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01-06-2019 | Original Contribution

Vitamin B₂ intake reduces the risk for colorectal cancer: a dose–response analysis

Authors: Shuai Ben, Mulong Du, Gaoxiang Ma, Jianhua Qu, Liyang Zhu, Haiyan Chu, Zhengdong Zhang, Yuan Wu, Dongying Gu, Meilin Wang

Published in: European Journal of Nutrition | Issue 4/2019

Abstract

Purpose

Several epidemiological studies have assessed the ability of vitamin B₂ to prevent colorectal cancer (CRC), but the results are controversial results. We conducted a dose–response meta-analysis to investigate the association between vitamin B₂ and CRC risk.

Methods

We searched the PubMed and EMBASE database until January 3, 2018 to identify relevant studies. The pooled relative risks (RRs) with the corresponding 95% confidence intervals (CIs) were calculated using a random-effects model or fixed-effects model. The dose–response relationship was assessed by restricted cubic splines.

Results

A total of 14 studies reporting vitamin B₂ intake and two studies reporting blood vitamin B₂ concentration, comprising 14,934 cases and 1593 cases, respectively, were included in the meta-analysis. Vitamin B₂ intake was inversely associated with CRC risk (RR = 0.87; 95% CI 0.81–0.93). Similar results were found for total vitamin B₂ intake from diet and supplements (RR = 0.86; 95% CI 0.78–0.94) and dietary vitamin B₂ intake (RR = 0.89, 95% CI 0.82–0.98) in subgroup analyses. The dose–response model indicated a non-linear trend, and CRC risk was reduced by 10% when vitamin B₂ intake increased to 5 mg/day. In addition, high blood concentrations of vitamin B₂ could also reduce the CRC risk (RR = 0.74; 95% CI 0.59–0.92).

Conclusions

This dose–response analysis indicates that vitamin B₂ intake is inversely associated with CRC risk. The inverse association may also exist between blood vitamin B₂ concentration and CRC risk. These results suggest the importance of vitamin B₂ intake in the prevention of CRC.

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Title: Vitamin B2 intake reduces the risk for colorectal cancer: a dose–response analysis
Authors: Shuai Ben
Mulong Du
Gaoxiang Ma
Jianhua Qu
Liyang Zhu
Haiyan Chu
Zhengdong Zhang
Yuan Wu
Dongying Gu
Meilin Wang
Publication date: 01-06-2019
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 4/2019
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-018-1702-5

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