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European Journal of Nutrition
Published in: European Journal of Nutrition 8/2016

01-12-2016 | Original Contribution

Postnatal prebiotic fibre intake mitigates some detrimental metabolic outcomes of early overnutrition in rats

Authors: Danielle T. Reid, Lindsay K. Eller, Jodi E. Nettleton, Raylene A. Reimer

Published in: European Journal of Nutrition | Issue 8/2016

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Abstract

Purpose

Overnutrition during early development has been linked to metabolic disease and obesity in adulthood. Interventions to ameliorate this metabolic malprogramming are needed. Our objective was to determine whether prebiotic fibre would reduce weight gain and improve satiety hormone profiles in rats overnourished during the suckling period.

Methods

Male Sprague–Dawley rats reared in small litter (SL 3 pups) or normal litter (NL 12 pups) were randomized at weaning to AIN-93 (control) or a 10 % oligofructose (OFS) diet for 16 weeks. Body composition, an oral glucose tolerance test for glucose and gut hormones, and gut microbiota were assessed.

Results

At weaning, body weight was higher in SL than in NL rats (P < 0.03). At 19 weeks, body weight was lower with OFS than control (P < 0.04). There was a diet × litter size interaction wherein OFS in SL rats reduced body fat (%) to levels seen in NL rats (P < 0.05). OFS attenuated the glucose response in SL but not in NL rats (P < 0.015). Independent of litter size, OFS decreased total AUC for glucose-dependent insulinotropic polypeptide (P < 0.002) and increased total AUC for peptide YY (P < 0.01) and glucagon-like peptide-1 (P < 0.04) when compared to control. OFS, not litter size, played the predominant role in altering gut microbiota which included increased bifidobacteria and Akkermansia muciniphila with OFS.

Conclusions

Postnatal consumption of OFS by rats raised in SL was able to attenuate body fat and glycaemia to levels seen in NL rats. OFS appears to influence satiety hormone and gut microbiota response similarly in overnourished and control rats.
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Metadata
Title
Postnatal prebiotic fibre intake mitigates some detrimental metabolic outcomes of early overnutrition in rats
Authors
Danielle T. Reid
Lindsay K. Eller
Jodi E. Nettleton
Raylene A. Reimer
Publication date
01-12-2016
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nutrition / Issue 8/2016
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-015-1047-2

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Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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