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Archives of Orthopaedic and Trauma Surgery

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01-05-2019 | Orthopaedic Surgery

The effects of radiosynoviorthesis in pigmented villonodular synovitis of the knee

Authors: Hans Roland Dürr, Carl Ferdinand Capellen, Alexander Klein, Andrea Baur-Melnyk, Christof Birkenmaier, Volkmar Jansson, Reinhold Tiling

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 5/2019

Abstract

Introduction

Tenosynovial giant-cell tumor also known as pigmented villonodular synovitis (PVS) is a benign but aggressive synovial proliferative disease most often affecting the knee joint. The mainstay of therapy is surgical resection. Due to a high rate of local recurrence, radiosynoviorthesis (RSO) is used as an adjuvant method in many cases. The aim of this study was to compare local recurrence (LR) rates after surgical synovectomy with and without adjuvant RSO.

Materials and methods

From 1996 to 2014, 37 surgical interventions were performed in 32 patients with diffuse pigmented villonodular synovitis of the knee. All patients underwent open synovectomy. Adjuvant radiosynoviorthesis (RSO) was applied in 26 cases, the control group consists of 11 cases without RSO.

Results

9 (24%) lesions recurred within a median of 19 months after surgery. Of those 9 recurrences, 3 (17%) were seen in primary disease, 6 (32%) in already recurring cases (n.s.). In 26 RSO treated patients 6 (23%) recurred, in 11 patients of the control group, 3 (27%) recurred (n.s.).

Conclusions

RSO is effective in PVS as also shown in some smaller reports in the literature. But surgery is still the mainstay of therapy. RSO is not a method of compensating for an insufficient surgical approach, but it may reduce the high rate of LR in patients with large and even recurrent diffuse forms of the disease.

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Title: The effects of radiosynoviorthesis in pigmented villonodular synovitis of the knee
Authors: Hans Roland Dürr
Carl Ferdinand Capellen
Alexander Klein
Andrea Baur-Melnyk
Christof Birkenmaier
Volkmar Jansson
Reinhold Tiling
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Published in: Archives of Orthopaedic and Trauma Surgery / Issue 5/2019
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI: https://doi.org/10.1007/s00402-018-3097-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The effects of radiosynoviorthesis in pigmented villonodular synovitis of the knee

Abstract

Introduction

Materials and methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Materials and methods

Results

Conclusions

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