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01-04-2018 | Correspondence

cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutant

Authors: David N. Louis, Caterina Giannini, David Capper, Werner Paulus, Dominique Figarella-Branger, M. Beatriz Lopes, Tracy T. Batchelor, J. Gregory Cairncross, Martin van den Bent, Wolfgang Wick, Pieter Wesseling

Published in: Acta Neuropathologica | Issue 4/2018

Excerpt

The major changes in brain tumor classification arise through the World Health Organization (WHO) classification update process. To provide possible guidelines for practicing diagnosticians between WHO updates and to facilitate future WHO classification updates, cIMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy—Not Official WHO) was established. Since its creation in 2016, cIMPACT-NOW (cIMPACT for short) has convened three working committees to address ongoing classification and grading challenges. In addition to addressing questions about the use of the NOS (Not Otherwise Specified) suffix, Working Committee 3 clarified diagnostic criteria for the following entities: Diffuse midline glioma, H3 K27M-mutant; diffuse astrocytoma, IDH-mutant; and anaplastic astrocytoma, IDH-mutant. The present correspondence reports the recommendations of cIMPACT Working Committee 3 clarifying diagnostic criteria for these entities. …

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Title: cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutant
Authors: David N. Louis
Caterina Giannini
David Capper
Werner Paulus
Dominique Figarella-Branger
M. Beatriz Lopes
Tracy T. Batchelor
J. Gregory Cairncross
Martin van den Bent
Wolfgang Wick
Pieter Wesseling
Publication date: 01-04-2018
Publisher: Springer Berlin Heidelberg
Published in: Acta Neuropathologica / Issue 4/2018
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-018-1826-y

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