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01-09-2015 | Invited Editorial

Hydrogen sulfide and PKG in ischemia–reperfusion injury: sources, signaling, accelerators and brakes

Authors: Ioanna Andreadou, Efstathios K. Iliodromitis, Csaba Szabo, Andreas Papapetropoulos

Published in: Basic Research in Cardiology | Issue 5/2015

Abstract

Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H₂S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dependent protein kinase can lie both downstream and upstream of H₂S. The current literature on this topic is reviewed and data from recent studies are integrated to propose a unifying model.

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Title: Hydrogen sulfide and PKG in ischemia–reperfusion injury: sources, signaling, accelerators and brakes
Authors: Ioanna Andreadou
Efstathios K. Iliodromitis
Csaba Szabo
Andreas Papapetropoulos
Publication date: 01-09-2015
Publisher: Springer Berlin Heidelberg
Published in: Basic Research in Cardiology / Issue 5/2015
Print ISSN: 0300-8428
Electronic ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-015-0510-9

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