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Open Access 01-09-2020 | COVID-19 | Correspondence

Microvascular injury and hypoxic damage: emerging neuropathological signatures in COVID-19

Authors: Zane Jaunmuktane, Ula Mahadeva, Anna Green, Vivek Sekhawat, Nicholas A. Barrett, Lucy Childs, Manu Shankar-Hari, Maria Thom, Hans Rolf Jäger, Sebastian Brandner

Published in: Acta Neuropathologica | Issue 3/2020

Excerpt

In patients with COVID-19, neurological complications are increasingly recognised, but only few neuropathological studies are available, documenting microthrombi and acute infarcts [1], hypoxic changes with no specific pathology [9] or perivascular lymphocytic infiltration in brainstem [10]. We report here neuropathology of two COVID-19 patients with findings in one strikingly similar to those described in a recent case report, with neocortical infarcts and small haemorrhagic and non-haemorrhagic white matter lesions [8], suggesting an emerging pattern of characteristic alterations, also observed radiologically [3]. …

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Bryce C, Grimes Z, Pujadas E, Ahuja S, Beasley MB, Albrecht R, Hernandez T, Stock A, Zhao Z, Al Rasheed M et al (2020) Pathophysiology of SARS-CoV-2: targeting of endothelial cells renders a complex disease with thrombotic microangiopathy and aberrant immune response. The Mount Sinai COVID-19 autopsy experience. medRxiv: 2020.2005.2018.20099960. https://doi.org/10.1101/2020.05.18.20099960

Choi JY, Lee HK, Park JH, Cho SJ, Kwon M, Jo C, Koh YH (2020) Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke. Biochem Biophys Res Commun. https://doi.org/10.1016/j.bbrc.2020.05.203CrossRefPubMedPubMedCentral

Kremer S, Lersy F, de Sèze J, Ferré JC, Maamar A, Carsin-Nicol B, Collange O, Bonneville F, Adam G, Martin-Blondel G et al (2020) Brain MRI Findings in Severe COVID-19: A Retrospective Observational Study. Radiology: 202222. https://doi.org/10.1148/radiol.2020202222

Lorusso R, Gelsomino S, Parise O, Di Mauro M, Barili F, Geskes G, Vizzardi E, Rycus PT, Muellenbach R, Mueller T et al (2017) Neurologic injury in adults supported with veno-venous extracorporeal membrane oxygenation for respiratory failure: findings from the extracorporeal life support organization database. Crit Care Med 45:1389–1397. https://doi.org/10.1097/ccm.0000000000002502CrossRefPubMed

Magro C, Mulvey JJ, Berlin D, Nuovo G, Salvatore S, Harp J, Baxter-Stoltzfus A, Laurence J (2020) Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases. Translational research : the journal of laboratory and clinical medicine 220:1–13. https://doi.org/10.1016/j.trsl.2020.04.007CrossRef

Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J, Ueno M, Sakata H, Kondo K, Myose N et al (2020) A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis IJID Off Publ Int Soc Infect Dis 94:55–58. https://doi.org/10.1016/j.ijid.2020.03.062CrossRef

Puelles VG, Lütgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, Chilla S, Heinemann A, Wanner N, Liu S et al (2020) Multiorgan and renal tropism of SARS-CoV-2. N Engl J Med. https://doi.org/10.1056/NEJMc2011400CrossRefPubMedPubMedCentral

Reichard RR, Kashani KB, Boire NA, Constantopoulos E, Guo Y, Lucchinetti CF (2020) Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology. Acta Neuropathol. https://doi.org/10.1007/s00401-020-02166-2CrossRefPubMedPubMedCentral

Solomon IH, Normandin E, Bhattacharyya S, Mukerji SS, Keller K, Ali AS, Adams G, Hornick JL, Padera RF, Sabeti P (2020) Neuropathological Features of Covid-19. N Engl Journal Med. https://doi.org/10.1056/NEJMc2019373CrossRef

10.

von Weyhern CH, Kaufmann I, Neff F, Kremer M (2020) Early evidence of pronounced brain involvement in fatal COVID-19 outcomes. Lancet (Lond Engl). https://doi.org/10.1016/s0140-6736(20)31282-4CrossRef

Title: Microvascular injury and hypoxic damage: emerging neuropathological signatures in COVID-19
Authors: Zane Jaunmuktane
Ula Mahadeva
Anna Green
Vivek Sekhawat
Nicholas A. Barrett
Lucy Childs
Manu Shankar-Hari
Maria Thom
Hans Rolf Jäger
Sebastian Brandner
Publication date: 01-09-2020
Publisher: Springer Berlin Heidelberg
Keyword: COVID-19
Published in: Acta Neuropathologica / Issue 3/2020
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-020-02190-2

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Microvascular injury and hypoxic damage: emerging neuropathological signatures in COVID-19

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Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

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