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01-01-2010 | Correspondence

The neuropathologic substrate of Parkinson disease dementia

Author: Kurt A. Jellinger

Published in: Acta Neuropathologica | Issue 1/2010

Excerpt

In their recent review about the morbid anatomy of dementia, Kalaitzakis and Pearce [24] critically discussed the impact of both cortical α-synuclein (αSyn) and Alzheimer disease (AD) pathologies and the molecular interactions between αSyn, tau, and Aβ proteins in the development of cognitive impairment in Parkinson disease (PD), suggesting a linked pathological cascade of AD- and PD-related mechanisms. This commentary is intended (1) to confirm most of the statements of this review and (2) to add some personal and further recent data about the very complex relations between cognitive impairment and neuropathology in Lewy body diseases. …

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Title: The neuropathologic substrate of Parkinson disease dementia
Author: Kurt A. Jellinger
Publication date: 01-01-2010
Publisher: Springer-Verlag
Published in: Acta Neuropathologica / Issue 1/2010
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-009-0613-1

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