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01-11-2018 | Review

The role of Wnt signaling in the healing myocardium: a focus on cell specificity

Authors: Ingmar Sören Meyer, Florian Leuschner

Published in: Basic Research in Cardiology | Issue 6/2018

Abstract

Various cell types are involved in the healing process after myocardial infarction (MI). Besides cardiac resident cells (such as cardiomyocytes, fibroblasts and endothelial cells) already present at the lesion site, a massive influx of leukocytes (mainly monocytes and neutrophils) is observed within hours after the ischemic event. So far, little is known about modes of interaction of these cells. Wnt signaling is an evolutionary conserved signaling cassette known to play an important role in cell–cell communication. While the overall reactivation of Wnt signaling upon ischemic injury is well described, the precise expression pattern of Wnt proteins, however, is far from understood. We here describe known Wnt components that partake in MI healing and differentiate cell-specific aspects. The secretion of Wnt proteins and their antagonists in the context of cardiac inflammation after MI appear to be tightly regulated in a spatial–temporal manner. Overall, we aim to stress the importance of elucidating not only Wnt component-specific aspects, but also their sometimes contradicting effects in different target cells. A better understanding of Wnt signaling in MI healing may eventually lead to the development of successful therapeutic approaches in an often considered “un-druggable” pathway.

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Title: The role of Wnt signaling in the healing myocardium: a focus on cell specificity
Authors: Ingmar Sören Meyer
Florian Leuschner
Publication date: 01-11-2018
Publisher: Springer Berlin Heidelberg
Published in: Basic Research in Cardiology / Issue 6/2018
Print ISSN: 0300-8428
Electronic ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-018-0705-y

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