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01-07-2010 | Review

Hepatocyte growth factor/Met gene transfer in cardiac stem cells—potential for cardiac repair

Authors: Rosalinda Madonna, Gregg Rokosh, Raffaele De Caterina, Roberto Bolli

Published in: Basic Research in Cardiology | Issue 4/2010

Abstract

The adult heart has been recently recognized as a self-renewing organ that contains a pool of committed resident cardiac stem cells (CSCs) and cardiac progenitor cells (CPCs). These adult CSCs and CPCs can be induced by cytokines and growth factors to migrate, differentiate, and proliferate in situ and potentially replace lost cardiomyocytes. Ligand-receptor systems, such as the tyrosine kinase receptor mesenchymal–epithelial transition factor (Met) and its ligand hepatocyte growth factor (HGF), are potential candidates for boosting migration, engraftment and commitment of CSCs. Here, we discuss the possible application of HGF/Met gene therapy to enhance the ability of CSCs to promote myocardial regeneration.

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Title: Hepatocyte growth factor/Met gene transfer in cardiac stem cells—potential for cardiac repair
Authors: Rosalinda Madonna
Gregg Rokosh
Raffaele De Caterina
Roberto Bolli
Publication date: 01-07-2010
Publisher: Springer-Verlag
Published in: Basic Research in Cardiology / Issue 4/2010
Print ISSN: 0300-8428
Electronic ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-010-0102-7

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