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Acta Neuropathologica
Published in: Acta Neuropathologica 6/2004

01-12-2004 | Regular Paper

Peripheral nerve endoneurial microangiopathy and necrosis in rats with insulinoma

Authors: Kazuhiro Sugimoto, Masaru Shoji, Minoru Yasujima, Toshihiro Suda, Soroku Yagihashi

Published in: Acta Neuropathologica | Issue 6/2004

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Abstract

Peripheral nerve pathology related to chronic hyperinsulinemia and hypoglycemia has yet to be fully explored. Here we conducted a systematic quantitative analysis of morphological alterations in peripheral sensory and motor nerve fibers and endoneurial microvasculature in longstanding insulinoma-carrying rats (I-rats; n=12). Age-matched normal rats (n=6) served as controls. Over the 15-month observation period, two of I-rats developed paresis of the hind limbs when their blood glucose level fell below 1.7 mmol/l. These animals showed a massive myelinated fiber loss associated with active degeneration of residual myelinated fibers and multiple endoneurial microvascular occlusions at the sciatic nerve level. The rest of the non-paretic I-rats showed a decreased density of large myelinated fibers with axonal degeneration in the peroneal nerve and an increased density of small myelinated fibers with preserved morphology in the sural nerve. This was associated with endoneurial microangiopathic changes indicative of endoneurial ischemia/hypoxia in the sciatic and peroneal nerves, and an increase in endoneurial microvascular density in the sciatic and sural nerves. In conjunction with previous data, these findings suggest that the observed increase in endoneurial microvascular density may be a compensatory response to endoneurial ischemia/hypoxia induced by chronic hyperinsulinemia in I-rats without paresis. In conclusion, the present study showed characteristic morphological alterations in peripheral sensory and motor nerve fibers associated with microangiopathy indicative of endoneurial ischemia/hypoxia in the sciatic and peroneal nerves, and provides the first evidence for the occurrence of endoneurial necrosis in the sciatic nerve, to which the hind limb paresis can be ascribed in I-rats.
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Metadata
Title
Peripheral nerve endoneurial microangiopathy and necrosis in rats with insulinoma
Authors
Kazuhiro Sugimoto
Masaru Shoji
Minoru Yasujima
Toshihiro Suda
Soroku Yagihashi
Publication date
01-12-2004
Publisher
Springer-Verlag
Published in
Acta Neuropathologica / Issue 6/2004
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-004-0915-2

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