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Acta Neuropathologica
Published in: Acta Neuropathologica 5/2010

01-05-2010 | Review

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

Authors: Gunnar K. Gouras, Davide Tampellini, Reisuke H. Takahashi, Estibaliz Capetillo-Zarate

Published in: Acta Neuropathologica | Issue 5/2010

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Abstract

The aberrant accumulation of aggregated β-amyloid peptides (Aβ) as plaques is a hallmark of Alzheimer’s disease (AD) neuropathology and reduction of Aβ has become a leading direction of emerging experimental therapies for the disease. The mechanism(s) whereby Aβ is involved in the pathophysiology of the disease remain(s) poorly understood. Initially fibrils, and subsequently oligomers of extracellular Aβ have been viewed as the most important pathogenic form of Aβ in AD. More recently, the intraneuronal accumulation of Aβ has been described in the brain, although technical considerations and its relevance in AD have made this a controversial topic. Here, we review the emerging evidence linking intraneuronal Aβ accumulation to the development of synaptic pathology and plaques in AD, and discuss the implications of intraneuronal β-amyloid for AD pathology, biology, diagnosis and therapy.
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Metadata
Title
Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease
Authors
Gunnar K. Gouras
Davide Tampellini
Reisuke H. Takahashi
Estibaliz Capetillo-Zarate
Publication date
01-05-2010
Publisher
Springer-Verlag
Published in
Acta Neuropathologica / Issue 5/2010
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-010-0679-9

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