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Archives of Orthopaedic and Trauma Surgery
Published in: Archives of Orthopaedic and Trauma Surgery 6/2008

01-06-2008 | Orthopaedic Surgery

Histological osseointegration of Tutobone®: first results in human

Authors: Stephanie Meyer, Thilo Floerkemeier, Henning Windhagen

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 6/2008

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Abstract

The aim of this study was to evaluate the histological and radiological osseointegration characteristics of implanted solvent-preserved cancellous bovine bone substitution material Tutobone® after opening-wedge osteotomy and hip arthroplasty in human. The baseline hypothesis connected to the usage of bovine bone substitute materials is the assumption of temporary structural support, integration in the surrounding bone, bioresorption and replacement with vital bone. This hypothesis is based on numerous studies evaluating sintered bovine grafts showing good osseointegration and stability. Studies analyzing cancellous bovine grafts such as Tutobone® hardly exist. The only rabbit defect model showed 100% remodeling of Tutobone® after 26 weeks. However, no histological data are available on application of this xenograft in patients. In this study, nine patients biopsies were collected about 11 months after application of Tutobone®. Unlike animal studies, the results showed incorporated avital graft remnants (47%) as well as new bone formation (53%) of the total mineralized area. Radiological evaluation confirmed increasing signs of osseointegration and an incomplete resorption. In conclusion, degradation and replacement of bovine graft seems to be less accelerated in patients than the animal study indicated. Nevertheless, Tutobone® shows an excellent biocompatibility, good osteoconductive characteristics and may represent a useful alternative to autogenous graft.
Literature
1.
Arrington ED, Smith WJ, Chambers HG, Bucknell AL, Davino NA (1996) Complications of iliac crest bone graft harvesting. Clin Orthop Relat Res 329:300–309PubMedCrossRef
2.
Bloemers FW, Blokhuis TJ, Patka P, Bakker FC, Wippermann BW, Haarman HJ (2003) Autologous bone versus calcium-phosphate ceramics in treatment of experimental bone defects. J Biomed Mater Res B Appl Biomater 66:526–531PubMedCrossRef
3.
Briem D, Linhart W, Lehmann W, Meenen NM, Rueger JM (2002) Long-term outcomes after using porous hydroxyapatite ceramics (Endobon) for surgical management of fractures of the head of the tibia. Unfallchirurg 105:128–133PubMedCrossRef
4.
Diringer H, Braig HR (1989) Infectivity of unconventional viruses in dura mater. Lancet 1:439–440PubMedCrossRef
5.
Gunther KP, Scharf H-P, Pesch H-J, Puhl W (1996) Osteointegration lösungsmittelkonservierter Knochentransplantate im Tiermodell. Osteologie 5:4–12
6.
Gunther KP, Scharf H-P, Puhl W (1998) Osteointegration einer Trikalziumphosphatkeramik und unterschiedlich konservierter Knochentransplantate im Tierexperiment. Hefte zu “der Unfallchirurg”: Biodegradierbare Implantate und Materialien: 265
7.
Hartl A, Bitzan P, Wanivenhaus A, Kotz R (2004) Faster integration of human allograft bone than of the bovine substitute Lubboc: non-randomized evaluation of 20 cases with benign tumors or tumor-like conditions. Acta Orthop Scand 75:217–220PubMedCrossRef
8.
Helber MU, Ulrich C (2000) Metaphyseal defect substitute: hydroxylapatite ceramic. Results of a 3 to 4 year follow-up Unfallchirurg 103:749–753PubMedCrossRef
9.
Levai JP, Bringer O, Descamps S, Boisgard S (2003) Xenograft-related complications after filling valgus open wedge tibial osteotomy defects. Rev Chir Orthop Reparatrice Appar Mot 89:707–711PubMed
10.
Morax S, Hurbli T, Smida R (1993) Bovine heterologous bone graft in orbital surgery. Ann Chir Plast Esthet 38:445–450PubMed
11.
Pohl S (2004) Konsolidierungsverhalten von xenogener Spongiosa, PhD Dissertation, University of Munich Klinikum rechts der Isar, Department of Trauma Surgery
12.
Rajan GP, Fornaro J, Trentz O, Zellweger R (2006) Cancellous allograft versus autologous bone grafting for repair of comminuted distal radius fractures: a prospective, randomized trial. J Trauma 60:1322–1329PubMedCrossRef
13.
Rueger JM, Linhart W, Sommerfeldt D (1998) Biologic reactions to calcium phosphate ceramic implantations. Results of animal experiments. Orthopade 27:89–95PubMed
14.
Sarkar MR, Wachter N, Patka P, Kinzl L (2001) First histological observations on the incorporation of a novel calcium phosphate bone substitute material in human cancellous bone. J Biomed Mater Res 58:329–334PubMedCrossRef
15.
Schenk RK (1991) Zur Problematik der Knochenersatzstoffe: Histophysiologie des Knochenumbaus und der Substitution von Knochenerstazstoffen. Hefte Unfallheilkd 216:23
16.
17.
Tadic D, Beckmann F, Donath T, Epple M (2004) Comparison of different methods for the preparation of porous bone substitution materials and structural investigations by synchrotron-computer tomography. Materwiss Werksttech 35:240–244CrossRef
18.
Thull R, Sturm A, Pesch H-J (1993) Mechanische Eigenschaften nativer und präparierter Spongiosa. In: Pesch HJ, Stöß H, Kummer B (eds) Osteologie aktuell VII. Springer, Heidelberg, pp 157–163
19.
Werber KD, Brauer RB, Weiss W, Becker K (2000) Osseous integration of bovine hydroxyapatite ceramic in metaphyseal bone defects of the distal radius. J Hand Surg [Am] 25:833–841CrossRef
Metadata
Title
Histological osseointegration of Tutobone®: first results in human
Authors
Stephanie Meyer
Thilo Floerkemeier
Henning Windhagen
Publication date
01-06-2008
Publisher
Springer-Verlag
Published in
Archives of Orthopaedic and Trauma Surgery / Issue 6/2008
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI
https://doi.org/10.1007/s00402-007-0402-z

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