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01-08-2019 | Original Contribution

Median urinary iodine concentration reflected sufficient iodine supply in neonates from Northeast Germany in 2005–2006

Authors: Till Ittermann, Henry Völzke, Anne Krey, Thomas Remer, Matthias Heckmann, Anja Lange, Axel Kramer, Harald Below

Published in: European Journal of Nutrition | Issue 5/2019

Abstract

Purpose

Data from recent adult studies suggest a decline of median urinary iodine concentrations (UIC) in Germany, but since 1996 no German study investigated UIC in neonates. The aim of our study was to investigate UIC and serum thyroid-stimulating hormone (TSH) levels in neonates from Germany.

Methods

We used data from 399 neonates, which were born between April 2005 and November 2006 in the Northeast of Germany. UIC were evaluated by a photometric procedure with Sandell and Kolthoff reaction and afterwards corrected to be comparable with an ICP-MS method. TSH was determined from capillary blood, which was taken within 5 days after birth, by DELFIA.

Results

Median UIC were 150 µg/L (25th percentile: 104 µg/L; 75th percentile: 196 µg/L) and differed between boys (153.3 µg/L) and girls (131.5 µg/L; p = 0.012). The prevalence of serum TSH levels > 5 mIU/L was 14%. Neonates from mothers with intake of iodine supplementation (150 µg/L) had significantly higher median UIC than neonates from mothers without iodine supplementation (132 µg/L; p = 0.011). Multivariable linear regression adjusted for sex and iodine supplementation of the mother revealed a significant association between UIC and log-transformed serum TSH levels (β = 0.003: 95% confidence interval (CI) = 0.0001–0.005; p = 0.028).

Conclusions

Neonates in Northeast Germany did show a sufficient supply of iodine. This points towards the possibility of a sufficient iodine supply of neonates also in other regions of Germany, even though recent studies in adults may indicate mild iodine deficiency.

Meng W, Scriba P (2002) Jodversorgung in Deutschland, Probleme und erforderliche Maßnahmen: update 2002 [Iodine supply in Germany, problems and required measures: update 2002]. Dtsch Ärztebl 99:A2560–A2564

Remer T, Fonteyn N, Alexy U, Berkemeyer S (2006) Longitudinal examination of 24-h urinary iodine excretion in schoolchildren as a sensitive, hydration status-independent research tool for studying iodine status. Am J Clin Nutr 83:639–646. https://doi.org/10.1093/ajcn.83.3.639 CrossRefPubMed

Johner SA, Gunther AL, Remer T (2011) Current trends of 24-h urinary iodine excretion in German schoolchildren and the importance of iodised salt in processed foods. Br J Nutr 106:1749–1756. https://doi.org/10.1017/S0007114511005502 CrossRefPubMed

Hampel R, Bennohr G, Gordalla A, Below H (2009) Urinary iodine excretion in German adults in 2005 meets WHO target. Med Klin (Munich) 104:425–428. https://doi.org/10.1007/s00063-009-1090-y CrossRef

Khattak RM, Ittermann T, Nauck M, Below H, Volzke H (2016) Monitoring the prevalence of thyroid disorders in the adult population of Northeast Germany. Popul Health Metr 14:39. https://doi.org/10.1186/s12963-016-0111-3 CrossRefPubMedPubMedCentral

Meisinger C, Ittermann T, Wallaschofski H, Heier M, Below H, Kramer A, Doring A, Nauck M, Volzke H (2012) Geographic variations in the frequency of thyroid disorders and thyroid peroxidase antibodies in persons without former thyroid disease within Germany. Eur J Endocrinol 167:363–371. https://doi.org/10.1530/EJE-12-0111 CrossRefPubMed

Volzke H, Ittermann T, Albers M, Friedrich N, Nauck M, Below H, Kramer A (2012) Five-year change in morphological and functional alterations of the thyroid gland: the Study of Health in Pomerania. Thyroid 22:737–746. https://doi.org/10.1089/thy.2011.0525 CrossRefPubMed

Thamm M, Ellert U, Thierfelder W, Liesenkotter KP, Volzke H (2007) Iodine intake in Germany. Results of iodine monitoring in the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 50:744–749. https://doi.org/10.1007/s00103-007-0236-4 CrossRefPubMed

Johner SA, Thamm M, Schmitz R, Remer T (2016) Examination of iodine status in the German population: an example for methodological pitfalls of the current approach of iodine status assessment. Eur J Nutr 55:1275–1282. https://doi.org/10.1007/s00394-015-0941-y CrossRefPubMed

10.

Manz F, Bohmer T, Gartner R, Grossklaus R, Klett M, Schneider R (2002) Quantification of iodine supply: representative data on intake and urinary excretion of iodine from the German population in 1996. Ann Nutr Metab 46:128–138. https://doi.org/10.1159/000063083 CrossRefPubMed

11.

World Health Organization (2007) Assessment of iodine deficiency disorders and monitoring their elimination. A guide for programme managers, 3rd edn, WHO

12.

Lange AE, Lange J, Ittermann T, Napp M, Krueger PC, Bahlmann H, Kasch R, Heckmann M (2017) Population-based study of the incidence of congenital hip dysplasia in preterm infants from the Survey of Neonates in Pomerania (SNiP). BMC Pediatr 17:78. https://doi.org/10.1186/s12887-017-0829-5 CrossRefPubMedPubMedCentral

13.

Volzke H, Alte D, Schmidt CO, Radke D, Lorbeer R, Friedrich N, Aumann N, Lau K, Piontek M, Born G, Havemann C, Ittermann T, Schipf S, Haring R, Baumeister SE, Wallaschofski H, Nauck M, Frick S, Arnold A, Junger M, Mayerle J, Kraft M, Lerch MM, Dorr M, Reffelmann T, Empen K, Felix SB, Obst A, Koch B, Glaser S, Ewert R, Fietze I, Penzel T, Doren M, Rathmann W, Haerting J, Hannemann M, Ropcke J, Schminke U, Jurgens C, Tost F, Rettig R, Kors JA, Ungerer S, Hegenscheid K, Kuhn JP, Kuhn J, Hosten N, Puls R, Henke J, Gloger O, Teumer A, Homuth G, Volker U, Schwahn C, Holtfreter B, Polzer I, Kohlmann T, Grabe HJ, Rosskopf D, Kroemer HK, Kocher T, Biffar R, John U, Hoffmann W (2011) Cohort profile: the study of health in Pomerania. Int J Epidemiol 40:294–307. https://doi.org/10.1093/ije/dyp394 CrossRefPubMed

14.

Lorenz-Wawschinek O, Tiran B, Eber O, Langsteger W (1994) Photometric determination of iodine in urine. Exp Clin Endocrinol 102:57–58

15.

Ittermann T, Johner S, Below H, Leiterer M, Thamm M, Remer T, Volzke H (2017) Interlaboratory variability of urinary iodine measurements. Clin Chem Lab Med. https://doi.org/10.1515/cclm-2017-0580 CrossRef

16.

Gónzalez-Iglesias H, de la Flor St Remy RR, López-Sastre J, Fernández-Colomer B, Ibáñez-Fernández A, Solis G, Sanz-Medel A, Fernández-Sánchez ML (2012) Efficiency of iodine supplementation, as potassium iodide, during lactation: a study in neonates and their mothers. Food Chem 133:859–865CrossRef

17.

Volzke H, Caron P, Dahl L, de Castro JJ, Erlund I, Gaberscek S, Gunnarsdottir I, Hubalewska-Dydejczyk A, Ittermann T, Ivanova L, Karanfilski B, Khattak RM, Kusic Z, Laurberg P, Lazarus JH, Markou KB, Moreno-Reyes R, Nagy EV, Peeters RP, Pirags V, Podoba J, Rayman MP, Rochau U, Siebert U, Smyth PP, Thuesen BH, Troen A, Vila L, Vitti P, Zamrazil V, Zimmermann MB (2016) Ensuring effective prevention of iodine deficiency disorders. Thyroid 26:189–196. https://doi.org/10.1089/thy.2015.0543 CrossRefPubMed

18.

Shelor CP, Dasgupta PK (2011) Review of analytical methods for the quantification of iodine in complex matrices. Anal Chim Acta 702:16–36. https://doi.org/10.1016/j.aca.2011.05.039 CrossRefPubMed

19.

Bundesinstitut für Risikobewertung (2014) Jod, Folat/Folsäure und Schwangerschaft. BFR, Berlin

20.

Forest MG, Sizonenko PC, Cathiard AM, Bertrand J (1974) Hypophyso-gonadal function in humans during the first year of life. 1. Evidence for testicular activity in early infancy. J Clin Invest 53:819–828. https://doi.org/10.1172/JCI107621 CrossRefPubMedPubMedCentral

21.

Rees J, Shuster S (1981) Pubertal induction of sweat gland activity. Clin Sci (Lond) 60:689–692CrossRef

22.

Gordon JH, Leung AM, Hale AR, Pearce EN, Braverman LE, He X, Belfort MB, Nelson SM, Brown RS (2014) No difference in urinary iodine concentrations between Boston-area breastfed and formula-fed infants. Thyroid 24:1309–1313. https://doi.org/10.1089/thy.2014.0026 CrossRefPubMedPubMedCentral

23.

Nazeri P, Dalili H, Mehrabi Y, Hedayati M, Mirmiran P, Azizi F (2018) Is there any difference between the iodine statuses of breast-fed and formula-fed infants and their mothers in an area with iodine sufficiency? Br J Nutr. https://doi.org/10.1017/S0007114518000351 CrossRefPubMed

24.

Henjum S, Lilleengen AM, Aakre I, Dudareva A, Gjengedal ELF, Meltzer HM, Brantsaeter AL (2017) Suboptimal iodine concentration in breastmilk and inadequate iodine intake among lactating women in Norway. Nutrients. https://doi.org/10.3390/nu9070643 CrossRefPubMedPubMedCentral

25.

Andersen SL, Sorensen LK, Krejbjerg A, Moller M, Klitbo DM, Nohr SB, Pedersen KM, Laurberg P (2015) Iodine status in Danish pregnant and breastfeeding women including studies of some challenges in urinary iodine status evaluation. J Trace Elem Med Biol 31:285–289. https://doi.org/10.1016/j.jtemb.2014.11.004 CrossRefPubMed

26.

Delange F, Bourdoux P, Ermans A (1985) Transient disorders of thyroid function and regulation in preterm infants In: Delange F, Fisher P, Malvaux P (eds) Pediatric thyroidology. Karger, Basel, pp 369–393

27.

Johner SA, Thamm M, Stehle P, Nothlings U, Kriener E, Volzke H, Gartner R, Remer T (2014) Interrelations between thyrotropin levels and iodine status in thyroid-healthy children. Thyroid 24:1071–1079. https://doi.org/10.1089/thy.2013.0480 CrossRefPubMedPubMedCentral

28.

Ittermann T, Khattak RM, Nauck M, Cordova CM, Volzke H (2015) Shift of the TSH reference range with improved iodine supply in Northeast Germany. Eur J Endocrinol 172:261–267. https://doi.org/10.1530/EJE-14-0898 CrossRefPubMed

29.

Sack J, Fisher DA, Wang CC (1976) Serum thyrotropin, prolactin, and growth hormone levels during the early neonatal period in the human infant. J Pediatr 89:298–300CrossRefPubMed

Title: Median urinary iodine concentration reflected sufficient iodine supply in neonates from Northeast Germany in 2005–2006
Authors: Till Ittermann
Henry Völzke
Anne Krey
Thomas Remer
Matthias Heckmann
Anja Lange
Axel Kramer
Harald Below
Publication date: 01-08-2019
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 5/2019
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-018-1731-0

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