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Published in: Clinical Research in Cardiology 4/2021

01-04-2021 | Magnetic Resonance Imaging | Review

Diagnosis and treatment of cardiac amyloidosis: position statement of the German Cardiac Society (DGK)

Authors: A. Yilmaz, J. Bauersachs, F. Bengel, R. Büchel, I. Kindermann, K. Klingel, F. Knebel, B. Meder, C. Morbach, E. Nagel, E. Schulze-Bahr, F. aus dem Siepen, N. Frey

Published in: Clinical Research in Cardiology | Issue 4/2021

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Abstract

Systemic forms of amyloidosis affecting the heart are mostly light-chain (AL) and transthyretin (ATTR) amyloidoses. The latter is caused by deposition of misfolded transthyretin, either in wild-type (ATTRwt) or mutant (ATTRv) conformation. For diagnostics, specific serum biomarkers and modern non-invasive imaging techniques, such as cardiovascular magnetic resonance imaging (CMR) and scintigraphic methods, are available today. These imaging techniques do not only complement conventional echocardiography, but also allow for accurate assessment of the extent of cardiac involvement, in addition to diagnosing cardiac amyloidosis. Endomyocardial biopsy still plays a major role in the histopathological diagnosis and subtyping of cardiac amyloidosis. The main objective of the diagnostic algorithm outlined in this position statement is to detect cardiac amyloidosis as reliably and early as possible, to accurately determine its extent, and to reliably identify the underlying subtype of amyloidosis, thereby enabling subsequent targeted treatment.
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Metadata
Title
Diagnosis and treatment of cardiac amyloidosis: position statement of the German Cardiac Society (DGK)
Authors
A. Yilmaz
J. Bauersachs
F. Bengel
R. Büchel
I. Kindermann
K. Klingel
F. Knebel
B. Meder
C. Morbach
E. Nagel
E. Schulze-Bahr
F. aus dem Siepen
N. Frey
Publication date
01-04-2021
Publisher
Springer Berlin Heidelberg
Published in
Clinical Research in Cardiology / Issue 4/2021
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI
https://doi.org/10.1007/s00392-020-01799-3

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