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01-02-2016 | Erratum

Erratum to: Gliomatosis cerebri: no evidence for a separate brain tumor entity

Authors: Ulrich Herrlinger, David T. W. Jones, Martin Glas, Elke Hattingen, Dorothee Gramatzki, Moritz Stuplich, Jörg Felsberg, Oliver Bähr, Gerrit H. Gielen, Matthias Simon, Dorothee Wiewrodt, Martin Schabet, Volker Hovestadt, David Capper, Joachim P. Steinbach, Andreas von Deimling, Peter Lichter, Stefan M. Pfister, Michael Weller, Guido Reifenberger

Published in: Acta Neuropathologica | Issue 2/2016

Excerpt

The original version of this article contained errors in the alignment of several entries in Tables 4 and 5. The corrected Tables 4 and 5 are given below. The original article has been updated accordingly.

Table 4

Univariate and multivariate Cox regression analysis regarding overall survival and single genetic factors

	Median survival in months		Risk ratio (lower–upper 95 % CI)	p
	Condition 1	Condition 2	Condition 1 vs. condition 2	p
Univariate analysis
MGMT promoter status	Methylated	Unmethylated	0.09 (0.02–0.44)	0.004
MGMT promoter status	>37.1	8.9	0.09 (0.02–0.44)	0.004
IDH/CIMP status	Mutant/positive	Wildtype/negative	0.31 (0.08–1.23)	0.08
IDH/CIMP status	36.3	14.1
1p/19q status	Codeleted	Not codeleted
1p/19q status	>16.5	34.8	0.44 (0.05–3.6)	0.44
Chromosome 7 gain	Yes	No	6.32 (1.78–22.5)	0.004
Chromosome 7 gain	8.98	>36.3	6.32 (1.78–22.5)	0.004
EGFR amplification	Yes	No	10.1 (2.0–51.1)	0.005
EGFR amplification	7.9	36.3	10.1 (2.0–51.1)	0.005
9p21 deletion	Yes	No	1.15 (0.33–4.0)	0.82
9p21 deletion	37.1	34.6	1.15 (0.33–4.0)	0.82
Chromosome 10 deletion	Yes	No	2.6 (0.77–8.73)	0.12
Chromosome 10 deletion	12.2	36.3	2.6 (0.77–8.73)	0.12
CDK4 amplification	Yes	No	0.52 (0.1–2.6)	0.42
CDK4 amplification	36.2	34.6	0.52 (0.1–2.6)	0.42
MDM2 or MDM4 amplification	Yes	No	1.06 (0.28–4.1)	0.93
MDM2 or MDM4 amplification	14.1	34.6	1.06 (0.28–4.1)	0.93
Multivariate analysis
MGMT promoter status	Methylated	Unmethylated	0.16 (0.03–0.95)	0.04
IDH/CIMP status	Mutant/positive	Wildtype/negative	1.27 (0.14–11.6)	0.83
Chromosome 7 gain	Yes	No	4.2 (0.49–36.3)	0.19
EGFR amplification	Yes	No	3.0 (0.56–16.3)	0.20

Significant p values lower than 0.05 are in bold

Table 5

Univariate Cox regression analysis regarding the prognostic value MRI features for overall survival

MRI appearance	HR	95 % CI	p
Infratentorial involvement, yes vs. no	0.4	0.05–3.1	0.38
Involvement of 6 or more lobes, yes vs. no	1.08	0.33–3.5	0.9
Bilateral involvement, yes vs. no	0.67	0.08–5.4	0.71
Contrast enhancing lesions^a, yes vs. no	1.39	0.37–5.3	0.63

HR hazard ratio, CI confidence interval

^aOn the first MRI fulfilling the criteria of GC

…

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Erratum to: Gliomatosis cerebri: no evidence for a separate brain tumor entity

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ACC 2024 Congress

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