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Published in: Acta Neuropathologica 3/2014

01-03-2014 | Commentary Letter

TMEM106B: a strong FTLD disease modifier

Authors: Yuetiva Deming, Carlos Cruchaga

Published in: Acta Neuropathologica | Issue 3/2014

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Excerpt

Genome-wide association studies (GWAS) are a very powerful approach for identifying novel loci associated with disease risk or other complex traits. In these studies millions of common single-nucleotide polymorphisms (SNPs), distributed across the whole genome, are analyzed for their association against disease status. The power of these studies is that it is not necessary to have an a priori hypothesis about the potential implication of any particular gene with disease status. This approach has successfully identified novel genes implicated in several neurodegenerative diseases including Alzheimer’s disease [7], Parkinson’s disease [8], frontotemporal dementia [13], progressive supranuclear palsy [6], and others. The importance of these studies is the identification of novel genes and pathways implicated in disease. The identification of these genes has led to a better understanding of disease pathogenesis and the potential identification of novel biomarkers and therapeutic targets. …
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Metadata
Title
TMEM106B: a strong FTLD disease modifier
Authors
Yuetiva Deming
Carlos Cruchaga
Publication date
01-03-2014
Publisher
Springer Berlin Heidelberg
Published in
Acta Neuropathologica / Issue 3/2014
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-014-1249-3

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