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Acta Neuropathologica
Published in: Acta Neuropathologica 2/2016

Open Access 01-02-2016 | Review

Host–pathogen interactions in bacterial meningitis

Authors: Kelly S. Doran, Marcus Fulde, Nina Gratz, Brandon J. Kim, Roland Nau, Nemani Prasadarao, Alexandra Schubert-Unkmeir, Elaine I. Tuomanen, Peter Valentin-Weigand

Published in: Acta Neuropathologica | Issue 2/2016

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Abstract

Bacterial meningitis is a devastating disease occurring worldwide with up to half of the survivors left with permanent neurological sequelae. Due to intrinsic properties of the meningeal pathogens and the host responses they induce, infection can cause relatively specific lesions and clinical syndromes that result from interference with the function of the affected nervous system tissue. Pathogenesis is based on complex host–pathogen interactions, some of which are specific for certain bacteria, whereas others are shared among different pathogens. In this review, we summarize the recent progress made in understanding the molecular and cellular events involved in these interactions. We focus on selected major pathogens, Streptococcus pneumonia, S. agalactiae (Group B Streptococcus), Neisseria meningitidis, and Escherichia coli K1, and also include a neglected zoonotic pathogen, Streptococcus suis. These neuroinvasive pathogens represent common themes of host–pathogen interactions, such as colonization and invasion of mucosal barriers, survival in the blood stream, entry into the central nervous system by translocation of the blood–brain and blood–cerebrospinal fluid barrier, and induction of meningeal inflammation, affecting pia mater, the arachnoid and subarachnoid spaces.
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Metadata
Title
Host–pathogen interactions in bacterial meningitis
Authors
Kelly S. Doran
Marcus Fulde
Nina Gratz
Brandon J. Kim
Roland Nau
Nemani Prasadarao
Alexandra Schubert-Unkmeir
Elaine I. Tuomanen
Peter Valentin-Weigand
Publication date
01-02-2016
Publisher
Springer Berlin Heidelberg
Published in
Acta Neuropathologica / Issue 2/2016
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-015-1531-z

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