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Open Access 01-09-2011 | Invited Review

NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies

Authors: Alexander Sirker, Min Zhang, Ajay M. Shah

Published in: Basic Research in Cardiology | Issue 5/2011

Abstract

NADPH oxidase family enzymes (or NOXs) are the major sources of reactive oxygen species (ROS) that are implicated in the pathophysiology of many cardiovascular diseases. These enzymes appear to be especially important in the modulation of redox-sensitive signalling pathways that underlie key cellular functions such as growth, differentiation, migration and proliferation. Seven distinct members of the family have been identified of which four (namely NOX1, 2, 4 and 5) may have cardiovascular functions. In this article, we review our current understanding of the roles of NOX enzymes in several common cardiovascular disease states, with a focus on data from genetic studies and clinical data where available.

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Title: NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies
Authors: Alexander Sirker
Min Zhang
Ajay M. Shah
Publication date: 01-09-2011
Publisher: Springer-Verlag
Published in: Basic Research in Cardiology / Issue 5/2011
Print ISSN: 0300-8428
Electronic ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-011-0190-z

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