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01-03-2013 | Original Contribution

Effects of lipoic acid on AMPK and adiponectin in adipose tissue of low- and high-fat-fed rats

Authors: Pedro L. Prieto-Hontoria, Patricia Pérez-Matute, Marta Fernández-Galilea, J. Alfredo Martínez, María J. Moreno-Aliaga

Published in: European Journal of Nutrition | Issue 2/2013

Abstract

Background

Lipoic acid (LA) is an antioxidant with antiobesity and antidiabetic properties. Adiponectin is an adipokine with potent anti-inflammatory and insulin-sensitizing properties. AMP-activated protein kinase (AMPK) is a key enzyme involved in cellular energy homeostasis. Activation of AMPK has been considered as a target to reverse the metabolic abnormalities associated with obesity and type 2 diabetes.

Aim of the study

The aim of this study was to determine the effects of LA on AMPK phosphorylation and adiponectin production in adipose tissue of low-fat (control diet) and high-fat diet-fed rats.

Results

Dietary supplementation with LA reduced body weight and adiposity in control and high-fat-fed rats. LA also reduced basal hyperinsulinemia as well as the homeostasis model assessment (HOMA) levels, an index of insulin resistance, in high-fat-fed rats, which was in part independent of their food intake lowering actions. Furthermore, AMPK phosphorylation was increased in white adipose tissue (WAT) from LA-treated rats as compared with pair-fed animals. Dietary supplementation with LA also upregulated adiponectin gene expression in WAT, while a negative correlation between adiposity-corrected adiponectin levels and HOMA index was found. Our present data suggest that the ability of LA supplementation to prevent insulin resistance in high-fat diet-fed rats might be related in part to the stimulation of AMPK and adiponectin in WAT.

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Title: Effects of lipoic acid on AMPK and adiponectin in adipose tissue of low- and high-fat-fed rats
Authors: Pedro L. Prieto-Hontoria
Patricia Pérez-Matute
Marta Fernández-Galilea
J. Alfredo Martínez
María J. Moreno-Aliaga
Publication date: 01-03-2013
Publisher: Springer-Verlag
Published in: European Journal of Nutrition / Issue 2/2013
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-012-0384-7

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Effects of lipoic acid on AMPK and adiponectin in adipose tissue of low- and high-fat-fed rats

Abstract

Background

Aim of the study

Results

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Abstract

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Results

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