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Published in: European Journal of Nutrition 2/2019

Open Access 01-11-2019 | Respiratory Microbiota | Review

Future prospects for dissecting inter-individual variability in the absorption, distribution and elimination of plant bioactives of relevance for cardiometabolic endpoints

Authors: Rikard Landberg, Claudine Manach, Frederiek-Maarten Kerckhof, Anne-Marie Minihane, Rasha Noureldin M. Saleh, Baukje De Roos, Francisco Tomas-Barberan, Christine Morand, Tom Van de Wiele

Published in: European Journal of Nutrition | Special Issue 2/2019

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Abstract

Purpose

The health-promoting potential of food-derived plant bioactive compounds is evident but not always consistent across studies. Large inter-individual variability may originate from differences in digestion, absorption, distribution, metabolism and excretion (ADME). ADME can be modulated by age, sex, dietary habits, microbiome composition, genetic variation, drug exposure and many other factors. Within the recent COST Action POSITIVe, large-scale literature surveys were undertaken to identify the reasons and extent of inter-individual variability in ADME of selected plant bioactive compounds of importance to cardiometabolic health. The aim of the present review is to summarize the findings and suggest a framework for future studies designed to investigate the etiology of inter-individual variability in plant bioactive ADME and bioefficacy.

Results

Few studies have reported individual data on the ADME of bioactive compounds and on determinants such as age, diet, lifestyle, health status and medication, thereby limiting a mechanistic understanding of the main drivers of variation in ADME processes observed across individuals. Metabolomics represent crucial techniques to decipher inter-individual variability and to stratify individuals according to metabotypes reflecting the intrinsic capacity to absorb and metabolize bioactive compounds.

Conclusion

A methodological framework was developed to decipher how the contribution from genetic variants or microbiome variants to ADME of bioactive compounds can be predicted. Future study design should include (1) a larger number of study participants, (2) individual and full profiling of all possible determinants of internal exposure, (3) the presentation of individual ADME data and (4) incorporation of omics platforms, such as genomics, microbiomics and metabolomics in ADME and efficacy studies.
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Metadata
Title
Future prospects for dissecting inter-individual variability in the absorption, distribution and elimination of plant bioactives of relevance for cardiometabolic endpoints
Authors
Rikard Landberg
Claudine Manach
Frederiek-Maarten Kerckhof
Anne-Marie Minihane
Rasha Noureldin M. Saleh
Baukje De Roos
Francisco Tomas-Barberan
Christine Morand
Tom Van de Wiele
Publication date
01-11-2019
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nutrition / Issue Special Issue 2/2019
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-019-02095-1

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