Skip to main content
Top
Published in: Basic Research in Cardiology 6/2012

01-11-2012 | Report

Trials, tribulations and speculation! Report from the 7th Biennial Hatter Cardiovascular Institute Workshop

Authors: Robert Bell, Reinier Beeuwkes, Hans Erik Bøtker, Sean Davidson, James Downey, David Garcia-Dorado, Derek J. Hausenloy, Gerd Heusch, Borja Ibanez, Masafumi Kitakaze, Sandrine Lecour, Robert Mentzer, Tetsuji Miura, Lionel Opie, Michel Ovize, Marisol Ruiz-Meana, Rainer Schulz, Richard Shannon, Malcolm Walker, Jakob Vinten-Johansen, Derek Yellon

Published in: Basic Research in Cardiology | Issue 6/2012

Login to get access

Excerpt

The 7th biennial Hatter Cardiovascular Institute Workshop, comprising 21 leading basic science and clinical experts, was held in South Africa in August 2012 to discuss the current cutting edge status of cardioprotection and the application of cardioprotective modalities in the clinical management of myocardial ischaemia/reperfusion injury in the context of acute coronary syndromes and cardiac surgery. The meeting, chaired by Professor Derek Yellon and Professor Lionel Opie, was run to a format of previous Hatter Cardiovascular workshops with data presented by proponents followed by discussion and debate by the faculty. …
Literature
3.
go back to reference Aragon JP, Condit ME, Bhushan S, Predmore BL, Patel SS, Grinsfelder DB, Gundewar S, Jha S, Calvert JW, Barouch LA, Lavu M, Wright HM, Lefer DJ (2011) Beta3-adrenoreceptor stimulation ameliorates myocardial ischemia-reperfusion injury via endothelial nitric oxide synthase and neuronal nitric oxide synthase activation. J Am Coll Cardiol 58:2683–2691. doi:10.1016/j.jacc.2011.09.033 PubMedCrossRef Aragon JP, Condit ME, Bhushan S, Predmore BL, Patel SS, Grinsfelder DB, Gundewar S, Jha S, Calvert JW, Barouch LA, Lavu M, Wright HM, Lefer DJ (2011) Beta3-adrenoreceptor stimulation ameliorates myocardial ischemia-reperfusion injury via endothelial nitric oxide synthase and neuronal nitric oxide synthase activation. J Am Coll Cardiol 58:2683–2691. doi:10.​1016/​j.​jacc.​2011.​09.​033 PubMedCrossRef
4.
go back to reference Azarashvili T, Baburina Y, Grachev D, Krestinina O, Evtodienko Y, Stricker R, Reiser G (2011) Calcium-induced permeability transition in rat brain mitochondria is promoted by carbenoxolone through targeting connexin43. Am J Physiol Cell Physiol 300:C707–C720. doi:10.1152/ajpcell.00061.2010 PubMedCrossRef Azarashvili T, Baburina Y, Grachev D, Krestinina O, Evtodienko Y, Stricker R, Reiser G (2011) Calcium-induced permeability transition in rat brain mitochondria is promoted by carbenoxolone through targeting connexin43. Am J Physiol Cell Physiol 300:C707–C720. doi:10.​1152/​ajpcell.​00061.​2010 PubMedCrossRef
5.
go back to reference Basalay M, Barsukevich V, Mastitskaya S, Mrochek A, Pernow J, Sjoquist PO, Ackland GL, Gourine AV, Gourine A (2012) Remote ischaemic pre- and delayed postconditioning—similar degree of cardioprotection but distinct mechanisms. Exp Physiol 97:908–917. doi:10.1113/expphysiol.2012.064923 PubMedCrossRef Basalay M, Barsukevich V, Mastitskaya S, Mrochek A, Pernow J, Sjoquist PO, Ackland GL, Gourine AV, Gourine A (2012) Remote ischaemic pre- and delayed postconditioning—similar degree of cardioprotection but distinct mechanisms. Exp Physiol 97:908–917. doi:10.​1113/​expphysiol.​2012.​064923 PubMedCrossRef
6.
go back to reference Boengler K, Dodoni G, Rodriguez-Sinovas A, Cabestrero A, Ruiz-Meana M, Gres P, Konietzka I, Lopez-Iglesias C, Garcia-Dorado D, Di Lisa F, Heusch G, Schulz R (2005) Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning. Cardiovasc Res 67:234–244. doi:10.1016/j.cardiores.2005.04.014 PubMedCrossRef Boengler K, Dodoni G, Rodriguez-Sinovas A, Cabestrero A, Ruiz-Meana M, Gres P, Konietzka I, Lopez-Iglesias C, Garcia-Dorado D, Di Lisa F, Heusch G, Schulz R (2005) Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning. Cardiovasc Res 67:234–244. doi:10.​1016/​j.​cardiores.​2005.​04.​014 PubMedCrossRef
7.
go back to reference Boengler K, Ruiz-Meana M, Gent S, Ungefug E, Soetkamp D, Miro-Casas E, Cabestrero A, Fernandez-Sanz C, Semenzato M, Lisa FD, Rohrbach S, Garcia-Dorado D, Heusch G, Schulz R, Mercola M (2012) Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption. J Cell Mol Med 16:1649–1655. doi:10.1111/j.1582-4934.2011.01516.x PubMedCrossRef Boengler K, Ruiz-Meana M, Gent S, Ungefug E, Soetkamp D, Miro-Casas E, Cabestrero A, Fernandez-Sanz C, Semenzato M, Lisa FD, Rohrbach S, Garcia-Dorado D, Heusch G, Schulz R, Mercola M (2012) Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption. J Cell Mol Med 16:1649–1655. doi:10.​1111/​j.​1582-4934.​2011.​01516.​x PubMedCrossRef
9.
go back to reference Boengler K, Stahlhofen S, van de Sand A, Gres P, Ruiz-Meana M, Garcia-Dorado D, Heusch G, Schulz R (2009) Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria. Basic Res Cardiol 104:141–147. doi:10.1007/s00395-009-0007-5 PubMedCrossRef Boengler K, Stahlhofen S, van de Sand A, Gres P, Ruiz-Meana M, Garcia-Dorado D, Heusch G, Schulz R (2009) Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria. Basic Res Cardiol 104:141–147. doi:10.​1007/​s00395-009-0007-5 PubMedCrossRef
11.
go back to reference Grossman AN, Opie LH, Beshansky JR, Rackley CE, Ingwall SS, Selker HP (2012) Glucose-insulin-potassium revived: current status in acute coronary syndromes and the failing heart. Circulation (in press) Grossman AN, Opie LH, Beshansky JR, Rackley CE, Ingwall SS, Selker HP (2012) Glucose-insulin-potassium revived: current status in acute coronary syndromes and the failing heart. Circulation (in press)
12.
go back to reference Hearse DJ, Yellon DM, Downey JM (1986) Can beta blockers limit myocardial infarct size? Eur Heart J 7:925–930PubMed Hearse DJ, Yellon DM, Downey JM (1986) Can beta blockers limit myocardial infarct size? Eur Heart J 7:925–930PubMed
13.
15.
go back to reference Heusch G (2012) Cardioprotection—chances and challenges of its translation to the clinic. Lancet (in press) Heusch G (2012) Cardioprotection—chances and challenges of its translation to the clinic. Lancet (in press)
18.
19.
go back to reference Ibanez B, Cimmino G, Prat-Gonzalez S, Vilahur G, Hutter R, Garcia MJ, Fuster V, Sanz J, Badimon L, Badimon JJ (2011) The cardioprotection granted by metoprolol is restricted to its administration prior to coronary reperfusion. Int J Cardiol 147:428–432. doi:10.1016/j.ijcard.2009.09.551 PubMedCrossRef Ibanez B, Cimmino G, Prat-Gonzalez S, Vilahur G, Hutter R, Garcia MJ, Fuster V, Sanz J, Badimon L, Badimon JJ (2011) The cardioprotection granted by metoprolol is restricted to its administration prior to coronary reperfusion. Int J Cardiol 147:428–432. doi:10.​1016/​j.​ijcard.​2009.​09.​551 PubMedCrossRef
20.
21.
go back to reference Miro-Casas E, Ruiz-Meana M, Agullo E, Stahlhofen S, Rodriguez-Sinovas A, Cabestrero A, Jorge I, Torre I, Vazquez J, Boengler K, Schulz R, Heusch G, Garcia-Dorado D (2009) Connexin43 in cardiomyocyte mitochondria contributes to mitochondrial potassium uptake. Cardiovasc Res 83:747–756. doi:10.1093/cvr/cvp157 PubMedCrossRef Miro-Casas E, Ruiz-Meana M, Agullo E, Stahlhofen S, Rodriguez-Sinovas A, Cabestrero A, Jorge I, Torre I, Vazquez J, Boengler K, Schulz R, Heusch G, Garcia-Dorado D (2009) Connexin43 in cardiomyocyte mitochondria contributes to mitochondrial potassium uptake. Cardiovasc Res 83:747–756. doi:10.​1093/​cvr/​cvp157 PubMedCrossRef
22.
go back to reference Musiolik J, van Caster P, Skyschally A, Boengler K, Gres P, Schulz R, Heusch G (2010) Reduction of infarct size by gentle reperfusion without activation of reperfusion injury salvage kinases in pigs. Cardiovasc Res 85:110–117. doi:10.1093/cvr/cvp271 PubMedCrossRef Musiolik J, van Caster P, Skyschally A, Boengler K, Gres P, Schulz R, Heusch G (2010) Reduction of infarct size by gentle reperfusion without activation of reperfusion injury salvage kinases in pigs. Cardiovasc Res 85:110–117. doi:10.​1093/​cvr/​cvp271 PubMedCrossRef
26.
go back to reference Rodriguez-Sinovas A, Boengler K, Cabestrero A, Gres P, Morente M, Ruiz-Meana M, Konietzka I, Miro E, Totzeck A, Heusch G, Schulz R, Garcia-Dorado D (2006) Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotection. Circ Res 99:93–101. doi:10.1161/01.RES.0000230315.56904.de PubMedCrossRef Rodriguez-Sinovas A, Boengler K, Cabestrero A, Gres P, Morente M, Ruiz-Meana M, Konietzka I, Miro E, Totzeck A, Heusch G, Schulz R, Garcia-Dorado D (2006) Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotection. Circ Res 99:93–101. doi:10.​1161/​01.​RES.​0000230315.​56904.​de PubMedCrossRef
27.
go back to reference Rottlaender D, Boengler K, Wolny M, Michels G, Endres-Becker J, Motloch LJ, Schwaiger A, Buechert A, Schulz R, Heusch G, Hoppe UC (2010) Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial KATP channels in mouse cardiomyocytes. J Clin Invest 120:1441–1453. doi:10.1172/JCI40927 PubMedCrossRef Rottlaender D, Boengler K, Wolny M, Michels G, Endres-Becker J, Motloch LJ, Schwaiger A, Buechert A, Schulz R, Heusch G, Hoppe UC (2010) Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial KATP channels in mouse cardiomyocytes. J Clin Invest 120:1441–1453. doi:10.​1172/​JCI40927 PubMedCrossRef
28.
go back to reference Rottlaender D, Boengler K, Wolny M, Schwaiger A, Motloch LJ, Ovize M, Schulz R, Heusch G, Hoppe UC (2012) Glycogen synthase kinase 3beta transfers cytoprotective signaling through connexin 43 onto mitochondrial ATP-sensitive K+ channels. Proc Nat Acad Sci USA 109:E242–E251. doi:10.1073/pnas.1107479109 PubMedCrossRef Rottlaender D, Boengler K, Wolny M, Schwaiger A, Motloch LJ, Ovize M, Schulz R, Heusch G, Hoppe UC (2012) Glycogen synthase kinase 3beta transfers cytoprotective signaling through connexin 43 onto mitochondrial ATP-sensitive K+ channels. Proc Nat Acad Sci USA 109:E242–E251. doi:10.​1073/​pnas.​1107479109 PubMedCrossRef
29.
go back to reference Roubille F, Franck-Miclo A, Covinhes A, Lafont C, Cransac F, Combes S, Vincent A, Fontanaud P, Sportouch-Dukhan C, Redt-Clouet C, Nargeot J, Piot C, Barrere-Lemaire S (2011) Delayed postconditioning in the mouse heart in vivo. Circulation 124:1330–1336. doi:10.1161/CIRCULATIONAHA.111.031864 PubMedCrossRef Roubille F, Franck-Miclo A, Covinhes A, Lafont C, Cransac F, Combes S, Vincent A, Fontanaud P, Sportouch-Dukhan C, Redt-Clouet C, Nargeot J, Piot C, Barrere-Lemaire S (2011) Delayed postconditioning in the mouse heart in vivo. Circulation 124:1330–1336. doi:10.​1161/​CIRCULATIONAHA.​111.​031864 PubMedCrossRef
30.
go back to reference Roubille F, Lairez O, Mewton N, Rioufol G, Ranc S, Sanchez I, Cung TT, Elbaz M, Piot C, Ovize M (2012) Cardioprotection by clopidogrel in acute ST-elevated myocardial infarction patients: a retrospective analysis. Basic Res Cardiol 107:275. doi:10.1007/s00395-012-0275-3 PubMedCrossRef Roubille F, Lairez O, Mewton N, Rioufol G, Ranc S, Sanchez I, Cung TT, Elbaz M, Piot C, Ovize M (2012) Cardioprotection by clopidogrel in acute ST-elevated myocardial infarction patients: a retrospective analysis. Basic Res Cardiol 107:275. doi:10.​1007/​s00395-012-0275-3 PubMedCrossRef
31.
go back to reference Sawicki G, Leon H, Sawicka J, Sariahmetoglu M, Schulze CJ, Scott PG, Szczesna-Cordary D, Schulz R (2005) Degradation of myosin light chain in isolated rat hearts subjected to ischemia-reperfusion injury: a new intracellular target for matrix metalloproteinase-2. Circulation 112:544–552. doi:10.1161/CIRCULATIONAHA.104.531616 PubMedCrossRef Sawicki G, Leon H, Sawicka J, Sariahmetoglu M, Schulze CJ, Scott PG, Szczesna-Cordary D, Schulz R (2005) Degradation of myosin light chain in isolated rat hearts subjected to ischemia-reperfusion injury: a new intracellular target for matrix metalloproteinase-2. Circulation 112:544–552. doi:10.​1161/​CIRCULATIONAHA.​104.​531616 PubMedCrossRef
32.
go back to reference Selker HP, Beshansky JR, Sheehan PR, Massaro JM, Griffith JL, D’Agostino RB, Ruthazer R, Atkins JM, Sayah AJ, Levy MK, Richards ME, Aufderheide TP, Braude DA, Pirrallo RG, Doyle DD, Frascone RJ, Kosiak DJ, Leaming JM, Van Gelder CM, Walter GP, Wayne MA, Woolard RH, Opie LH, Rackley CE, Apstein CS, Udelson JE (2012) Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trial. JAMA 307:1925–1933. doi:10.1001/jama.2012.426 PubMedCrossRef Selker HP, Beshansky JR, Sheehan PR, Massaro JM, Griffith JL, D’Agostino RB, Ruthazer R, Atkins JM, Sayah AJ, Levy MK, Richards ME, Aufderheide TP, Braude DA, Pirrallo RG, Doyle DD, Frascone RJ, Kosiak DJ, Leaming JM, Van Gelder CM, Walter GP, Wayne MA, Woolard RH, Opie LH, Rackley CE, Apstein CS, Udelson JE (2012) Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trial. JAMA 307:1925–1933. doi:10.​1001/​jama.​2012.​426 PubMedCrossRef
33.
go back to reference Sodi-Pallares D, Testelli MR, Fishleder BL, Bisteni A, Medrano GA, Friedland C, De Micheli A (1962) Effects of an intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction. A preliminary clinical report. Am J Cardiol 9:166–181PubMedCrossRef Sodi-Pallares D, Testelli MR, Fishleder BL, Bisteni A, Medrano GA, Friedland C, De Micheli A (1962) Effects of an intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction. A preliminary clinical report. Am J Cardiol 9:166–181PubMedCrossRef
34.
36.
Metadata
Title
Trials, tribulations and speculation! Report from the 7th Biennial Hatter Cardiovascular Institute Workshop
Authors
Robert Bell
Reinier Beeuwkes
Hans Erik Bøtker
Sean Davidson
James Downey
David Garcia-Dorado
Derek J. Hausenloy
Gerd Heusch
Borja Ibanez
Masafumi Kitakaze
Sandrine Lecour
Robert Mentzer
Tetsuji Miura
Lionel Opie
Michel Ovize
Marisol Ruiz-Meana
Rainer Schulz
Richard Shannon
Malcolm Walker
Jakob Vinten-Johansen
Derek Yellon
Publication date
01-11-2012
Publisher
Springer-Verlag
Published in
Basic Research in Cardiology / Issue 6/2012
Print ISSN: 0300-8428
Electronic ISSN: 1435-1803
DOI
https://doi.org/10.1007/s00395-012-0300-6

Other articles of this Issue 6/2012

Basic Research in Cardiology 6/2012 Go to the issue