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01-06-2019 | Original Contribution

A circadian rhythm-related MTNR1B genetic variant modulates the effect of weight-loss diets on changes in adiposity and body composition: the POUNDS Lost trial

Authors: Leticia Goni, Dianjianyi Sun, Yoriko Heianza, Tiange Wang, Tao Huang, J. Alfredo Martínez, Xiaoyun Shang, George A. Bray, Steven R. Smith, Frank M. Sacks, Lu Qi

Published in: European Journal of Nutrition | Issue 4/2019

Abstract

Purpose

A common variant of the melatonin receptor 1B (MTNR1B) gene has been related to increased signaling of melatonin, a hormone previously associated with body fatness mainly through effects on energy metabolism. We examined whether the MTNR1B variant affects changes of body fatness and composition in response to a dietary weight loss intervention.

Methods

The MTNR1B rs10830963 variant was genotyped for 722 overweight and obese individuals, who were randomly assigned to one of four diets varying in macronutrient composition. Anthropometric and body composition measurements (DXA scan) were collected at baseline and at 6 and 24 months of follow-up.

Results

Statistically significant interactions were observed between the MTNR1B genotype and low-/high-fat diet on changes in weight, body mass index (BMI), waist circumference (WC) and total body fat (p interaction = 0.01, 0.02, 0.002 and 0.04, respectively), at 6 months of dietary intervention. In the low-fat diet group, increasing number of the sleep disruption-related G allele was significantly associated with a decrease in weight (p = 0.004), BMI (p = 0.005) and WC (p = 0.001). In the high-fat diet group, carrying the G allele was positively associated with changes in body fat (p = 0.03). At 2 years, the associations remained statistically significant for changes in body weight (p = 0.02), BMI (p = 0.02) and WC (p = 0.048) in the low-fat diet group, although the gene–diet interaction became less significant.

Conclusions

The results suggest that carriers of the G allele of the MTNR1B rs10830963 may have a greater improvement in body adiposity and fat distribution when eating a low-fat diet.

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Title: A circadian rhythm-related MTNR1B genetic variant modulates the effect of weight-loss diets on changes in adiposity and body composition: the POUNDS Lost trial
Authors: Leticia Goni
Dianjianyi Sun
Yoriko Heianza
Tiange Wang
Tao Huang
J. Alfredo Martínez
Xiaoyun Shang
George A. Bray
Steven R. Smith
Frank M. Sacks
Lu Qi
Publication date: 01-06-2019
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 4/2019
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-018-1660-y

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A circadian rhythm-related MTNR1B genetic variant modulates the effect of weight-loss diets on changes in adiposity and body composition: the POUNDS Lost trial

Abstract

Purpose

Methods

Results

Conclusions

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