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Acta Neuropathologica
Published in: Acta Neuropathologica 6/2010

01-12-2010 | Correspondence

Heterogeneous neuropathological findings in Parkinson’s disease with mild cognitive impairment

Authors: Charles H. Adler, John N. Caviness, Marwan N. Sabbagh, Holly A. Shill, Donald J. Connor, Lucia Sue, Virgilio G. H. Evidente, Erika Driver-Dunckley, Thomas G. Beach

Published in: Acta Neuropathologica | Issue 6/2010

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Excerpt

Parkinson’s disease (PD) patients often develop mild cognitive impairment (PD-MCI) and dementia (PDD) [5, 8]. The pathologic substrate for PDD appears to be heterogeneous and includes Lewy bodies, Alzheimer’s disease (AD) pathology, and cerebrovascular disease [6, 7, 9, 10]. Neuropathological changes in PD-MCI have not been described. …
Literature
1.
Aarsland D, Perry R, Brown A, Larsen JP, Ballard C (2005) Neuropathology of dementia in Parkinson’s disease: a prospective, community-based study. Ann Neurol 58:773–776CrossRefPubMed
2.
Adler CH, Hentz JG, Joyce JN, Beach T, Caviness JN (2002) Motor impairment in normal aging, clinically possible Parkinson’s disease, and clinically probable Parkinson’s disease: longitudinal evaluation of a cohort of prospective brain donors. Parkinsonism Relat Disord 9:103–110CrossRefPubMed
3.
Beach TG, Adler CH, Lue L et al (2009) Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathol 117:613–634CrossRefPubMed
4.
Beach TG, Sue LI, Walker DG et al (2008) The Sun Health Research Institute Brain Donation Program: description and experience, 1987–2007. Cell Tissue Bank 9:229–245CrossRefPubMed
5.
Caviness JN, Driver-Dunckley E, Connor DJ et al (2007) Defining mild cognitive impairment in Parkinson’s disease. Mov Disord 22:1272–1277CrossRefPubMed
6.
Choi SA, Evidente VG, Caviness JN et al (2010) Are there differences in cerebral white matter lesion burdens between Parkinson’s disease patients with or without dementia? Acta Neuropathol 119:147–149CrossRefPubMed
7.
Hurtig HI, Trojanowski JQ, Galvin J et al (2000) Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson’s disease. Neurology 54:1916–1921PubMed
8.
Janvin CC, Larsen JP, Aarsland D, Hugdahl K (2006) Subtypes of mild cognitive impairment in Parkinson’s disease: progression to dementia. Mov Disord 21:1343–1349CrossRefPubMed
9.
Jellinger KA (2006) Pathological substrate of dementia in Parkinson’s disease–its relation to DLB and DLBD. Parkinsonism Relat Disord 12:119–120CrossRefPubMed
10.
Sabbagh MN, Adler CH, Lahti TJ et al (2009) Parkinson disease with dementia: comparing patients with and without Alzheimer pathology. Alzheimer Dis Assoc Disord 23:295–297CrossRefPubMed
11.
Sabbagh MN, Shah F, Reid RT et al (2006) Pathologic and nicotinic receptor binding differences between mild cognitive impairment, Alzheimer disease, and normal aging. Arch Neurol 63:1771–1776CrossRefPubMed
Metadata
Title
Heterogeneous neuropathological findings in Parkinson’s disease with mild cognitive impairment
Authors
Charles H. Adler
John N. Caviness
Marwan N. Sabbagh
Holly A. Shill
Donald J. Connor
Lucia Sue
Virgilio G. H. Evidente
Erika Driver-Dunckley
Thomas G. Beach
Publication date
01-12-2010
Publisher
Springer-Verlag
Published in
Acta Neuropathologica / Issue 6/2010
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-010-0744-4

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