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01-01-2018 | Review

Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases

Authors: Dongling Liu, Xiang Zeng, Xiao Li, Jawahar L. Mehta, Xianwei Wang

Published in: Basic Research in Cardiology | Issue 1/2018

Abstract

NLRP3 inflammasome is a key multiprotein signaling platform that tightly controls inflammatory responses and coordinates antimicrobial host defenses by activating caspase-1 for the subsequent maturation of pro-inflammatory cytokines, IL-1β and IL-18, and induces pyroptosis. The assembly and activation of NLRP3 inflammasome are linked to the pathogenesis of several cardiovascular disease risk factors, such as hypertension and diabetes, and their major consequences—myocardial remodeling. The study of the NLRP3 inflammasome in these cardiovascular disease states may uncover important triggers and endogenous modulators of the disease, and lead to new treatment strategies. This review outlines current insights into NLRP3 inflammasome research associated with cardiovascular diseases and discusses the questions that remain in this field.

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Title: Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases
Authors: Dongling Liu
Xiang Zeng
Xiao Li
Jawahar L. Mehta
Xianwei Wang
Publication date: 01-01-2018
Publisher: Springer Berlin Heidelberg
Published in: Basic Research in Cardiology / Issue 1/2018
Print ISSN: 0300-8428
Electronic ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-017-0663-9

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