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Open Access 01-07-2018 | Original Paper

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

Authors: Maitrayee Sardar Sinha, Anna Ansell-Schultz, Livia Civitelli, Camilla Hildesjö, Max Larsson, Lars Lannfelt, Martin Ingelsson, Martin Hallbeck

Published in: Acta Neuropathologica | Issue 1/2018

Abstract

The gradual deterioration of cognitive functions in Alzheimer’s disease is paralleled by a hierarchical progression of amyloid-beta and tau brain pathology. Recent findings indicate that toxic oligomers of amyloid-beta may cause propagation of pathology in a prion-like manner, although the underlying mechanisms are incompletely understood. Here we show that small extracellular vesicles, exosomes, from Alzheimer patients’ brains contain increased levels of amyloid-beta oligomers and can act as vehicles for the neuron-to-neuron transfer of such toxic species in recipient neurons in culture. Moreover, blocking the formation, secretion or uptake of exosomes was found to reduce both the spread of oligomers and the related toxicity. Taken together, our results imply that exosomes are centrally involved in Alzheimer’s disease and that they could serve as targets for development of new diagnostic and therapeutic principles.

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Title: Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
Authors: Maitrayee Sardar Sinha
Anna Ansell-Schultz
Livia Civitelli
Camilla Hildesjö
Max Larsson
Lars Lannfelt
Martin Ingelsson
Martin Hallbeck
Publication date: 01-07-2018
Publisher: Springer Berlin Heidelberg
Published in: Acta Neuropathologica / Issue 1/2018
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-018-1868-1

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Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

Abstract

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Abstract

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