Top

Published in:

01-12-2017 | Original Paper

Functional status and quality of life after transcatheter mitral valve repair: a prospective cohort study and systematic review

Authors: Christos Iliadis, Samuel Lee, Kathrin Kuhr, Clemens Metze, Anna-Sophie Matzik, Guido Michels, Volker Rudolph, Stephan Baldus, Roman Pfister

Published in: Clinical Research in Cardiology | Issue 12/2017

Abstract

Background

Estimating the quantitative effect of transcatheter mitral valve repair on functional parameters and quality of life is important for individual treatment decision-making.

Methods

We combined data from a prospective monocentric cohort study (N = 215) with data from a systematic literature review (PubMed search term “mitraclip”, till 30.04.2016) on patients undergoing MitraClip with at least mortality after discharge reported as an outcome. Effects on functional parameters were reported as range of mean change.

Results

36 observational studies and 1 randomized controlled trial were identified. Due to substantial heterogeneity of effect estimates (I ²-heterogeneity >75%) and inadequate quality of studies with a lack of comparison group in 97.4% and lack of an independent assessment of outcomes in 86.8%, no pooled estimates were calculated. All studies reported improvements of mean New York Heart Association (NYHA) class (0.5–1.9 classes), Short-Form (SF)-12/36 scores (4.4–9.2 for physical component score, 2.6–8.9 for mental component score), 6-min walk distance [(6MWD) 2–336 m] and Minnesota Living with Heart failure questionnaire (MLWHFQ) score (−7 to −18 points), with improvements regarded as clinically relevant in 20 of 29 studies for NYHA class, in all of 7 studies for SF12/36, in 9 of 15 studies for 6MWD and in all of 8 studies for MLWHFQ.

Conclusion

MitraClip therapy provides improvements in physical capacity, physical and mental functioning and disease-specific quality of life in the majority of patients. However, more comparative and high-quality studies are required for understanding the heterogeneity of results, which is crucial for optimal patient selection.

Available only for authorised users

Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M (2006) Burden of valvular heart diseases: a population-based study. Lancet 368(9540):1005–1011. doi:10.1016/S0140-6736(06)69208-8 CrossRefPubMed

Armeni P, Boscolo PR, Tarricone R, Capodanno D, Maggioni AP, Grasso C, Tamburino C, Maisano F (2016) Real-world cost effectiveness of MitraClip combined with Medical Therapy Versus Medical therapy alone in patients with moderate or severe mitral regurgitation. Int J Cardiol 209:153–160. doi:10.1016/j.ijcard.2016.01.212 CrossRefPubMed

Trochu JN, Le Tourneau T, Obadia JF, Caranhac G, Beresniak A (2015) Economic burden of functional and organic mitral valve regurgitation. Arch Cardiovasc Dis 108(2):88–96. doi:10.1016/j.acvd.2014.09.008 CrossRefPubMed

Mirabel M, Iung B, Baron G, Messika-Zeitoun D, Detaint D, Vanoverschelde JL, Butchart EG, Ravaud P, Vahanian A (2007) What are the characteristics of patients with severe, symptomatic, mitral regurgitation who are denied surgery? Eur Heart J 28(11):1358–1365. doi:10.1093/eurheartj/ehm001 CrossRefPubMed

Schwencke C, Bijuklic K, Ouarrak T, Lubos E, Schillinger W, Plicht B, Eggebrecht H, Baldus S, Schymik G, Boekstegers P, Hoffmann R, Senges J, Schofer J (2017) Impact of cardiac comorbidities on early and 1-year outcome after percutaneous mitral valve interventions: data from the German transcatheter mitral valve interventions (TRAMI) registry. Clin Res Cardiol 106(4):249–258. doi:10.1007/s00392-016-1044-3 CrossRefPubMed

Wallenborn J, Stork S, Herrmann S, Kukuy O, Fette G, Puppe F, Gorski A, Hu K, Voelker W, Ertl G, Weidemann F (2016) Prevalence of severe mitral regurgitation eligible for edge-to-edge mitral valve repair (MitraClip). Clin Res Cardiol 105(8):699–709. doi:10.1007/s00392-016-0975-z CrossRefPubMed

De Bonis M, Al-Attar N, Antunes M, Borger M, Casselman F, Falk V, Folliguet T, Iung B, Lancellotti P, Lentini S, Maisano F, Messika-Zeitoun D, Muneretto C, Pibarot P, Pierard L, Punjabi P, Rosenhek R, Suwalski P, Vahanian A, Wendler O, Prendergast B (2016) Surgical and interventional management of mitral valve regurgitation: a position statement from the European Society of Cardiology Working Groups on Cardiovascular Surgery and Valvular Heart Disease. Eur Heart J 37(2):133–139. doi:10.1093/eurheartj/ehv322 CrossRefPubMed

Feldman T, Foster E, Glower DD, Kar S, Rinaldi MJ, Fail PS, Smalling RW, Siegel R, Rose GA, Engeron E, Loghin C, Trento A, Skipper ER, Fudge T, Letsou GV, Massaro JM, Mauri L (2011) Percutaneous repair or surgery for mitral regurgitation. N Engl J Med 364(15):1395–1406. doi:10.1056/NEJMoa1009355 CrossRefPubMed

Maisano F, Franzen O, Baldus S, Schafer U, Hausleiter J, Butter C, Ussia GP, Sievert H, Richardt G, Widder JD, Moccetti T, Schillinger W (2013) Percutaneous mitral valve interventions in the real world: early and 1-year results from the ACCESS-EU, a prospective, multicenter, nonrandomized post-approval study of the MitraClip therapy in Europe. J Am Coll Cardiol 62(12):1052–1061. doi:10.1016/j.jacc.2013.02.094 CrossRefPubMed

10.

Mauri L, Garg P, Massaro JM, Foster E, Glower D, Mehoudar P, Powell F, Komtebedde J, McDermott E, Feldman T (2010) The EVEREST II Trial: design and rationale for a randomized study of the evalve mitraclip system compared with mitral valve surgery for mitral regurgitation. Am Heart J 160(1):23–29. doi:10.1016/j.ahj.2010.04.009 CrossRefPubMed

11.

Nickenig G, Estevez-Loureiro R, Franzen O, Tamburino C, Vanderheyden M, Luscher TF, Moat N, Price S, Dall’Ara G, Winter R, Corti R, Grasso C, Snow TM, Jeger R, Blankenberg S, Settergren M, Tiroch K, Balzer J, Petronio AS, Buttner HJ, Ettori F, Sievert H, Fiorino MG, Claeys M, Ussia GP, Baumgartner H, Scandura S, Alamgir F, Keshavarzi F, Colombo A, Maisano F, Ebelt H, Aruta P, Lubos E, Plicht B, Schueler R, Pighi M, Di Mario C (2014) Percutaneous mitral valve edge-to-edge repair: in-hospital results and 1-year follow-up of 628 patients of the 2011–2012 Pilot European Sentinel Registry. J Am Coll Cardiol 64(9):875–884. doi:10.1016/j.jacc.2014.06.1166 CrossRefPubMed

12.

Puls M, Lubos E, Boekstegers P, von Bardeleben RS, Ouarrak T, Butter C, Zuern CS, Bekeredjian R, Sievert H, Nickenig G, Eggebrecht H, Senges J, Schillinger W (2016) One-year outcomes and predictors of mortality after MitraClip therapy in contemporary clinical practice: results from the German transcatheter mitral valve interventions registry. Eur Heart J 37(8):703–712. doi:10.1093/eurheartj/ehv627 CrossRefPubMed

13.

Zuern CS, Bauer A, Lubos E, Boekstegers P, Puls M, Bardeleben RS, Ouarrak T, Butter C, Eggebrecht H, Nickenig G, Zahn R, Senges J, May AE (2015) Influence of non-cardiac comorbidities on outcome after percutaneous mitral valve repair: results from the German transcatheter mitral valve interventions (TRAMI) registry. Clin Res Cardiol 104(12):1044–1053. doi:10.1007/s00392-015-0872-x CrossRefPubMed

14.

Abdelghani M, Cavalcante R, Miyazaki Y, de Winter RJ, Sarmento-Leite R, Mangione JA, Abizaid A, Lemos PA, Serruys PW, de Brito FS Jr. (2017) Prevalence, predictors, and prognostic implications of residual impairment of functional capacity after transcatheter aortic valve implantation. Clin Res Cardiol. doi:10.1007/s00392-017-1119-9 PubMedPubMedCentral

15.

Bunz M, Lenski D, Wedegartner S, Ukena C, Karbach J, Bohm M, Kindermann I (2016) Heart-focused anxiety in patients with chronic heart failure before implantation of an implantable cardioverter defibrillator: baseline findings of the Anxiety-CHF Study. Clin Res Cardiol 105(3):216–224. doi:10.1007/s00392-015-0909-1 CrossRefPubMed

16.

Boekstegers P, Hausleiter J, Baldus S, von Bardeleben RS, Beucher H, Butter C, Franzen O, Hoffmann R, Ince H, Kuck KH, Rudolph V, Schafer U, Schillinger W, Wunderlich N (2014) Percutaneous interventional mitral regurgitation treatment using the Mitra-Clip system. Clin Res Cardiol 103(2):85–96. doi:10.1007/s00392-013-0614-x CrossRefPubMed

17.

Rasekaba T, Lee AL, Naughton MT, Williams TJ, Holland AE (2009) The six-minute walk test: a useful metric for the cardiopulmonary patient. Intern Med J 39(8):495–501. doi:10.1111/j.1445-5994.2008.01880.x CrossRefPubMed

18.

Rector TS, Kubo SH, Cohn JN (1987) Patients’ self-assessment of their congestive heart failure: content, reliability, and validity of a new measure, the Minnesota Living with Heart Failure questionnaire. Heart Fail 3:198–209

19.

Muller-Nordhorn J, Roll S, Willich SN (2004) Comparison of the short form (SF)-12 health status instrument with the SF-36 in patients with coronary heart disease. Heart 90(5):523–527CrossRefPubMedPubMedCentral

20.

Ware J Jr, Kosinski M, Keller SD (1996) A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care 34(3):220–233CrossRefPubMed

21.

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 6(7):e1000100. doi:10.1371/journal.pmed.1000100 CrossRefPubMedPubMedCentral

22.

Gonzalez FM, Finch AP, Armeni P, Boscolo PR, Tarricone R (2015) Comparative effectiveness of Mitraclip plus medical therapy versus medical therapy alone in high-risk surgical patients: a comprehensive review. Expert Rev Med Devices 12(4):471–485. doi:10.1586/17434440.2015.1054807 CrossRefPubMed

23.

D’Ascenzo F, Moretti C, Marra WG, Montefusco A, Omede P, Taha S, Castagno D, Gaemperli O, Taramasso M, Frea S, Pidello S, Rudolph V, Franzen O, Braun D, Giannini C, Ince H, Perl L, Zoccai G, Marra S, D’Amico M, Maisano F, Rinaldi M, Gaita F (2015) Meta-analysis of the usefulness of Mitraclip in patients with functional mitral regurgitation. Am J Cardiol 116(2):325–331. doi:10.1016/j.amjcard.2015.04.025 CrossRefPubMed

24.

Bail DH (2015) (Meta)-analysis of safety and efficacy following edge-to-edge mitral valve repair using the MitraClip system. J Interv Cardiol 28(1):69–75. doi:10.1111/joic.12168 CrossRefPubMed

25.

Philip F, Athappan G, Tuzcu EM, Svensson LG, Kapadia SR (2014) MitraClip for severe symptomatic mitral regurgitation in patients at high surgical risk: a comprehensive systematic review. Catheter Cardiovasc Interv 84(4):581–590. doi:10.1002/ccd.25564 CrossRefPubMed

26.

Wan B, Rahnavardi M, Tian DH, Phan K, Munkholm-Larsen S, Bannon PG, Yan TD (2013) A meta-analysis of MitraClip system versus surgery for treatment of severe mitral regurgitation. Ann Cardiothorac Surg 2(6):683–692. doi:10.3978/j.issn.2225-319X.2013.11.02 PubMedPubMedCentral

27.

Orban M, Braun D, Sonne C, Thaler R, Grebmer C, Lesevic H, Schomig A, Mehilli J, Massberg S, Hausleiter J (2014) Dangerous liaison: successful percutaneous edge-to-edge mitral valve repair in patients with end-stage systolic heart failure can cause left ventricular thrombus formation. EuroIntervention 10(2):253–259. doi:10.4244/EIJV10I2A41 CrossRefPubMed

28.

Munkholm-Larsen S, Wan B, Tian DH, Kearney K, Rahnavardi M, Dixen U, Kober L, Alfieri O, Yan TD (2014) A systematic review on the safety and efficacy of percutaneous edge-to-edge mitral valve repair with the MitraClip system for high surgical risk candidates. Heart 100(6):473–478. doi:10.1136/heartjnl-2013-304049 CrossRefPubMed

29.

Kind P (1996) Quality of life and pharmacoeconomics in clinical trials. The EuroQoL instrument: an index of health-related quality of life. Lippincott-Raven, Philadelphia, pp 191–201

30.

Wiebe J, Franke J, Lubos E, Boekstegers P, Schillinger W, Ouarrak T, May AE, Eggebrecht H, Kuck KH, Baldus S, Senges J, Sievert H (2014) Percutaneous mitral valve repair with the MitraClip system according to the predicted risk by the logistic EuroSCORE: preliminary results from the German Transcatheter Mitral Valve Interventions (TRAMI) Registry. Catheter Cardiovasc Interv 84(4):591–598. doi:10.1002/ccd.25493 CrossRefPubMed

31.

Puls M, Tichelbacker T, Bleckmann A, Hunlich M, von der Ehe K, Beuthner BE, Ruter K, Beissbarth T, Seipelt R, Schondube F, Hasenfuss G, Schillinger W (2014) Failure of acute procedural success predicts adverse outcome after percutaneous edge-to-edge mitral valve repair with MitraClip. EuroIntervention 9(12):1407–1417. doi:10.4244/EIJV9I12A238 CrossRefPubMed

32.

Schueler R, Momcilovic D, Weber M, Welz A, Werner N, Mueller C, Ghanem A, Nickenig G, Hammerstingl C (2014) Acute changes of mitral valve geometry during interventional edge-to-edge repair with the MitraClip system are associated with midterm outcomes in patients with functional valve disease: preliminary results from a prospective single-center study. Circ Cardiovasc Interv 7(3):390–399. doi:10.1161/CIRCINTERVENTIONS.113.001098 CrossRefPubMed

33.

Pleger ST, Schulz-Schonhagen M, Geis N, Mereles D, Chorianopoulos E, Antaredja M, Lewening M, Katus HA, Bekeredjian R (2013) One year clinical efficacy and reverse cardiac remodelling in patients with severe mitral regurgitation and reduced ejection fraction after MitraClip implantation. Eur J Heart Fail 15(8):919–927. doi:10.1093/eurjhf/hft046 CrossRefPubMed

34.

Neuss M, Schau T, Schoepp M, Seifert M, Holschermann F, Meyhofer J, Butter C (2013) Patient selection criteria and midterm clinical outcome for MitraClip therapy in patients with severe mitral regurgitation and severe congestive heart failure. Eur J Heart Fail 15(7):786–795. doi:10.1093/eurjhf/hfs214 CrossRefPubMed

35.

Tigges E, Kalbacher D, Thomas C, Appelbaum S, Deuschl F, Schofer N, Schluter M, Conradi L, Schirmer J, Treede H, Reichenspurner H, Blankenberg S, Schafer U, Lubos E (2016) Transcatheter mitral valve repair in surgical high-risk patients: gender-specific acute and long-term outcomes. Biomed Res Int 2016:3934842. doi:10.1155/2016/3934842 CrossRefPubMedPubMedCentral

36.

Nikendei C, Schafer H, Weisbrod M, Huber J, Geis N, Katus HA, Bekeredjian R, Herzog W, Pleger ST, Schultz JH (2016) The effects of mitral valve repair on memory performance, executive function, and psychological measures in patients with heart failure. Psychosom Med 78(4):432–442. doi:10.1097/PSY.0000000000000284 CrossRefPubMed

37.

Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M et al (2016) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 14 July 2016

38.

Ahmed A, Aronow WS, Fleg JL (2006) Higher New York Heart Association classes and increased mortality and hospitalization in patients with heart failure and preserved left ventricular function. Am Heart J 151(2):444–450. doi:10.1016/j.ahj.2005.03.066 CrossRefPubMedPubMedCentral

39.

Wyrwich KW, Spertus JA, Kroenke K, Tierney WM, Babu AN, Wolinsky FD (2004) Clinically important differences in health status for patients with heart disease: an expert consensus panel report. Am Heart J 147(4):615–622. doi:10.1016/j.ahj.2003.10.039 CrossRefPubMed

40.

Walters SJ, Brazier JE (2005) Comparison of the minimally important difference for two health state utility measures: EQ-5D and SF-6D. Qual Life Res 14(6):1523–1532CrossRefPubMed

41.

Rector TS, Tschumperlin LK, Kubo SH, Bank AJ, Francis GS, McDonald KM, Keeler CA, Silver MA (1995) Use of the Living With Heart Failure questionnaire to ascertain patients’ perspectives on improvement in quality of life versus risk of drug-induced death. J Card Fail 1(3):201–206CrossRefPubMed

42.

Ferreira JP, Duarte K, Graves TL, Zile MR, Abraham WT, Weaver FA, Lindenfeld J, Zannad F (2016) Natriuretic peptides, 6-min walk test, and quality-of-life questionnaires as clinically meaningful endpoints in HF trials. J Am Coll Cardiol 68(24):2690–2707. doi:10.1016/j.jacc.2016.09.936 CrossRefPubMed

43.

Stone GW, Vahanian AS, Adams DH, Abraham WT, Borer JS, Bax JJ, Schofer J, Cutlip DE, Krucoff MW, Blackstone EH, Genereux P, Mack MJ, Siegel RJ, Grayburn PA, Enriquez-Sarano M, Lancellotti P, Filippatos G, Kappetein AP (2015) Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 1: clinical trial design principles: a consensus document from the mitral valve academic research consortium. Eur Heart J 36(29):1851–1877. doi:10.1093/eurheartj/ehv281 CrossRefPubMed

44.

Stone GW, Adams DH, Abraham WT, Kappetein AP, Genereux P, Vranckx P, Mehran R, Kuck KH, Leon MB, Piazza N, Head SJ, Filippatos G, Vahanian AS (2015) Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 2: endpoint definitions: a consensus document from the Mitral Valve Academic Research Consortium. Eur Heart J 36(29):1878–1891. doi:10.1093/eurheartj/ehv333 CrossRefPubMed

45.

Glower DD, Kar S, Trento A, Lim DS, Bajwa T, Quesada R, Whitlow PL, Rinaldi MJ, Grayburn P, Mack MJ, Mauri L, McCarthy PM, Feldman T (2014) Percutaneous mitral valve repair for mitral regurgitation in high-risk patients: results of the EVEREST II study. J Am Coll Cardiol 64(2):172–181. doi:10.1016/j.jacc.2013.12.062 CrossRefPubMed

46.

Higgins JPT (2011) Selecting studies and collecting data, Chap. 7. In: Higgins JPT, Green S (eds) Cochrane handbook for systematic reviews of interventions version 5.1.0 (updated March 2011). The Cochrane Collaboration. http://www.handbook.cochrane.org

47.

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188CrossRefPubMed

48.

Haney EM, Huffman LH, Bougatsos C, Freeman M, Fu R, Steiner RD, Helfand M, Nelson HD (2007). In: Screening for lipid disorders in children and adolescents. U.S. Preventive Services Task Force Evidence Syntheses, formerly Systematic Evidence Reviews. Rockville

49.

Cacela D, Fiarresga A, Branco L, Galrinho A, Rio P, Selas M, Ferreira R (2015) Percutaneous treatment of mitral valve regurgitation: initial experience with the MitraClip device. Port J Cardiol 34(9):515–524. doi:10.1016/j.repc.2015.04.004

50.

Lesevic H, Sonne C, Braun D, Orban M, Pache J, Kastrati A, Schomig A, Mehilli J, Barthel P, Ott I, Sack G, Massberg S, Hausleiter J (2015) Acute and midterm outcome after MitraClip therapy in patients with severe mitral regurgitation and left ventricular dysfunction. Am J Cardiol 116(5):749–756. doi:10.1016/j.amjcard.2015.05.048 CrossRefPubMed

51.

Vitarelli A, Mangieri E, Capotosto L, Tanzilli G, D’Angeli I, Viceconte N, Placanica A, Placanica G, Cocco N, Ashurov R, Al-Kindy S (2015) Assessment of biventricular function by three-dimensional speckle-tracking echocardiography in secondary mitral regurgitation after repair with the MitraClip system. J Am Soc Echocardiogr 28(9):1070–1082. doi:10.1016/j.echo.2015.04.005 CrossRefPubMed

52.

Hellhammer K, Balzer J, Zeus T, Rammos C, Niebel S, Kubatz L, Wagstaff R, Kelm M, Rassaf T (2015) Percutaneous mitral valve repair using the MitraClip system in patients with anemia. Int J Cardiol 184:399–404. doi:10.1016/j.ijcard.2015.02.081 CrossRefPubMed

53.

Carrasco-Chinchilla F, Arzamendi D, Romero M, Gimeno de Carlos F, Alonso-Briales JH, Li CH, Mesa MD, Arnold R, Serrador Frutos AM, Pan M, Roig E, Rodriguez-Bailon I, de la Fuente Galan L, Hernandez JM, Serra A, Suarez de Lezo J (2014) Initial experience of percutaneous treatment of mitral regurgitation with MitraClip(R) therapy in Spain. Rev Esp Cardiol (Engl Ed) 67(12):1007–1012. doi:10.1016/j.rec.2014.02.019 CrossRef

54.

Matsumoto T, Nakamura M, Yeow WL, Hussaini A, Ram V, Makar M, Gurudevan SV, Trento A, Siegel RJ, Kar S (2014) Impact of pulmonary hypertension on outcomes in patients with functional mitral regurgitation undergoing percutaneous edge-to-edge repair. Am J Cardiol 114(11):1735–1739. doi:10.1016/j.amjcard.2014.08.044 CrossRefPubMed

55.

van Riel AC, Boerlage-van Dijk K, de Bruin-Bon RH, Araki M, Koch KT, Vis MM, Meregalli PG, van den Brink RB, Piek JJ, Mulder BJ, Baan J Jr, Bouma BJ (2014) Percutaneous mitral valve repair preserves right ventricular function. J Am Soc Echocardiogr 27(10):1098–1106. doi:10.1016/j.echo.2014.06.001 CrossRefPubMed

56.

Vandendriessche T, Kotrc M, Tijskens M, Bartunek J, Delesie M, Paelinck BP, De Bock D, Penicka M, Stockman B, De Maeyer C, Vrints C, Vanderheyden M, Claeys MJ (2014) Percutaneous mitral valve repair in high-risk patients: initial experience with the Mitraclip system in Belgium. Acta Cardiol 69(3):265–270. doi:10.2143/AC.69.3.3027829 CrossRefPubMed

57.

Taramasso M, Maisano F, Denti P, Latib A, La Canna G, Colombo A, Alfieri O (2014) Percutaneous edge-to-edge repair in high-risk and elderly patients with degenerative mitral regurgitation: midterm outcomes in a single-center experience. J Thorac Cardiovasc Surg 148(6):2743–2750. doi:10.1016/j.jtcvs.2014.03.036 CrossRefPubMed

58.

Koifman E, Fefer P, Hay I, Feinberg M, Maor E, Guetta V (2014) MitraClip implantation for high risk patients with severe mitral regurgitation: the Sheba experience. Isr Med Assoc J 16(2):91–95PubMed

59.

Taramasso M, Maisano F, Latib A, Denti P, Buzzatti N, Cioni M, La Canna G, Colombo A, Alfieri O (2014) Clinical outcomes of MitraClip for the treatment of functional mitral regurgitation. EuroIntervention 10(6):746–752. doi:10.4244/EIJV10I6A128 CrossRefPubMed

60.

Bozdag-Turan I, Paranskaya L, Birkemeyer R, Turan RG, Kische S, Akin I, Ortak J, Stoeckicht Y, Schubert J, Westphal B, Nienaber CA, Ince H (2014) Percutaneous mitral repair with the MitraClip system in patients with mild-to-moderate and severe heart failure: a single-centre experience. Cardiovasc Ther 32(2):66–73. doi:10.1111/1755-5922.12058 CrossRefPubMed

61.

Perl L, Vaturi M, Assali A, Shapira Y, Bruckheimer E, Ben-Gal T, Vaknin-Assa H, Sagie A, Kornowski R (2013) Preliminary experience using the transcatheter mitral valve leaflet repair procedure. Isr Med Assoc J 15(10):608–612PubMed

62.

Estevez-Loureiro R, Franzen O, Winter R, Sondergaard L, Jacobsen P, Cheung G, Moat N, Ihlemann N, Ghione M, Price S, Duncan A, Streit Rosenberg T, Barker S, Di Mario C, Settergren M (2013) Echocardiographic and clinical outcomes of central versus noncentral percutaneous edge-to-edge repair of degenerative mitral regurgitation. J Am Coll Cardiol 62(25):2370–2377. doi:10.1016/j.jacc.2013.05.093 CrossRefPubMed

63.

Armoiry X, Brochet E, Lefevre T, Guerin P, Dumonteil N, Himbert D, Cormier B, Piriou N, Gautier M, Messika-Zeitoun D, Romano M, Rioufol G, Warin Fresse K, Boudou N, Leclercq F, Bedossa M, Obadia JF (2013) Initial French experience of percutaneous mitral valve repair with the MitraClip: a multicentre national registry. Arch Cardiovasc Dis 106(5):287–294. doi:10.1016/j.acvd.2013.03.059 CrossRefPubMed

64.

Surder D, Pedrazzini G, Gaemperli O, Biaggi P, Felix C, Rufibach K, der Maur CA, Jeger R, Buser P, Kaufmann BA, Moccetti M, Hurlimann D, Buhler I, Bettex D, Scherman J, Pasotti E, Faletra FF, Zuber M, Moccetti T, Luscher TF, Erne P, Grunenfelder J, Corti R (2013) Predictors for efficacy of percutaneous mitral valve repair using the MitraClip system: the results of the MitraSwiss registry. Heart 99(14):1034–1040. doi:10.1136/heartjnl-2012-303105 CrossRefPubMed

65.

Spargias K, Chrissoheris M, Halapas A, Nikolaou J, Tsolakis A, Bouboulis N, Pattakos S (2012) Percutaneous mitral valve repair using the edge-to-edge technique: first Greek experience. Hell J Cardiol 53(5):343–351

66.

Ussia GP, Cammalleri V, Sarkar K, Scandura S, Imme S, Pistritto AM, Caggegi A, Chiaranda M, Mangiafico S, Barbanti M, Scarabelli M, Mule M, Aruta P, Tamburino C (2012) Quality of life following percutaneous mitral valve repair with the MitraClip system. Int J Cardiol 155(2):194–200. doi:10.1016/j.ijcard.2011.08.853 CrossRefPubMed

67.

Ihlemann N, Franzen O, Jorgensen E, Hansen PB, Hassager C, Moller JE, Sondergaard L (2011) Promising results after percutaneous mitral valve repair. Dan Med Bull 58(7):A4299PubMed

68.

Feldman T, Kar S, Rinaldi M, Fail P, Hermiller J, Smalling R, Whitlow PL, Gray W, Low R, Herrmann HC, Lim S, Foster E, Glower D (2009) Percutaneous mitral repair with the MitraClip system: safety and midterm durability in the initial EVEREST (Endovascular Valve Edge-to-Edge REpair Study) cohort. J Am Coll Cardiol 54(8):686–694. doi:10.1016/j.jacc.2009.03.077 CrossRefPubMed

69.

Kasner M, Gast M, Galuszka O, Stroux A, Rutschow S, Wang X, Dohmen P, Skurk C, Landmesser U, Poller W, Gross M (2016) Circulating exosomal microRNAs predict functional recovery after MitraClip repair of severe mitral regurgitation. Int J Cardiol 215:402–405. doi:10.1016/j.ijcard.2016.04.018 CrossRefPubMed

70.

Adamo M, Chiari E, Curello S, Maiandi C, Chizzola G, Fiorina C, Frontini M, Cuminetti G, Pezzotti E, Rovetta R, Lombardi CM, Manzato A, Metra M, Ettori F (2016) Mitraclip therapy in patients with functional mitral regurgitation and missing leaflet coaptation: is it still an exclusion criterion? Eur J Heart Fail 18(10):1278–1286. doi:10.1002/ejhf.520 CrossRefPubMed

71.

Sorajja P, Mack M, Vemulapalli S, Holmes DR Jr, Stebbins A, Kar S, Lim DS, Thourani V, McCarthy P, Kapadia S, Grayburn P, Pedersen WA, Ailawadi G (2016) Initial experience with commercial transcatheter mitral valve repair in the United States. J Am Coll Cardiol 67(10):1129–1140. doi:10.1016/j.jacc.2015.12.054 CrossRefPubMed

72.

Azzalini L, Millan X, Khan R, Couture P, Ducharme A, Basmadjian A, Bonan R, Asgar AW (2016) Impact of left ventricular function on clinical outcomes of functional mitral regurgitation patients undergoing transcatheter mitral valve repair. Catheter Cardiovasc Interv. doi:10.1002/ccd.26460

73.

Ussia GP, Cammalleri V, Mazzotta E, Pascuzzo G, Muscoli S, Marchei M, Macrini M, Anceschi A, Romeo F (2016) Cardiovascular medicine heart failure (CVM-HF) index as prognostic model for candidates to MitraClip therapy. Heart Vessels 31(10):1633–1642. doi:10.1007/s00380-015-0772-z CrossRefPubMed

74.

Tay E, Muda N, Yap J, Muller DW, Santoso T, Walters DL, Liu X, Yamen E, Jansz P, Yip J, Zambahari R, Passage J, Ding ZP, Wang J, Scalia G, Soesanto AM, Yeo KK (2016) The MitraClip Asia-Pacific registry: differences in outcomes between functional and degenerative mitral regurgitation. Catheter Cardiovasc Interv 87(7):E275–E281. doi:10.1002/ccd.26289 CrossRefPubMed

75.

Van den Branden BJ, Swaans MJ, Post MC, Rensing BJ, Eefting FD, Jaarsma W, Van der Heyden JA (2012) Percutaneous edge-to-edge mitral valve repair in high-surgical-risk patients: do we hit the target? JACC Cardiovasc Interv 5(1):105–111. doi:10.1016/j.jcin.2011.09.013 CrossRefPubMed

76.

Giannini C, Fiorelli F, De Carlo M, Guarracino F, Faggioni M, Giordano P, Spontoni P, Pieroni A, Petronio AS (2016) Comparison of percutaneous mitral valve repair versus conservative treatment in severe functional mitral regurgitation. Am J Cardiol 117(2):271–277. doi:10.1016/j.amjcard.2015.10.044 CrossRefPubMed

77.

Schueler R, Nickenig G, May AE, Schillinger W, Bekeredjian R, Ouarrak T, Schofer J, Hehrlein C, Sievert H, Boekstegers P, Lubos E, Hoffmann R, Baldus S, Senges J, Hammerstingl C (2016) Predictors for short-term outcomes of patients undergoing transcatheter mitral valve interventions: analysis of 778 prospective patients from the German TRAMI registry focusing on baseline renal function. EuroIntervention 12(4):508–514. doi:10.4244/EIJY15M09_07 CrossRefPubMed

78.

Kobe J, Hucklenbroich K, Geisendorfer N, Bettin M, Frommeyer G, Reinke F, Dechering D, Burgmer M, Eckardt L (2017) Posttraumatic stress and quality of life with the totally subcutaneous compared to conventional cardioverter-defibrillator systems. Clin Res Cardiol 106(5):317–321. doi:10.1007/s00392-016-1055-0 CrossRefPubMed

79.

Tan MK, Jarral OA, Thong EH, Kidher E, Uppal R, Punjabi PP, Athanasiou T (2017) Quality of life after mitral valve intervention. Interact Cardiovasc Thorac Surg 24(2):265–272. doi:10.1093/icvts/ivw312 PubMed

80.

Stone GW, Vahanian AS, Adams DH, Abraham WT, Borer JS, Bax JJ, Schofer J, Cutlip DE, Krucoff MW, Blackstone EH, Genereux P, Mack MJ, Siegel RJ, Grayburn PA, Enriquez-Sarano M, Lancellotti P, Filippatos G, Kappetein AP (2015) Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 1: clinical trial design principles: a consensus document from the mitral valve academic research consortium. J Am Coll Cardiol 66(3):278–307. doi:10.1016/j.jacc.2015.05.046 CrossRefPubMed

81.

Stone GW, Adams DH, Abraham WT, Kappetein AP, Genereux P, Vranckx P, Mehran R, Kuck KH, Leon MB, Piazza N, Head SJ, Filippatos G, Vahanian AS (2015) Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 2: endpoint definitions: a consensus document from the mitral valve academic research consortium. J Am Coll Cardiol 66(3):308–321. doi:10.1016/j.jacc.2015.05.049 CrossRefPubMed

82.

Bagur R, Rodes-Cabau J, Dumont E, De Larochelliere R, Doyle D, Pibarot P, Cote M, Clavel MA, Villeneuve J, Gutierrez M, Poirier P, Bertrand OF (2011) Performance-based functional assessment of patients undergoing transcatheter aortic valve implantation. Am Heart J 161(4):726–734. doi:10.1016/j.ahj.2010.12.024 CrossRefPubMed

83.

Raphael C, Briscoe C, Davies J, Ian Whinnett Z, Manisty C, Sutton R, Mayet J, Francis DP (2007) Limitations of the New York Heart Association functional classification system and self-reported walking distances in chronic heart failure. Heart 93(4):476–482. doi:10.1136/hrt.2006.089656 CrossRefPubMed

84.

Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, Kocovic DZ, Packer M, Clavell AL, Hayes DL, Ellestad M, Trupp RJ, Underwood J, Pickering F, Truex C, McAtee P, Messenger J (2002) Cardiac resynchronization in chronic heart failure. N Engl J Med 346(24):1845–1853. doi:10.1056/NEJMoa013168 CrossRefPubMed

Title: Functional status and quality of life after transcatheter mitral valve repair: a prospective cohort study and systematic review
Authors: Christos Iliadis
Samuel Lee
Kathrin Kuhr
Clemens Metze
Anna-Sophie Matzik
Guido Michels
Volker Rudolph
Stephan Baldus
Roman Pfister
Publication date: 01-12-2017
Publisher: Springer Berlin Heidelberg
Published in: Clinical Research in Cardiology / Issue 12/2017
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-017-1150-x

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Functional status and quality of life after transcatheter mitral valve repair: a prospective cohort study and systematic review

Abstract

Background

Methods

Results

Conclusion

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 12/2017

Circadian rhythm of blood cardiac troponin T concentration

Transcatheter aortic valve implantation in patients with a reduced left ventricular ejection fraction: a single-centre experience in 2000 patients (TAVIK Registry)

Biological variation of extracellular matrix biomarkers in patients with stable chronic heart failure

Multicenter, randomized comparison between magnetically navigated and manually guided radiofrequency ablation of atrioventricular nodal reentrant tachycardia (the MagMa-AVNRT-trial)

Adherence to optimal heart rate control in heart failure with reduced ejection fraction: insight from a survey of heart rate in heart failure in Sweden (HR-HF study)

Impact of left main coronary artery disease on long-term mortality in patients undergoing drug-eluting stent implantation

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page