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01-03-2017 | Original Contribution

Vitamin D₃ supplementation does not modify cardiovascular risk profile of adults with inadequate vitamin D status

Authors: Eric Seibert, Ulrike Lehmann, Annett Riedel, Christof Ulrich, Frank Hirche, Corinna Brandsch, Jutta Dierkes, Matthias Girndt, Gabriele I. Stangl

Published in: European Journal of Nutrition | Issue 2/2017

Abstract

Purpose

The Nutrition Societies in Germany, Austria, and Switzerland recommend a daily intake of 20 µg vitamin D₃ for adults when endogenous synthesis is absent. The current study aimed to elucidate whether this vitamin D₃ dose impacts cardiovascular risk markers of adults during the winter months.

Methods

The study was conducted in Halle (Saale), Germany (51^o northern latitude) as a placebo-controlled, double-blinded, randomised trial (from January to April). A total of 105 apparently healthy subjects (male and female, 20–71 years old) were included. Subjects were randomly allocated to two groups. One group received a daily 20-µg vitamin D₃ dose (n = 54), and the other group received a placebo (n = 51) for 12 weeks. Outcome measures included blood pressure, heart rate, concentrations of renin, aldosterone, serum lipids and vascular calcification markers, and haematologic variables such as pro-inflammatory monocytes.

Results

Blood pressure and systemic cardiovascular risk markers remained unchanged by vitamin D₃ supplementation, although serum 25-hydroxyvitamin D₃ increased from 38 ± 14 to 73 ± 16 nmol/L at week 12. The placebo and vitamin D groups did not differ in their final cardiovascular risk profile.

Conclusion

Daily supplementation of 20 µg vitamin D₃ during winter is unlikely to change cardiovascular risk profile.

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Title: Vitamin D3 supplementation does not modify cardiovascular risk profile of adults with inadequate vitamin D status
Authors: Eric Seibert
Ulrike Lehmann
Annett Riedel
Christof Ulrich
Frank Hirche
Corinna Brandsch
Jutta Dierkes
Matthias Girndt
Gabriele I. Stangl
Publication date: 01-03-2017
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 2/2017
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-015-1106-8

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Purpose

Methods

Results

Conclusion

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