysiology of psoriasis: recent advances on IL-23 and Th17 cytokines. Curr Rheumatol Rep 9(6):461–467. doi:10.1007/s11926-007-0075-1 PubMedPubMedCentralCrossRef

51.

Fitzpatrick LR (2013) Inhibition of IL-17 as a pharmacological approach for IBD. Int Rev Immunol 32:544–555. doi:10.3109/08830185.2013.821118 PubMedCrossRef

52.

Frentz G, Olsen JH (1999) Malignant tumours and psoriasis: a follow-up study. Br J Dermatol 140(2):237–242. doi:10.1046/j.1365-2133.1999.02655.x PubMedCrossRef

53.

Frikha F, Snoussi M, Bahloul Z (2012) Osteomalacia associated with cutaneous psoriasis as the presenting feature of coeliac disease: a case report. Pan Afr Med J 11:58. doi:10.11604/pamj.2012.11.58.1613 PubMedPubMedCentral

54.

Funk J, Langeland T, Schrumpf E, Hanssen LE (1991) Psoriasis induced by interferon-alpha. Br J Dermatol 125(5):463–465. doi:10.1111/j.1365-2133.1991.tb14774.x PubMedCrossRef

55.

Ganzetti G, Campanati A, Santarelli A, Pozzi V, Molinelli E, Minnetti I, Brisigotti V, Procaccini M, Emanuelli M, Offidani A (2015) Involvement of the oral cavity in psoriasis: results of a clinical study. Br J Dermatol 172(1):282–285. doi:10.1111/bjd.13201 PubMedCrossRef

56.

Gilliet M, Conrad C, Geiges M, Cozzio A, Thürlimann W, Burg G, Nestle FO, Dummer R (2004) Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors. Arch Dermatol 140(12):1490–1495. doi:10.1001/archderm.140.12.1490 PubMedCrossRef

57.

Gisondi P, Cazzaniga S, Chimenti S, Giannetti A, Maccarone M, Picardo M, Girolomoni G, Naldi L, Psocare Study Group (2013) Metabolic abnormalities associated with initiation of systemic treatment for psoriasis: evidence from the Italian Psocare Registry. J Eur Acad Dermatol Venereol 27(1):1468–3083. doi:10.1111/j.1468-3083.2012.04450.x CrossRef

58.

Gisondi P, Del Giglio M, Cozzi A, Girolomoni G (2010) Psoriasis, the liver, and the gastrointestinal tract. Dermatol Ther 23(2):155–159. doi:10.1111/j.1529-8019.2010.01310.x PubMedCrossRef

59.

Gisondi P, Galvan A, Idolazzi L, Girolomoni G (2015) Management of moderate to severe psoriasis in patients with metabolic comorbidities. Front Med (Lausanne) 2:1. doi:10.3389/fmed.2015.00001

60.

Gisondi P, Targher G, Zoppini G, Girolomoni G (2009) Non-alcoholic fatty liver disease in patients with chronic plaque psoriasis. J Hepatol 51(4):758–764. doi:10.1016/j.jhep.2009.04.020 PubMedCrossRef

61.

Gonzaga HF, Chaves MD, Gonzaga LH, Picciani BL, Jorge MA, Dias EP, Tomimori J (2015) Environmental factors in benign migratory glossitis and psoriasis: retrospective study of the association of emotional stress and alcohol and tobacco consumption with benign migratory glossitis and cutaneous psoriasis. J Eur Acad Dermatol Venereol 29(3):533–536. doi:10.1111/jdv.12616 PubMedCrossRef

62.

Gonzaga HF, Marcos EV, Santana FC, Jorge MA, Tomimori J (2013) HLA alleles in Brazilian patients with fissured tongue. J Eur Acad Dermatol Venereol 27(2):1468–3083. doi:10.1111/j.1468-3083.2012.04537.x CrossRef

63.

Gonzaga HF, Torres EA, Alchorne MM, Gerbase-Delima M (1996) Both psoriasis and benign migratory glossitis are associated with HLA-Cw6. Br J Dermatol 135(3):368–370. doi:10.1046/j.1365-2133.1996.d01-1006.x PubMedCrossRef

64.

Goswami M, Verma A, Verma M (2012) Benign migratory glossitis with fissured tongue. J Indian Soc Pedod Prev Dent 30(2):173–175. doi:10.4103/0970-4388.100008 PubMedCrossRef

65.

Gottlieb AB, Chao C, Dann F (2008) Psoriasis comorbidities. J Dermatol Treat 19(1):5–21. doi:10.1080/09546630701364768 CrossRef

66.

Gottlieb AB, Evans R, Li S, Dooley LT, Guzzo CA, Baker D, Bala M, Marano CW, Menter A (2004) Infliximab induction therapy for patients with severe plaque-type psoriasis: a randomized, double-blind, placebo-controlled trial. J Am Acad Dermatol 51(4):534–542. doi:10.1016/j.jaad.2004.02.021 PubMedCrossRef

67.

Guerra I, Algaba A, Pérez-Calle JL, Chaparro M, Marín-Jiménez I, García-Castellanos R, González-Lama Y, López-Sanromán A, Manceñido N, Martínez-Montiel P, Quintanilla E, Taxonera C, Villafruela M, Romero-Maté A, López-Serrano P, Gisbert JP, Bermejo F (2012) Induction of psoriasis with anti-TNF agents in patients with inflammatory bowel disease: a report of 21 cases. J Crohns Colitis 6(5):518–523. doi:10.1016/j.crohns.2011.10.007 PubMedCrossRef

68.

Guimaraes AL, Correia-Silva Jde F, Diniz MG, Xavier GM, Horta MC, Gomez RS (2007) Investigation of functional gene polymorphisms: IL-1B, IL-6 and TNFA in benign migratory glossitis in Brazilian individuals. J Oral Pathol Med 36(9):533–537. doi:10.1111/j.1600-0714.2007.00559.x PubMedCrossRef

69.

Hafström I, Ringertz B, Spångberg A, von Zweigbergk L, Brannemark S, Nylander I, Rönnelid J, Laasonen L, Klareskog L (2001) A vegan diet free of gluten improves the signs and symptoms of rheumatoid arthritis: the effects on arthritis correlate with a reduction in antibodies to food antigens. Rheumatology 40(10):1175–1179. doi:10.1093/rheumatology/40.10.1175 PubMedCrossRef

70.

Hammer B, Ashurst P, Naish J (1968) Diseases associated with ulcerative colitis and Crohn’s disease. Gut 9(1):17–21PubMedPubMedCentralCrossRef

71.

Hannuksela-Svahn A, Pukkala E, Laara E, Poikolainen K, Karvonen J (2000) Psoriasis, its treatment, and cancer in a cohort of Finnish patients. J Invest Dermatol 114(3):587–590. doi:10.1046/j.1523-1747.2000.00898.x PubMedCrossRef

72.

Hardwick RN, Clarke JD, Lake AD, Canet MJ, Anumol T, Street SM, Merrell MD, Goedken MJ, Snyder SA, Cherrington NJ (2014) Increased susceptibility to methotrexate-induced toxicity in nonalcoholic steatohepatitis. Toxicol Sci 142(1):45–55. doi:10.1093/toxsci/kfu156 PubMedPubMedCentralCrossRef

73.

Harrison MJ, Dixon WG, Watson KD, King Y, Groves R, Hyrich KL, Symmons DP, British Society for Rheumatology Biologics Register Control Centre Consortium, BSRBR (2009) Rates of new-onset psoriasis in patients with rheumatoid arthritis receiving anti-tumour necrosis factor alpha therapy: results from the British Society for Rheumatology Biologics Register. Ann Rheum Dis 68(2):209–215. doi:10.1136/ard.2007.087288 PubMedCrossRef

74.

Henseler T, Christophers E (1985) Psoriasis of early and late onset: characterization of two types of psoriasis vulgaris. J Am Acad Dermatol 13(3):450–456. doi:10.1016/S0190-9622(85)70188-0 PubMedCrossRef

75.

Hernández-Pérez F, Jaimes-Aveldañez A, Urquizo-Ruvalcaba Mde L, Díaz-Barcelot M, Irigoyen-Camacho ME, Vega-Memije ME, Mosqueda-Taylor A (2008) Prevalence of oral lesions in patients with psoriasis. Med Oral Patol Oral Cir Bucal 13(11):E703–E708PubMed

76.

Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS (2006) The majority of human peripheral blood CD4+ CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. J Immunol 177(7):4488–4494. doi:10.4049/jimmunol.177.7.4488 PubMedCrossRef

77.

Honarmand M, Farhad Mollashahi L, Shirzaiy M, Sehhatpour M (2013) Geographic tongue and associated risk factors among iranian dental patients. Iran J Public Health 42(2):215–219PubMedPubMedCentral

78.

Hugot JP, Chamaillard M, Zouali H, Lesage S, Cézard JP, Belaiche J, Almer S, Tysk C, O’Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature 411(6837):599–603. doi:10.1038/35079107 PubMedCrossRef

79.

Hugot JP, Laurent-Puig P, Gower-Rousseau C, Olson JM, Lee JC, Beaugerie L, Naom I, Dupas JL, Van Gossum A, Orholm M, Bonaiti-Pellie C, Weissenbach J, Mathew CG, Lennard-Jones JE, Cortot A, Colombel JF, Thomas G (1996) Mapping of a susceptibility locus for Crohn’s disease on chromosome 16. Nature 379(6568):821–823. doi:10.1038/379821a0 PubMedCrossRef

80.

Humbert P, Bidet A, Treffel P, Drobacheff C, Agache P (1991) Intestinal permeability in patients with psoriasis. J Dermatol Sci 2(4):324–326PubMedCrossRef

81.

Hunter CA, Jones SA (2015) IL-6 as a keystone cytokine in health and disease. Nat Immunol 16(5):448–457. doi:10.1038/ni.3153 PubMedCrossRef

82.

Iborra M, Beltran B, Bastida G, Aguas M, Nos P (2011) Infliximab and adalimumab-induced psoriasis in Crohn’s disease: a paradoxical side effect. J Crohns Colitis 5(2):157–161. doi:10.1016/j.crohns.2010.11.001 PubMedCrossRef

83.

Iltanen S, Collin P, Korpela M, Holm K, Partanen J, Polvi A, Mäki M (1999) Celiac disease and markers of celiac disease latency in patients with primary Sjogren’s syndrome. Am J Gastroenterol 94(4):1042–1046. doi:10.1111/j.1572-0241.1999.01011.x PubMed

84.

Ishibashi M, Tojo G, Watanabe M, Tamabuchi T, Masu T, Aiba S (2010) Geographic tongue treated with topical tacrolimus. J Dermatol Case Rep 4(4):57–59. doi:10.3315/jdcr.2010.1058 PubMedPubMedCentral

85.

Jainkittivong A, Langlais RP (2005) Geographic tongue: clinical characteristics of 188 cases. J Contemp Dent Pract 6(1):123–135PubMed

86.

Ji J, Shu X, Sundquist K, Sundquist J, Hemminki K (2009) Cancer risk in hospitalized psoriasis patients: a follow-up study in Sweden. Br J Cancer 100(9):1499–1502. doi:10.1038/sj.bjc.6605027 PubMedPubMedCentralCrossRef

87.

Juzlova K, Votrubova J, Dzambova M, Gopfertova D, Hercogova J, Smerhovsky Z (2016) Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: the results of 189 patients with psoriasis and 378 controls. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 160(1):100–105. doi:10.5507/bp.2015.048 PubMed

88.

Kalb RE, Strober B, Weinstein G, Lebwohl M (2009) Methotrexate and psoriasis: 2009 national psoriasis foundation consensus conference. J Am Acad Dermatol 60(5):824–837. doi:10.1016/j.jaad.2008.11.906 PubMedCrossRef

89.

Kia KF, Nair RP, Ike RW, Hiremagalore R, Elder JT, Ellis CN (2007) Prevalence of antigliadin antibodies in patients with psoriasis is not elevated compared with controls. Am J Clin Dermatol 8(5):301–305. doi:10.2165/00128071-200708050-00005 PubMedCrossRef

90.

Ko JM, Gottlieb AB, Kerbleski JF (2009) Induction and exacerbation of psoriasis with TNF-blockade therapy: a review and analysis of 127 cases. J Dermatol Treat 20(2):100–108. doi:10.1080/09546630802441234 CrossRef

91.

Kupfer SS, Jabri B (2012) Pathophysiology of celiac disease. Gastrointest Endosc Clin N Am 22(4):639–660. doi:10.1016/j.giec.2012.07.003 PubMedCrossRef

92.

Kupper C (2005) Dietary guidelines and implementation for celiac disease. Gastroenterology 128(4 Suppl 1):121–127. doi:10.1053/j.gastro.2005.02.024 CrossRef

93.

Ladoyanni E, Nambi R (2005) Psoriasis exacerbated by interferon-alpha in a patient with chronic myeloid leukemia. J Drugs Dermatol 4(2):221–222PubMed

94.

Lannan S, McLean A, Drost E, Gillooly M, Donaldson K, Lamb D, MacNee W (1992) Changes in neutrophil morphology and morphometry following exposure to cigarette smoke. Int J Exp Pathol 73(2):183–191PubMedPubMedCentral

95.

Lee E, Trepicchio WL, Oestreicher JL, Pittman D, Wang F, Chamian F, Dhodapkar M, Krueger JG (2004) Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med 199(1):125–130. doi:10.1084/jem.20030451 PubMedPubMedCentralCrossRef

96.

Lee FI, Bellary SV, Francis C (1990) Increased occurrence of psoriasis in patients with Crohn’s disease and their relatives. Am J Gastroenterol 85(8):962–963. doi:10.1111/j.1572-0241.1990.tb06788.x PubMed

97.

Lee HH, Song IH, Friedrich M, Gauliard A, Detert J, Röwert J, Audring H, Kary S, Burmester GR, Sterry W, Worm M (2007) Cutaneous side-effects in patients with rheumatic diseases during application of tumour necrosis factor-alpha antagonists. Br J Dermatol 156(3):486–491. doi:10.1111/j.1365-2133.2007.07682.x PubMedCrossRef

98.

Lehmann B (2009) Role of the vitamin D3 pathway in healthy and diseased skin—facts, contradictions and hypotheses. Exp Dermatol 18(2):97–108. doi:10.1111/j.1600-0625.2008.00810.x PubMedCrossRef

99.

León AJ, Garrote JA, Blanco-Quirós A, Calvo C, Fernández-Salazar L, Del Villar A, Barrera A, Arranz E (2006) Interleukin 18 maintains a long-standing inflammation in coeliac disease patients. Clin Exp Immunol 146(3):479–485. doi:10.1111/j.1365-2249.2006.03239.x PubMedPubMedCentralCrossRef

100.

Li WQ, Han JL, Chan AT, Qureshi AA (2013) Psoriasis, psoriatic arthritis and increased risk of incident Crohn’s disease in US women. Ann Rheum Dis 72(7):1200–1205. doi:10.1136/annrheumdis-2012-202143 PubMedCrossRef

101.

Lima Ede A, Lima Mde A (2011) Reviewing concepts in the immunopathogenesis of psoriasis. An Bras Dermatol 86(6):1151–1158. doi:10.1590/S0365-05962011000600014 PubMedCrossRef

102.

Lindqvist U, Rudsander A, Boström A, Nilsson B, Michaëlsson G (2002) IgA antibodies to gliadin and coeliac disease in psoriatic arthritis. Rheumatology 41(1):31–37. doi:10.1093/rheumatology/41.1.31 PubMedCrossRef

103.

Loria P, Carulli L, Bertolotti M, Lonardo A (2009) Endocrine and liver interaction: the role of endocrine pathways in NASH. Nat Rev Gastroenterol Hepatol 6(4):236–247. doi:10.1038/nrgastro.2009.33 PubMedCrossRef

104.

Loria P, Lonardo A, Bellentani S, Day CP, Marchesini G, Carulli N (2007) Non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease: an open question. Nutr Metab Cardiovasc Dis 17(9):684–698. doi:10.1016/j.numecd.2007.01.007 PubMedCrossRef

105.

Lu Y, Chen H, Nikamo P, Qi Low H, Helms C, Seielstad M, Liu J, Bowcock AM, Stahle M, Liao W (2013) Association of cardiovascular and metabolic disease genes with psoriasis. J Invest Dermatol 133(3):836–839. doi:10.1038/jid.2012.366 PubMedCrossRef

106.

Ludvigsson JF, Lindelof B, Zingone F, Ciacci C (2011) Psoriasis in a nationwide cohort study of patients with celiac disease. J Invest Dermatol 131(10):2010–2016. doi:10.1038/jid.2011.162 PubMedCrossRef

107.

Mantovani A, Gisondi P, Lonardo A, Targher G (2016) Relationship between non-alcoholic fatty liver disease and psoriasis: a novel hepato-dermal axis? Int J Mol Sci. doi:10.3390/ijms17020217 PubMedPubMedCentral

108.

Margolis D, Bilker W, Hennessy S, Vittorio C, Santanna J, Strom BL (2001) The risk of malignancy associated with psoriasis. Arch Dermatol 137(6):778–783PubMed

109.

Matthews D, Fry L, Powles A, Weber J, McCarthy M, Fisher E, Davies K, Williamson R (1996) Evidence that a locus for familial psoriasis maps to chromosome 4q. Nat Genet 14(2):231–233. doi:10.1038/ng1096-231 PubMedCrossRef

110.

Mattsson U, Warfvinge G, Jontell M (2015) Oral psoriasis-a diagnostic dilemma: a report of two cases and a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol 120(4):e183–e189. doi:10.1016/j.oooo.2015.03.005 PubMedCrossRef

111.

Menter A, Tyring SK, Gordon K, Kimball AB, Leonardi CL, Langley RG, Strober BE, Kaul M, Gu Y, Okun M, Papp K (2008) Adalimumab therapy for moderate to severe psoriasis: a randomized, controlled phase III trial. J Am Acad Dermatol 58(1):106–115. doi:10.1016/j.jaad.2007.09.010 PubMedCrossRef

112.

Michaelsson G, Ahs S, Hammarstrom I, Lundin IP, Hagforsen E (2003) Gluten-free diet in psoriasis patients with antibodies to gliadin results in decreased expression of tissue transglutaminase and fewer Ki67+ cells in the dermis. Acta Derm Venereol 83(6):425–429. doi:10.1080/00015550310015022 PubMedCrossRef

113.

Michaelsson G, Gerden B, Hagforsen E, Nilsson B, Pihl-Lundin I, Kraaz W et al (2000) Psoriasis patients with antibodies to gliadin can be improved by a gluten-free diet. Br J Dermatol 142(1):44–51. doi:10.1046/j.1365-2133.2000.03240.x PubMedCrossRef

114.

Michaelsson G, Kajermo U, Michaelsson A, Hagforsen E (2005) Infliximab can precipitate as well as worsen palmoplantar pustulosis: possible linkage to the expression of tumour necrosis factor-alpha in the normal palmar eccrine sweat duct? Br J Dermatol 153(6):1243–1244. doi:10.1111/j.1365-2133.2005.06977.x PubMedCrossRef

115.

Miele L, Vallone S, Cefalo C, La Torre G, Di Stasi C, Vecchio FM, D’Agostino M, Gabrieli ML, Vero V, Biolato M, Pompili M, Gasbarrini G, Rapaccini G, Amerio P, De Simone C, Grieco A (2009) Prevalence, characteristics and severity of non-alcoholic fatty liver disease in patients with chronic plaque psoriasis. J Hepatol 51(4):778–786. doi:10.1016/j.jhep.2009.06.008 PubMedCrossRef

116.

Migliari DA, Penha SS, Marques MM, Matthews RW (2004) Considerations on the diagnosis of oral psoriasis: a case report. Med Oral 9(4):300–303PubMed

117.

Miloğlu O, Göregen M, Akgül HM, Acemoğlu H (2009) The prevalence and risk factors associated with benign migratory glossitis lesions in 7619 Turkish dental outpatients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107(2):29–33. doi:10.1016/j.tripleo.2008.10.015 CrossRef

118.

Montesu MA, Dessi-Fulgheri C, Pattaro C, Ventura V, Satta R, Cottoni F (2011) Association between psoriasis and coeliac disease? A case-control study. Acta Derm Venereol 91(1):92–93. doi:10.2340/00015555-0960 PubMedCrossRef

119.

Nair RP, Henseler T, Jenisch S, Stuart P, Bichakjian CK, Lenk W, Westphal E, Guo SW, Christophers E, Voorhees JJ, Elder JT (1997) Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan. Hum Mol Genet 6(8):1349–1356. doi:10.1093/hmg/6.8.1349 PubMedCrossRef

120.

Nestle FO, Conrad C, Tun-Kyi A, Homey B, Gombert M, Boyman O et al (2005) Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J Exp Med 202(1):135–143. doi:10.1084/jem.20050500 PubMedPubMedCentralCrossRef

121.

Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nuñez G, Cho JH (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature 411(6837):603–606. doi:10.1038/35079114 PubMedCrossRef

122.

Ojetti V, Aguilar Sanchez J, Guerriero C, Fossati B, Capizzi R, De Simone C, Migneco A, Amerio P, Gasbarrini G, Gasbarrini A (2003) High prevalence of celiac disease in psoriasis. Am J Gastroenterol 98(11):2574–2575. doi:10.1111/j.1572-0241.2003.08684.x PubMedCrossRef

123.

Paimela L, Kurki P, Leirisalo-Repo M, Piirainen H (1995) Gliadin immune reactivity in patients with rheumatoid arthritis. Clin Exp Rheumatol 13(5):603–607PubMed

124.

Palucka AK, Blanck JP, Bennett L, Pascual V, Banchereau J (2005) Cross-regulation of TNF and IFN-alpha in autoimmune diseases. Proc Natl Acad Sci USA 102(9):3372–3377. doi:10.1073/pnas.0408506102 PubMedPubMedCentralCrossRef

125.

Parisi R, Symmons DP, Griffiths CE, Ashcroft DM (2013) Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol 133(2):377–385. doi:10.1038/jid.2012.339 PubMedCrossRef

126.

Paul CF, Ho VC, McGeown C, Christophers E, Schmidtmann B, Guillaume JC, Lamarque V, Dubertret L (2003) Risk of malignancies in psoriasis patients treated with cyclosporine: a 5 y cohort study. J Invest Dermatol 120(2):211–216. doi:10.1046/j.1523-1747.2003.12040.x PubMedCrossRef

127.

Picciani B, Silva-Junior G, Carneiro S, Sampaio AL, Goldemberg DC, Oliveira J, Porto LC, Dias EP (2012) Geographic stomatitis: an oral manifestation of psoriasis? J Dermatol Case Rep 6(4):113–116. doi:10.3315/jdcr.2012.1118 PubMedPubMedCentralCrossRef

128.

Picciani BL, Domingos TA, Teixeira-Souza T, Santos Vde C, Gonzaga HF, Cardoso-Oliveira J, Gripp AC, Dias EP, Carneiro S (2016) Geographic tongue and psoriasis: clinical, histopathological, immunohistochemical and genetic correlation—a literature review. An Bras Dermatol 91(4):410–421. doi:10.1590/abd1806-4841.20164288 PubMedPubMedCentralCrossRef

129.

Picciani BL, Silva-Junior GO, Michalski-Santos B, Avelleira JC, Azulay DR, Pires FR, Dias EP, Cantisano MH (2011) Prevalence of oral manifestations in 203 patients with psoriasis. J Eur Acad Dermatol Venereol 25(12):1481–1483. doi:10.1111/j.1468-3083.2010.03936.x PubMedCrossRef

130.

Picciani BLS, Souza TT, Santos VCB, Domingos TA, Carneiro S, Avelleira JC et al (2015) Geographic tongue and fissured tongue in 348 patients with psoriasis: correlation with disease severity. Sci World J 564326:1–7. doi:10.1155/2015/564326 CrossRef

131.

Pogrel MA, Cram D (1988) Intraoral findings in patients with psoriasis with a special reference to ectopic geographic tongue (erythema circinata). Oral Surg Oral Med Oral Pathol 66(2):184–189. doi:10.1016/0030-4220(88)90091-6 PubMedCrossRef

132.

Pouplard C, Brenaut E, Horreau C, Barnetche T, Misery L, Richard MA, Aractingi S, Aubin F, Cribier B, Joly P, Jullien D, Le Maître M, Ortonne JP, Paul C (2013) Risk of cancer in psoriasis: a systematic review and meta-analysis of epidemiological studies. J Eur Acad Dermatol Venereol 3:36–46. doi:10.1111/jdv.12165 CrossRef

133.

Prignano F, D’Erme AM, Bonciolini V, Lotti T (2011) Mucosal psoriasis: a new insight toward a systemic inflammatory disease. Int J Dermatol 50(12):1579–1581. doi:10.1111/j.1365-4632.2010.04864.x PubMedCrossRef

134.

Prizment AE, Alonso A, Folsom AR, Ahmed RL, Virnig BA, Warshaw EM, Anderson KE (2011) Association between psoriasis and incident cancer: the Iowa’s Women’s Health Study. Cancer Causes Control 22(7):1003–1010. doi:10.1007/s10552-011-9773-0 PubMedPubMedCentralCrossRef

135.

Rahier JF, Buche S, Peyrin-Biroulet L, Bouhnik Y, Duclos B, Louis E, Papay P, Allez M, Cosnes J, Cortot A, Laharie D, Reimund JM, Lémann M, Delaporte E, Colombel JF, Groupe d’Etude Thérapeutique des Affections Inflammatoires du Tube Digestif (GETAID) (2010) Severe skin lesions cause patients with inflammatory bowel disease to discontinue anti-tumor necrosis factor therapy. Clin Gastroenterol Hepatol 8(12):1048–1055. doi:10.1016/j.cgh.2010.07.022 PubMedCrossRef

136.

Rensch MJ, Szyjkowski R, Shaffer RT, Fink S, Kopecky C, Grissmer L, Enzenhauer R, Kadakia S (2001) The prevalence of celiac disease autoantibodies in patients with systemic lupus erythematosus. Am J Gastroenterol 96(4):1113–1115. doi:10.1111/j.1572-0241.2001.03753.x PubMedCrossRef

137.

Rodrigo L (2006) Celiac disease. World J Gastroenterol 12(41):6585–6593. doi:10.3748/WJG.v12.i41.6585 PubMedCrossRef

138.

Rogers RS 3rd, Bruce AJ (2004) The tongue in clinical diagnosis. J Eur Acad Dermatol Venereol 18(3):254–259. doi:10.1111/j.1468-3083.2004.00769.x PubMedCrossRef

139.

Rosenberg P, Urwitz H, Johannesson A, Ros AM, Lindholm J, Kinnman N, Hultcrantz R (2007) Psoriasis patients with diabetes type 2 are at high risk of developing liver fibrosis during methotrexate treatment. J Hepatol 46(6):1111–1118. doi:10.1016/j.jhep.2007.01.024 PubMedCrossRef

140.

Rostami K, Aldulaimi D, Holmes G, Johnson MW, Robert M, Srivastava A, Fléjou JF, Sanders DS, Volta U, Derakhshan MH, Going JJ, Becheanu G, Catassi C, Danciu M, Materacki L, Ghafarzadegan K, Ishaq S, Rostami-Nejad M, Peña AS, Bassotti G, Marsh MN, Villanacci V (2015) Microscopic enteritis: bucharest consensus. World J Gastroenterol 21(9):2593–2604. doi:10.3748/wjg.v21.i9.2593 PubMedPubMedCentralCrossRef

141.

Rostom A, Murray JA, Kagnoff MF (2006) American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease. Gastroenterology 131(6):1981–2002. doi:10.1053/j.gastro.2006.10.004 PubMedCrossRef

142.

Sabat R, Philipp S, Hoflich C, Kreutzer S, Wallace E, Asadullah K, Volk HD, Sterry W, Wolk K (2007) Immunopathogenesis of psoriasis. Exp Dermatol 16(10):779–798. doi:10.1111/j.1600-0625.2007.00629.x PubMedCrossRef

143.

Salvati VM, MacDonald TT, Bajaj-Elliott M, Borrelli M, Staiano A, Auricchio S, Troncone R, Monteleone G (2002) Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease. Gut 50(2):186–190. doi:10.1136/gut.50.2.186 PubMedPubMedCentralCrossRef

144.

Saruta M, Yu QT, Fleshner PR, Mantel PY, Schmidt-Weber CB, Banham AH, Papadakis KA (2007) Characterization of FOXP3+ CD4+ regulatory T cells in Crohn’s disease. Clin Immunol 125(3):281–290. doi:10.1016/j.clim.2007.08.003 PubMedCrossRef

145.

Satsangi J, Parkes M, Louis E, Hashimoto L, Kato N, Welsh K, Terwilliger JD, Lathrop GM, Bell JI, Jewell DP (1996) Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nat Genet 14(2):199–202. doi:10.1038/ng1096-199 PubMedCrossRef

146.

Saurat JH, Stingl G, Dubertret L, Papp K, Langley RG, Ortonne JP, Unnebrink K, Kaul M, Camez A, CHAMPION Study Investigators (2008) Efficacy and safety results from the randomized controlled comparative study of adalimumab vs. methotrexate vs. placebo in patients with psoriasis (CHAMPION). Br J Dermatol 158(3):558–566. doi:10.1111/j.1365-2133.2007.08315.x PubMedCrossRef

147.

Sfikakis PP, Iliopoulos A, Elezoglou A, Kittas C, Stratigos A (2005) Psoriasis induced by anti-tumor necrosis factor therapy: a paradoxical adverse reaction. Arthritis Rheum 52(8):2513–2518. doi:10.1002/art.21233 PubMedCrossRef

148.

Shoelson SE, Lee J, Goldfine AB (2006) Inflammation and insulin resistance. J Clin Invest 116(7):1793–1801. doi:10.1172/JCI29069 PubMedPubMedCentralCrossRef

149.

Shulman GI (2014) Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N Engl J Med 371(23):2237–2238. doi:10.1056/NEJMc1412427 PubMed

150.

Singh S, Nivash S, Mann BK (2013) Matched case-control study to examine association of psoriasis and migratory glossitis in India. Indian J Dermatol Venereol Leprol 79(1):59–64. doi:10.4103/0378-6323.104670 PubMedCrossRef

151.

Skavland J, Shewry PR, Marsh J, Geisner B, Marcusson JA (2012) In vitro screening for putative psoriasis-specific antigens among wheat proteins and peptides. Br J Dermatol 166(1):67–73. doi:10.1111/j.1365-2133.2011.10608.x PubMedCrossRef

152.

Skroza N, Skroza N, Proietti I, Pampena R (2013) Correlations between psoriasis and inflammatory bowel diseases. Biomed Res Int 2013:983902PubMedPubMedCentralCrossRef

153.

Stefan N, Haring HU (2013) The role of hepatokines in metabolism. Nat Rev Endocrinol 9(3):144–152. doi:10.1038/nrendo.2012.258 PubMedCrossRef

154.

Taccari E, Spada S, Giuliani A, Sorgi ML, Pecorella I, Onetti Muda A (2002) Co-occurrence of psoriatic arthritis with collagenous colitis: clinicopathologic findings of a case. Clin Rheumatol 21(4):335–338. doi:10.1007/s100670200088 PubMedCrossRef

155.

Targher G, Marra F, Marchesini G (2008) Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon? Diabetologia 51(11):1947–1953. doi:10.1007/s00125-008-1135-4 PubMedCrossRef

156.

Tesmer LA, Lundy SK, Sarkar S, Fox DA (2008) Th17 cells in human disease. Immunol Rev 223:87–113. doi:10.1111/j.1600-065X.2008.00628.x PubMedPubMedCentralCrossRef

157.

Tichy M, Hercogova J (2014) Manifestation of Crohn’s disease in a young woman during the course of treatment for severe form of chronic plaque psoriasis with etanercept. Dermatol Ther 27(4):211–214. doi:10.1111/dth.12119 PubMedCrossRef

158.

Triantafillidis JK, Malgarinos G (2013) Severe psoriasis preceding diagnosis of large bowel Crohn’s disease for 15 years. J Crohns Colitis 7(2):e80. doi:10.1016/j.crohns.2012.07.014 PubMedCrossRef

159.

Trynka G, Hunt KA, Bockett NA, Romanos J, Mistry V, Szperl A et al (2011) Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet 43(12):1193–1201. doi:10.1038/ng.998 PubMedPubMedCentralCrossRef

160.

Tsai TF, Wang TS, Hung ST, Tsai PI, Schenkel B, Zhang M, Tang CH (2011) Epidemiology and comorbidities of psoriasis patients in a national database in Taiwan. J Dermatol Sci 63(1):40–46. doi:10.1016/j.jdermsci.2011.03.002 PubMedCrossRef

161.

Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F et al (2012) Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet 44(12):1341–1348. doi:10.1038/ng.2467 PubMedPubMedCentralCrossRef

162.

Tursi A, Elisei W, Giorgetti GM, Gaspardone A, Lecca PG, Di Cesare L, Brandimarte G (2010) Prevalence of celiac disease and symptoms in relatives of patients with celiac disease. Eur Rev Med Pharmacol Sci 14(6):567–572PubMed

163.

Tuzun B, Wolf R, Tuzun Y, Serdaroglu S (2000) Recurrent aphthous stomatitis and smoking. Int J Dermatol 39(5):358–360. doi:10.1046/j.1365-4362.2000.00963.x PubMedCrossRef

164.

Ucak S, Ekmekci TR, Basat O, Koslu A, Altuntas Y (2006) Comparison of various insulin sensitivity indices in psoriatic patients and their relationship with type of psoriasis. J Eur Acad Dermatol Venereol 20(5):517–522. doi:10.1111/j.1468-3083.2006.01499.x PubMedCrossRef

165.

Ulmansky M, Michelle R, Azaz B (1995) Oral psoriasis: report of six new cases. J Oral Pathol Med 24(1):42–45. doi:10.1111/j.1600-0714.1995.tb01128.x PubMedCrossRef

166.

van Schaik FD, Oldenburg B, Hart AR, Siersema PD, Lindgren S, Grip O, Teucher B, Kaaks R, Bergmann MM, Boeing H, Carbonnel F, Jantchou P, Boutron-Ruault MC, Tjønneland A, Olsen A, Crowe FL, Peeters PH, van Oijen MG, Bueno-de-Mesquita HB (2013) Serological markers predict inflammatory bowel disease years before the diagnosis. Gut 62(5):683–688. doi:10.1136/gutjnl-2012-302717 PubMedCrossRef

167.

Vedak P, Kroshinsky D, St John J, Xavier RJ, Yajnik V, Ananthakrishnan AN (2016) Genetic basis of TNF-alpha antagonist associated psoriasis in inflammatory bowel diseases: a genotype-phenotype analysis. Aliment Pharmacol Ther 43(6):697–704. doi:10.1111/apt.13542 PubMedPubMedCentralCrossRef

168.

Vlachos C, Gaitanis G, Katsanos KH, Christodoulou DK, Tsianos E, Bassukas ID (2016) Psoriasis and inflammatory bowel disease-links and risks. Psoriasis Targets Ther 6:73–92. doi:10.2147/PTT/S85194 CrossRef

169.

Wiedermann CJ, Zelger A (2007) Lymphocytic colitis in a patient with psoriasis responsive to budesonide. Scand J Gastroentero 42(4):538–539. doi:10.1080/00365520600994400 CrossRef

170.

Wolf N, Quaranta M, Prescott NJ, Allen M, Smith R, Burden AD, Worthington J, Griffiths CE, Mathew CG, Barker JN, Capon F, Trembath RC (2008) Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease. J Med Genet 45(2):114–116. doi:10.1136/jmg.2007.053595 PubMedCrossRef

171.

Wollina U, Hansel G, Koch A, Schonlebe J, Kostler E, Haroske G (2008) Tumor necrosis factor-alpha inhibitor-induced psoriasis or psoriasiform exanthemata: first 120 cases from the literature including a series of six new patients. Am J Clin Dermatol 9(1):1–14PubMedCrossRef

172.

Woo WK, McMillan SA, Watson RG, McCluggage WG, Sloan JM, McMillan JC (2004) Coeliac disease-associated antibodies correlate with psoriasis activity. Br J Dermatol 151(4):891–894. doi:10.1111/j.1365-2133.2004.06137.x PubMedCrossRef

173.

Xing X, Liang Y, Sarkar MK, Wolterink L, Swindell WR, Voorhees JJ, Harms PW, Kahlenberg JM, Johnston A, Gudjonsson JE (2016) IL-17 responses are the dominant inflammatory signal linking inverse, erythrodermic, and chronic plaque psoriasis. J Invest Dermatol 136(12):2498–2501. doi:10.1016/j.jid.2016.07.008 PubMedCrossRef

174.

Yang H, Plevy SE, Taylor K, Tyan D, Fischel-Ghodsian N, McElree C, Targan SR, Rotter JI (1999) Linkage of Crohn’s disease to the major histocompatibility complex region is detected by multiple non-parametric analyses. Gut 44(4):519–526. doi:10.1136/gut.44.4.519 PubMedPubMedCentralCrossRef

175.

Yesudian PD, Chalmers RJ, Warren RB, Griffiths CE (2012) In search of oral psoriasis. Arch Dermatol Res 304(1):1–5. doi:10.1007/s00403-011-1175-3 PubMedCrossRef

176.

Younai FS, Phelan JA (1997) Oral mucositis with features of psoriasis: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 84(1):61–67. doi:10.1016/S1079-2104(97)90297-3 PubMedCrossRef

177.

Young HS, Summers AM, Bhushan M, Brenchley PE, Griffiths CE (2004) Single-nucleotide polymorphisms of vascular endothelial growth factor in psoriasis of early onset. J Invest Dermatol 122(1):209–215. doi:10.1046/j.0022-202X.2003.22107.x PubMedCrossRef

178.

Young Park J, Hyun Rim J, Beom Choe Y, Il Youn J (2004) Facial psoriasis: comparison of patients with and without facial involvement. J Am Acad Dermatol 50(4):582–584. doi:10.1016/S0190 PubMedCrossRef

179.

Yu QT, Saruta M, Avanesyan A, Fleshner PR, Banham AH, Papadakis KA (2007) Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis. Inflamm Bowel Dis 13(2):191–199. doi:10.1002/ibd.20053 PubMedCrossRef

180.

Zadik Y, Drucker S, Pallmon S (2011) Migratory stomatitis (ectopic geographic tongue) on the floor of the mouth. J Am Acad Dermatol 65(2):459–460. doi:10.1016/j.jaad.2010.04.016 PubMedCrossRef

181.

Zandman-Goddard G, Peeva E, Shoenfeld Y (2007) Gender and autoimmunity. Autoimmun Rev 6(6):366–372. doi:10.1016/j.autrev.2006.10.001 PubMedCrossRef

182.

Zargari O (2006) The prevalence and significance of fissured tongue and geographical tongue in psoriatic patients. Clin Exp Dermatol 31(2):192–195. doi:10.1111/j.1365-2230.2005.02028.x PubMedCrossRef

183.

Ottas A, Fishman D, Okas TL, Kingo K, Soomets U (2017) The metabolic analysis of psoriasis identifies the associated metabolites while providing computational models for the monitoring of the disease. Arch Dermatol Res. doi:10.1007/s00403-017-1760-1 PubMedPubMedCentral

184.

Hambly R, Kirby B (2017) The relevance of serum vitamin D in psoriasis: a review. Arch Dermatol Res. doi:10.1007/s00403-017-1751-2 PubMed

185.

Mysliwiec H, Baran A, Harasim-Symbor E, Mysliwiec P, Milewska AJ, Chabowski A, Flisiak I (2017) Serum fatty acid profile in psoriasis and its comorbidity. Arch Dermatol Res 309:371–380PubMedPubMedCentralCrossRef

186.

Zander N, Schafer I, Radtke M, Jacobi A, Heigel H, Augustin M (2017) Dermatological comorbidity in psoriasis: results from a large-scale cohort of employees. Arch Dermatol Res 309:349–356PubMedCrossRef

187.

Gutknecht M, Krensel M, Augustin M (2016) Health economic analyses of psoriasis management: a systematic literature search. Arch Dermatol Res 308:601–616PubMedCrossRef

Title: Digestive system in psoriasis: an update
Authors: Daniel Pietrzak
Aldona Pietrzak
Dorota Krasowska
Andrzej Borzęcki
Kinga Franciszkiewicz-Pietrzak
Beata Polkowska-Pruszyńska
Maja Baranowska
Kristian Reich
Publication date: 01-11-2017
Publisher: Springer Berlin Heidelberg
Published in: Archives of Dermatological Research / Issue 9/2017
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-017-1775-7

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Digestive system in psoriasis: an update

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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