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01-04-2020 | Original Contribution

Mediterranean diet, physical activity and subcutaneous advanced glycation end-products’ accumulation: a cross-sectional analysis in the ILERVAS project

Authors: Enric Sánchez, Àngels Betriu, Jordi Salas-Salvadó, Reinald Pamplona, Ferrán Barbé, Francesc Purroy, Cristina Farràs, Elvira Fernández, Carolina López-Cano, Chadia Mizab, Albert Lecube, the ILERVAS project investigators

Published in: European Journal of Nutrition | Issue 3/2020

Abstract

Purpose

Adherence to Mediterranean diet (MedDiet) and physical activity have been associated to lower cardiovascular risk and mortality. Our purpose was to test the modification of advanced glycation end-products (AGEs) as one of the underlying mechanisms explaining this relationship.

Methods

Cross-sectional study assessing the adherence to MedDiet (14-item Mediterranean Diet Adherence Screener) and physical activity (International Physical Activity Questionnaire short form) in 2646 middle-aged subjects without known cardiovascular disease and type 2 diabetes from the ILERVAS study. Skin autofluorescence (SAF), a non-invasive assessment of subcutaneous AGEs, was measured. Multivariable logistic regression models were done to study interactions and independent associations with a likelihood ratio test.

Results

Participants with a high adherence to MedDiet had lower SAF than those with low adherence (1.8 [IR 1.6; 2.1] vs. 2.0 [IR 1.7; 2.3] arbitrary units, p < 0.001), without differences according to categories of physical activity. There was an independent association between high adherence to MedDiet and the SAF values [OR 0.59 (0.37–0.94), p = 0.026]. When adherence to MedDiet was substituted by its individual food components, high intake of vegetables, fruits and nuts, and low intake of sugar-sweetened soft beverages were independently associated with a decreased SAF (p ≤ 0.045). No interaction between MedDiet and physical activity on SAF values was observed except for nuts consumption (p = 0.047).

Conclusions

Adherence to the MedDiet, but not physical activity, was negatively associated to SAF measurements. This association can be explained by some typical food components of the MedDiet. The present study offers a better understanding of the plausible biological conditions underlying the prevention of cardiovascular disease with MedDiet.

ClinTrials.gov identifier: NCT03228459.

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Title: Mediterranean diet, physical activity and subcutaneous advanced glycation end-products’ accumulation: a cross-sectional analysis in the ILERVAS project
Authors: Enric Sánchez
Àngels Betriu
Jordi Salas-Salvadó
Reinald Pamplona
Ferrán Barbé
Francesc Purroy
Cristina Farràs
Elvira Fernández
Carolina López-Cano
Chadia Mizab
Albert Lecube
the ILERVAS project investigators
Publication date: 01-04-2020
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 3/2020
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-019-01983-w

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Purpose

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Results

Conclusions

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