Skip to main content
Top
Published in: Archives of Orthopaedic and Trauma Surgery 4/2018

01-04-2018 | Orthopaedic Surgery

Long-term outcome of pigmented villonodular synovitis of the hip after joint preserving therapy

Authors: Martin Hufeland, Markus Gesslein, Carsten Perka, Jörg Hartmut Schröder

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 4/2018

Login to get access

Abstract

Introduction

Pigmented villonodular synovitis (PVNS) is a rare, destructive synovial disease that affects the hip joint the second most common after the knee. However, in contrast, joint preserving surgery in the hip joint is considered to be significantly more difficult or even impossible due to earlier occurrence of osteochondral dissemination and surgical difficulties. Today, earlier diagnosis due to the generous use of MRI and modern surgical strategies raise hope for improved outcomes.

Methods

Since 2005, six patients with PVNS of the hip and a minimal follow-up of 2 years underwent joint preserving surgery in our institution (mean age 20.5 years, range 14–27). After PVNS was suspected in the MRI and confirmed by arthroscopic biopsy (four diffuse, two focal forms), synovectomy was carried out in 5 patients via surgical hip dislocation and in one focal case via arthroscopy. In diffuse forms, adjuvant radiosynoviorthesis (RSO) was conducted 6–8 week postoperatively. MRI and clinical examinations were performed during follow-up.

Results

After a mean follow-up of 8 years (range 35–141 months), five of six patients did not show recurrence or secondary osteoarthritis. Clinical outcome evaluation resulted in a mean modified Harris Hip Score of 91 points (range 67–100 points). A 21-year-old patient with a diffuse form and advanced osteochondral involvement at the time of diagnosis was eventually treated by total hip arthroplasty.

Conclusion

In cases without osteochondral involvement, recurrence-free long-term results without progression of joint degeneration can be achieved by joint preserving therapy.
Literature
1.
go back to reference Myers BW, Masi AT (1980) Pigmented villonodular synovitis and tenosynovitis: a clinical epidemiologic study of 166 cases and literature review. Medicine (Baltimore) 59:223–238CrossRef Myers BW, Masi AT (1980) Pigmented villonodular synovitis and tenosynovitis: a clinical epidemiologic study of 166 cases and literature review. Medicine (Baltimore) 59:223–238CrossRef
2.
go back to reference de Visser E, Veth RP, Pruszczynski M, Wobbes T, Van de Putte LB (1999) Diffuse and localized pigmented villonodular synovitis: evaluation of treatment of 38 patients. Arch Orthop Trauma Surg 119:401–404CrossRefPubMed de Visser E, Veth RP, Pruszczynski M, Wobbes T, Van de Putte LB (1999) Diffuse and localized pigmented villonodular synovitis: evaluation of treatment of 38 patients. Arch Orthop Trauma Surg 119:401–404CrossRefPubMed
3.
go back to reference Jaffe H (1941) Pigmented villonodular synovitis, bursitis and tenosynovitis: a discussion of the synovial and bursal equivalents of the tenosynovial lesion commonly denoted as xan-toma, xantogranuloma, giant cell tumor or myeloplaxoma of the tendon sheath itself. Arch Pathol Lab Med 31:731–765 Jaffe H (1941) Pigmented villonodular synovitis, bursitis and tenosynovitis: a discussion of the synovial and bursal equivalents of the tenosynovial lesion commonly denoted as xan-toma, xantogranuloma, giant cell tumor or myeloplaxoma of the tendon sheath itself. Arch Pathol Lab Med 31:731–765
4.
go back to reference Fiocco U, Sfriso P, Lunardi F, Pagnin E, Oliviero F, Scagliori E, Cozzi L, Vezzu M, Molena B, Scanu A, Panziera C, Nardacchione R, Rubaltelli L, Dayer JM, Calabrese F, Punzi L (2010) Molecular pathways involved in synovial cell inflammation and tumoral proliferation in diffuse pigmented villonodular synovitis. Autoimmun Rev 9:780–784CrossRefPubMed Fiocco U, Sfriso P, Lunardi F, Pagnin E, Oliviero F, Scagliori E, Cozzi L, Vezzu M, Molena B, Scanu A, Panziera C, Nardacchione R, Rubaltelli L, Dayer JM, Calabrese F, Punzi L (2010) Molecular pathways involved in synovial cell inflammation and tumoral proliferation in diffuse pigmented villonodular synovitis. Autoimmun Rev 9:780–784CrossRefPubMed
5.
go back to reference Berger I, Aulmann S, Ehemann V, Helmchen B, Weckauf H (2005) Apoptosis resistance in pigmented villonodular synovitis. Histol Histopathol 20:11–17PubMed Berger I, Aulmann S, Ehemann V, Helmchen B, Weckauf H (2005) Apoptosis resistance in pigmented villonodular synovitis. Histol Histopathol 20:11–17PubMed
6.
go back to reference Ijiri K, Tsuruga H, Sakakima H, Tomita K, Taniguchi N, Shimoonoda K, Komiya S, Goldring MB, Majima HJ, Matsuyama T (2005) Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality. Ann Rheum Dis 64:816–823CrossRefPubMed Ijiri K, Tsuruga H, Sakakima H, Tomita K, Taniguchi N, Shimoonoda K, Komiya S, Goldring MB, Majima HJ, Matsuyama T (2005) Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality. Ann Rheum Dis 64:816–823CrossRefPubMed
7.
go back to reference Adams ME, Saifuddin A (2007) Characterisation of intra-articular soft tissue tumours and tumour-like lesions. Eur Radiol Germany 17:950–958CrossRef Adams ME, Saifuddin A (2007) Characterisation of intra-articular soft tissue tumours and tumour-like lesions. Eur Radiol Germany 17:950–958CrossRef
8.
go back to reference Taylor R, Kashima TG, Knowles H, Gibbons CL, Whitwell D, Athanasou NA (2011) Osteoclast formation and function in pigmented villonodular synovitis. J Pathol 225:151–156CrossRefPubMed Taylor R, Kashima TG, Knowles H, Gibbons CL, Whitwell D, Athanasou NA (2011) Osteoclast formation and function in pigmented villonodular synovitis. J Pathol 225:151–156CrossRefPubMed
9.
go back to reference Goldman AB, DiCarlo EF (1988) Pigmented villonodular synovitis. Diagnosis and differential diagnosis. Radiol Clin N Am 26:1327–1347PubMed Goldman AB, DiCarlo EF (1988) Pigmented villonodular synovitis. Diagnosis and differential diagnosis. Radiol Clin N Am 26:1327–1347PubMed
10.
go back to reference Dorwart RH, Genant HK, Johnston WH, Morris JM (1984) Pigmented villonodular synovitis of synovial joints: clinical, pathologic, and radiologic features. AJR Am J Roentgenol 143:877–885CrossRefPubMed Dorwart RH, Genant HK, Johnston WH, Morris JM (1984) Pigmented villonodular synovitis of synovial joints: clinical, pathologic, and radiologic features. AJR Am J Roentgenol 143:877–885CrossRefPubMed
11.
go back to reference van der Heijden L, Piner SR, van de Sande MA (2016) Pigmented villonodular synovitis: a crowdsourcing study of two hundred and seventy-two patients. Int Orthop 40:2459–2468CrossRefPubMed van der Heijden L, Piner SR, van de Sande MA (2016) Pigmented villonodular synovitis: a crowdsourcing study of two hundred and seventy-two patients. Int Orthop 40:2459–2468CrossRefPubMed
12.
go back to reference Flandry F, Hughston JC (1987) Pigmented villonodular synovitis. J Bone Jt Surg Am 69:942–949CrossRef Flandry F, Hughston JC (1987) Pigmented villonodular synovitis. J Bone Jt Surg Am 69:942–949CrossRef
13.
go back to reference Nishida Y, Tsukushi S, Nakashima H, Sugiura H, Yamada Y, Urakawa H, Arai E, Ishiguro N (2012) Osteochondral destruction in pigmented villonodular synovitis during the clinical course. J Rheumatol 39:345–351CrossRefPubMed Nishida Y, Tsukushi S, Nakashima H, Sugiura H, Yamada Y, Urakawa H, Arai E, Ishiguro N (2012) Osteochondral destruction in pigmented villonodular synovitis during the clinical course. J Rheumatol 39:345–351CrossRefPubMed
14.
go back to reference Ottaviani S, Ayral X, Dougados M, Gossec L (2011) Pigmented villonodular synovitis: a retrospective single-center study of 122 cases and review of the literature. Semin Arthritis Rheum 40:539–546CrossRefPubMed Ottaviani S, Ayral X, Dougados M, Gossec L (2011) Pigmented villonodular synovitis: a retrospective single-center study of 122 cases and review of the literature. Semin Arthritis Rheum 40:539–546CrossRefPubMed
15.
go back to reference Mankin H, Trahan C, Hornicek F (2011) Pigmented villonodular synovitis of joints. J Surg Oncol 103:386–389CrossRefPubMed Mankin H, Trahan C, Hornicek F (2011) Pigmented villonodular synovitis of joints. J Surg Oncol 103:386–389CrossRefPubMed
16.
go back to reference Ganz R, Gill TJ, Gautier E, Ganz K, Krügel N, Berlemann U (2001) Surgical dislocation of the adult hip a technique with full access to the femoral head and acetabulum without the risk of avascular necrosis. J Bone Jt Surg Br 83:1119–1124CrossRef Ganz R, Gill TJ, Gautier E, Ganz K, Krügel N, Berlemann U (2001) Surgical dislocation of the adult hip a technique with full access to the femoral head and acetabulum without the risk of avascular necrosis. J Bone Jt Surg Br 83:1119–1124CrossRef
17.
go back to reference Gödde S, Kusma M, Dienst M (2006) Arthroskopische Diagnostik und Therapie synovialer Erkrankungen. Arthroskopie 19:51–58CrossRef Gödde S, Kusma M, Dienst M (2006) Arthroskopische Diagnostik und Therapie synovialer Erkrankungen. Arthroskopie 19:51–58CrossRef
18.
go back to reference Dienst M, Seil R, Kohn DM (2005) Safe arthroscopic access to the central compartment of the hip. Arthroscopy 21:1510–1514CrossRefPubMed Dienst M, Seil R, Kohn DM (2005) Safe arthroscopic access to the central compartment of the hip. Arthroscopy 21:1510–1514CrossRefPubMed
19.
go back to reference Dürr HR, Stäbler A, Maier M, Refior HJ (2001) Pigmented villonodular synovitis. Review of 20 cases. J Rheumatol Canada 28:1620–1630 Dürr HR, Stäbler A, Maier M, Refior HJ (2001) Pigmented villonodular synovitis. Review of 20 cases. J Rheumatol Canada 28:1620–1630
20.
go back to reference Ofluoglu O (2006) Pigmented villonodular synovitis. Orthop Clin N Am 37:23–33CrossRef Ofluoglu O (2006) Pigmented villonodular synovitis. Orthop Clin N Am 37:23–33CrossRef
21.
22.
go back to reference Byrd JW, Jones KS, Maiers GP (2013) Two to 10 years’ follow-up of arthroscopic management of pigmented villonodular synovitis in the hip: a case series. Arthroscopy 29:1783–1787CrossRefPubMed Byrd JW, Jones KS, Maiers GP (2013) Two to 10 years’ follow-up of arthroscopic management of pigmented villonodular synovitis in the hip: a case series. Arthroscopy 29:1783–1787CrossRefPubMed
23.
go back to reference Miller WE (1982) Villonodular synovitis: pigmented and nonpigmented variations. South Med J 75:1084–1086, 1092CrossRefPubMed Miller WE (1982) Villonodular synovitis: pigmented and nonpigmented variations. South Med J 75:1084–1086, 1092CrossRefPubMed
24.
go back to reference Tosun HB, Uludağ A, Serbest S, Gümüştaş S, Erdoğdu IH (2014) A rare case of extensive diffuse nonpigmented villonodular synovitis as a cause of total knee arthroplasty failure. Int J Surg Case Rep 5:419–423CrossRefPubMedPubMedCentral Tosun HB, Uludağ A, Serbest S, Gümüştaş S, Erdoğdu IH (2014) A rare case of extensive diffuse nonpigmented villonodular synovitis as a cause of total knee arthroplasty failure. Int J Surg Case Rep 5:419–423CrossRefPubMedPubMedCentral
25.
go back to reference Matsuda DK, Carlisle JC, Arthurs SC, Wierks CH, Philippon MJ (2011) Comparative systematic review of the open dislocation, mini-open, and arthroscopic surgeries for femoroacetabular impingement. Arthroscopy 27:252–269CrossRefPubMed Matsuda DK, Carlisle JC, Arthurs SC, Wierks CH, Philippon MJ (2011) Comparative systematic review of the open dislocation, mini-open, and arthroscopic surgeries for femoroacetabular impingement. Arthroscopy 27:252–269CrossRefPubMed
27.
go back to reference González Della Valle A, Piccaluga F, Potter HG, Salvati EA, Pusso R (2001) Pigmented villonodular synovitis of the hip: 2- to 23-year followup study. Clin Orthop Relat Res 388:187–199CrossRef González Della Valle A, Piccaluga F, Potter HG, Salvati EA, Pusso R (2001) Pigmented villonodular synovitis of the hip: 2- to 23-year followup study. Clin Orthop Relat Res 388:187–199CrossRef
29.
go back to reference Yen CH, Leung HB, Tse PY (2009) Effects of hip joint position and intra-capsular volume on hip joint intra-capsular pressure: a human cadaveric model. J Orthop Surg Res 4:8CrossRefPubMedPubMedCentral Yen CH, Leung HB, Tse PY (2009) Effects of hip joint position and intra-capsular volume on hip joint intra-capsular pressure: a human cadaveric model. J Orthop Surg Res 4:8CrossRefPubMedPubMedCentral
30.
go back to reference Cotten A, Flipo RM, Chastanet P, Desvigne-Noulet MC, Duquesnoy B, Delcambre B (1995) Pigmented villonodular synovitis of the hip: review of radiographic features in 58 patients. Skeletal Radiol 24:1–6CrossRefPubMed Cotten A, Flipo RM, Chastanet P, Desvigne-Noulet MC, Duquesnoy B, Delcambre B (1995) Pigmented villonodular synovitis of the hip: review of radiographic features in 58 patients. Skeletal Radiol 24:1–6CrossRefPubMed
31.
go back to reference Vastel L, Lambert P, De Pinieux G, Charrois O, Kerboull M, Courpied JP (2005) Surgical treatment of pigmented villonodular synovitis of the hip. J Bone Jt Surg Am 87:1019–1024CrossRef Vastel L, Lambert P, De Pinieux G, Charrois O, Kerboull M, Courpied JP (2005) Surgical treatment of pigmented villonodular synovitis of the hip. J Bone Jt Surg Am 87:1019–1024CrossRef
32.
go back to reference Gitelis S, Heligman D, Morton T (1989) The treatment of pigmented villonodular synovitis of the hip. A case report and literature review. Clin Orthop Relat Res 239:154–160 Gitelis S, Heligman D, Morton T (1989) The treatment of pigmented villonodular synovitis of the hip. A case report and literature review. Clin Orthop Relat Res 239:154–160
33.
go back to reference Schwartz HS, Unni KK, Pritchard DJ (1989) Pigmented villonodular synovitis. A retrospective review of affected large joints. Clin Orthop Relat Res 247:243–255 Schwartz HS, Unni KK, Pritchard DJ (1989) Pigmented villonodular synovitis. A retrospective review of affected large joints. Clin Orthop Relat Res 247:243–255
34.
go back to reference Levy DM, Haughom BD, Nho SJ, Gitelis S (2016) Pigmented villonodular synovitis of the hip: a systematic review. Am J Orthop (Belle Mead NJ) 45(1):23–28 Levy DM, Haughom BD, Nho SJ, Gitelis S (2016) Pigmented villonodular synovitis of the hip: a systematic review. Am J Orthop (Belle Mead NJ) 45(1):23–28
35.
go back to reference Dines JS, DeBerardino TM, Wells JL, Dodson CC, Shindle M, DiCarlo EF, Warren RF (2007) Long-term follow-up of surgically treated localized pigmented villonodular synovitis of the knee. Arthroscopy 23:930–937CrossRefPubMed Dines JS, DeBerardino TM, Wells JL, Dodson CC, Shindle M, DiCarlo EF, Warren RF (2007) Long-term follow-up of surgically treated localized pigmented villonodular synovitis of the knee. Arthroscopy 23:930–937CrossRefPubMed
36.
go back to reference Loriaut P, Djian P, Boyer T, Bonvarlet JP, Delin C, Makridis KG (2012) Arthroscopic treatment of localized pigmented villonodular synovitis of the knee. Knee Surg Sports Traumatol Arthrosc 20:1550–1553CrossRefPubMed Loriaut P, Djian P, Boyer T, Bonvarlet JP, Delin C, Makridis KG (2012) Arthroscopic treatment of localized pigmented villonodular synovitis of the knee. Knee Surg Sports Traumatol Arthrosc 20:1550–1553CrossRefPubMed
37.
go back to reference De Ponti A, Sansone V, Malcherè M (2003) Result of arthroscopic treatment of pigmented villonodular synovitis of the knee. Arthroscopy 19:602–607CrossRefPubMed De Ponti A, Sansone V, Malcherè M (2003) Result of arthroscopic treatment of pigmented villonodular synovitis of the knee. Arthroscopy 19:602–607CrossRefPubMed
38.
go back to reference Rhee PC, Sassoon AA, Sayeed SA, Stuart MS, Dahm DL (2010) Arthroscopic treatment of localized pigmented villonodular synovitis: long-term functional results. Am J Orthop (Belle Mead NJ) 39:E90–E94 Rhee PC, Sassoon AA, Sayeed SA, Stuart MS, Dahm DL (2010) Arthroscopic treatment of localized pigmented villonodular synovitis: long-term functional results. Am J Orthop (Belle Mead NJ) 39:E90–E94
39.
go back to reference Mella C, Lara J, Parodi D, Moya L, Nuñez A (2010) Arthroscopic treatment of an intra-articular tumor of the hip joint. Orthopade 39:512–515CrossRefPubMed Mella C, Lara J, Parodi D, Moya L, Nuñez A (2010) Arthroscopic treatment of an intra-articular tumor of the hip joint. Orthopade 39:512–515CrossRefPubMed
40.
go back to reference Lee S, Haro MS, Riff A, Bush-Joseph CA, Nho SJ (2015) Arthroscopic technique for the treatment of pigmented villonodular synovitis of the hip. Arthrosc Tech 4:e41–e46CrossRefPubMedPubMedCentral Lee S, Haro MS, Riff A, Bush-Joseph CA, Nho SJ (2015) Arthroscopic technique for the treatment of pigmented villonodular synovitis of the hip. Arthrosc Tech 4:e41–e46CrossRefPubMedPubMedCentral
41.
go back to reference Carl HD, Schraml A, Swoboda B, Hohenberger G (2007) Synovectomy of the hip in patients with juvenile rheumatoid arthritis. J Bone Jt Surg Am 89:1986–1992CrossRef Carl HD, Schraml A, Swoboda B, Hohenberger G (2007) Synovectomy of the hip in patients with juvenile rheumatoid arthritis. J Bone Jt Surg Am 89:1986–1992CrossRef
42.
go back to reference Chin KR, Barr SJ, Winalski C, Zurakowski D, Brick GW (2002) Treatment of advanced primary and recurrent diffuse pigmented villonodular synovitis of the knee. J Bone Jt Surg Am 84-A:2192–2202CrossRef Chin KR, Barr SJ, Winalski C, Zurakowski D, Brick GW (2002) Treatment of advanced primary and recurrent diffuse pigmented villonodular synovitis of the knee. J Bone Jt Surg Am 84-A:2192–2202CrossRef
43.
go back to reference Kat S, Kutz R, Elbracht T, Weseloh G, Kuwert T (2000) Radiosynovectomy in pigmented villonodular synovitis. Nuklearmedizin 39:209–213PubMed Kat S, Kutz R, Elbracht T, Weseloh G, Kuwert T (2000) Radiosynovectomy in pigmented villonodular synovitis. Nuklearmedizin 39:209–213PubMed
44.
go back to reference Kresnik E, Mikosch P, Gallowitsch HJ, Jesenko R, Just H, Kogler D, Gasser J, Heinisch M, Unterweger O, Kumnig G, Gomez I, Lind P (2002) Clinical outcome of radiosynoviorthesis: a meta-analysis including 2190 treated joints. Nucl Med Commun 23:683–688CrossRefPubMed Kresnik E, Mikosch P, Gallowitsch HJ, Jesenko R, Just H, Kogler D, Gasser J, Heinisch M, Unterweger O, Kumnig G, Gomez I, Lind P (2002) Clinical outcome of radiosynoviorthesis: a meta-analysis including 2190 treated joints. Nucl Med Commun 23:683–688CrossRefPubMed
45.
go back to reference Shabat S, Kollender Y, Merimsky O, Isakov J, Flusser G, Nyska M, Meller I (2002) The use of surgery and yttrium 90 in the management of extensive and diffuse pigmented villonodular synovitis of large joints. Rheumatology 41:1113–1118CrossRefPubMed Shabat S, Kollender Y, Merimsky O, Isakov J, Flusser G, Nyska M, Meller I (2002) The use of surgery and yttrium 90 in the management of extensive and diffuse pigmented villonodular synovitis of large joints. Rheumatology 41:1113–1118CrossRefPubMed
46.
go back to reference Bruns J, Ewerbeck V, Dominkus M, Windhager R, Hassenpflug J, Windhagen H, Hovy L, Loehr J, Krauspe R, Duerr HR (2013) Pigmented villo-nodular synovitis and giant-cell tumor of tendon sheaths: a binational retrospective study. Arch Orthop Trauma Surg 133:1047–1053CrossRefPubMed Bruns J, Ewerbeck V, Dominkus M, Windhager R, Hassenpflug J, Windhagen H, Hovy L, Loehr J, Krauspe R, Duerr HR (2013) Pigmented villo-nodular synovitis and giant-cell tumor of tendon sheaths: a binational retrospective study. Arch Orthop Trauma Surg 133:1047–1053CrossRefPubMed
Metadata
Title
Long-term outcome of pigmented villonodular synovitis of the hip after joint preserving therapy
Authors
Martin Hufeland
Markus Gesslein
Carsten Perka
Jörg Hartmut Schröder
Publication date
01-04-2018
Publisher
Springer Berlin Heidelberg
Published in
Archives of Orthopaedic and Trauma Surgery / Issue 4/2018
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI
https://doi.org/10.1007/s00402-017-2864-y

Other articles of this Issue 4/2018

Archives of Orthopaedic and Trauma Surgery 4/2018 Go to the issue