Skip to main content
Top
Published in: Clinical Research in Cardiology 11/2017

Open Access 01-11-2017 | Original Paper

Epidemiology of heart failure in Germany: a retrospective database study

Authors: Stefan Störk, Renate Handrock, Josephine Jacob, Jochen Walker, Frederico Calado, Raquel Lahoz, Stephan Hupfer, Sven Klebs

Published in: Clinical Research in Cardiology | Issue 11/2017

Login to get access

Abstract

Background

Chronic heart failure (HF) is associated with significant healthcare expenditure, morbidity, and mortality. This study investigated the epidemiology of HF in Germany.

Methods

This retrospective study used anonymous healthcare claims data from the German Health Risk Institute on individuals with statutory health insurance. Patients with uninterrupted data from 1 January 2009 to 31 December 2013 or death (whichever occurred first), and ≥2 recorded HF-related diagnoses in 2011, were included. Patients with newly diagnosed HF were identified. Patients were followed up for 2 years from first diagnosis.

Results

Of 3,132,337 eligible patients, 123,925 (55.0% women; mean age 76.2 years) had HF: a prevalence of 3.96%. Of these, 26,368 had newly diagnosed HF: an incidence of 655/100,000 persons at risk. Incidence increased with age and was similar regardless of sex. During follow-up, there were 48,159 hospital admissions among newly diagnosed patients (1.8 hospitalizations/patient/2 years); HF accounted for 6% of these. Additionally, 20,148 patients (16.3%) overall and 5983 newly diagnosed patients (22.7%) died. Most new cases of HF were diagnosed by office-based physicians (63.2%); new cases among hospital inpatients were predominantly diagnosed by internal medicine specialists (70.7%). Overall, 94.0% received their initial prescription for HF treatment from a family practitioner.

Conclusions

The high prevalence and incidence observed in this representative sample emphasize the burden of HF in Germany. Substantial hospitalization rates and mortality highlight the need for early diagnosis and appropriate treatment, and for close cooperation between physician specialties and healthcare sectors.
Appendix
Available only for authorised users
Literature
2.
go back to reference Braunwald E (1997) Shattuck lecture—cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. N Engl J Med 337:1360–1369CrossRefPubMed Braunwald E (1997) Shattuck lecture—cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. N Engl J Med 337:1360–1369CrossRefPubMed
3.
go back to reference Bui AL, Horwich TB, Fonarow GC (2011) Epidemiology and risk profile of heart failure. Nat Rev Cardiol 8:30–41CrossRefPubMed Bui AL, Horwich TB, Fonarow GC (2011) Epidemiology and risk profile of heart failure. Nat Rev Cardiol 8:30–41CrossRefPubMed
4.
go back to reference Cowie MR, Wood DA, Coats AJ, Thompson SG, Poole-Wilson PA, Suresh V, Sutton GC (1999) Incidence and aetiology of heart failure; a population-based study. Eur Heart J 20:421–428CrossRefPubMed Cowie MR, Wood DA, Coats AJ, Thompson SG, Poole-Wilson PA, Suresh V, Sutton GC (1999) Incidence and aetiology of heart failure; a population-based study. Eur Heart J 20:421–428CrossRefPubMed
5.
go back to reference Ho KK, Pinsky JL, Kannel WB, Levy D (1993) The epidemiology of heart failure: the Framingham Study. J Am Coll Cardiol 22:6a–13aCrossRefPubMed Ho KK, Pinsky JL, Kannel WB, Levy D (1993) The epidemiology of heart failure: the Framingham Study. J Am Coll Cardiol 22:6a–13aCrossRefPubMed
6.
go back to reference Zarrinkoub R, Wettermark B, Wandell P, Mejhert M, Szulkin R, Ljunggren G, Kahan T (2013) The epidemiology of heart failure, based on data for 2.1 million inhabitants in Sweden. Eur J Heart Fail 15:995–1002CrossRefPubMed Zarrinkoub R, Wettermark B, Wandell P, Mejhert M, Szulkin R, Ljunggren G, Kahan T (2013) The epidemiology of heart failure, based on data for 2.1 million inhabitants in Sweden. Eur J Heart Fail 15:995–1002CrossRefPubMed
7.
go back to reference Tiller D, Russ M, Greiser KH et al (2013) Prevalence of symptomatic heart failure with reduced and with normal ejection fraction in an elderly general population-the CARLA study. PLoS One 8:e59225CrossRefPubMedPubMedCentral Tiller D, Russ M, Greiser KH et al (2013) Prevalence of symptomatic heart failure with reduced and with normal ejection fraction in an elderly general population-the CARLA study. PLoS One 8:e59225CrossRefPubMedPubMedCentral
8.
go back to reference Ohlmeier C, Mikolajczyk R, Frick J, Prutz F, Haverkamp W, Garbe E (2015) Incidence, prevalence and 1-year all-cause mortality of heart failure in Germany: a study based on electronic healthcare data of more than six million persons. Clin Res Cardiol 104:688–696CrossRefPubMed Ohlmeier C, Mikolajczyk R, Frick J, Prutz F, Haverkamp W, Garbe E (2015) Incidence, prevalence and 1-year all-cause mortality of heart failure in Germany: a study based on electronic healthcare data of more than six million persons. Clin Res Cardiol 104:688–696CrossRefPubMed
9.
go back to reference Neumann T, Biermann J, Erbel R, Neumann A, Wasem J, Ertl G, Dietz R (2009) Heart failure: the commonest reason for hospital admission in Germany: medical and economic perspectives. Dtsch Arztebl Int 106:269–275PubMedPubMedCentral Neumann T, Biermann J, Erbel R, Neumann A, Wasem J, Ertl G, Dietz R (2009) Heart failure: the commonest reason for hospital admission in Germany: medical and economic perspectives. Dtsch Arztebl Int 106:269–275PubMedPubMedCentral
10.
go back to reference Christ M, Stork S, Dorr M, Heppner HJ, Muller C, Wachter R, Riemer U, For the Trend HF Germany Project (2016) Heart failure epidemiology 2000-2013: insights from the German Federal Health Monitoring System. Eur J Heart Fail 18:1009–1018CrossRefPubMed Christ M, Stork S, Dorr M, Heppner HJ, Muller C, Wachter R, Riemer U, For the Trend HF Germany Project (2016) Heart failure epidemiology 2000-2013: insights from the German Federal Health Monitoring System. Eur J Heart Fail 18:1009–1018CrossRefPubMed
11.
go back to reference Schmid T, Xu W, Gandra SR, Michailov GV (2015) Costs of treating cardiovascular events in Germany: a systematic literature review. Health Econ Rev 5:27CrossRefPubMedPubMedCentral Schmid T, Xu W, Gandra SR, Michailov GV (2015) Costs of treating cardiovascular events in Germany: a systematic literature review. Health Econ Rev 5:27CrossRefPubMedPubMedCentral
12.
go back to reference Andersohn F, Walker J (2016) Characteristics and external validity of the German Health Risk Institute (HRI) Database. Pharmacoepidemiol Drug Saf 25:106–109CrossRefPubMed Andersohn F, Walker J (2016) Characteristics and external validity of the German Health Risk Institute (HRI) Database. Pharmacoepidemiol Drug Saf 25:106–109CrossRefPubMed
14.
go back to reference Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373–383CrossRefPubMed Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373–383CrossRefPubMed
15.
go back to reference Pasternak B, Mattsson A, Svanstrom H, Hviid A (2015) Comparative effectiveness of bisoprolol and metoprolol succinate in patients with heart failure. Int J Cardiol 190:4–6CrossRefPubMed Pasternak B, Mattsson A, Svanstrom H, Hviid A (2015) Comparative effectiveness of bisoprolol and metoprolol succinate in patients with heart failure. Int J Cardiol 190:4–6CrossRefPubMed
16.
go back to reference Statistisches Bundesamt (ed) (2012) Diagnosedaten der Patienten und Patientinnen in Krankenhäusern (einschl. Sterbe- und Stundenfälle), Fachserie 12 Reihe 6.2.1 Statistisches Bundesamt (ed) (2012) Diagnosedaten der Patienten und Patientinnen in Krankenhäusern (einschl. Sterbe- und Stundenfälle), Fachserie 12 Reihe 6.2.1
17.
go back to reference Svanstrom H, Pasternak B, Melbye M, Hviid A (2015) Use of different types of angiotensin converting enzyme inhibitors and mortality in systolic heart failure. Int J Cardiol 182:90–96CrossRefPubMed Svanstrom H, Pasternak B, Melbye M, Hviid A (2015) Use of different types of angiotensin converting enzyme inhibitors and mortality in systolic heart failure. Int J Cardiol 182:90–96CrossRefPubMed
18.
go back to reference Schwabe U, Paffrath D (2012) Arzneiverordnungs-Report. Springer, Berlin Schwabe U, Paffrath D (2012) Arzneiverordnungs-Report. Springer, Berlin
19.
go back to reference Leitlinien und Empfehlungen zur Sicherung von Guter Epidemiologischer Praxis (GEP) (2009) Deutsche Gesellschaft für Epidemiologie Leitlinien und Empfehlungen zur Sicherung von Guter Epidemiologischer Praxis (GEP) (2009) Deutsche Gesellschaft für Epidemiologie
20.
go back to reference Gute Praxis Sekundärdatenanalyse (GPS) Leitlinien und Empfehlungen (3. Fassung) (2012) Arbeitsgruppe Erhebung und Nutzung von Sekundärdaten (AGENS), Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP), Deutschen Gesellschaftfür Epidemiologie (DGEpi) (eds) Gute Praxis Sekundärdatenanalyse (GPS) Leitlinien und Empfehlungen (3. Fassung) (2012) Arbeitsgruppe Erhebung und Nutzung von Sekundärdaten (AGENS), Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP), Deutschen Gesellschaftfür Epidemiologie (DGEpi) (eds)
21.
go back to reference Mosterd A, Hoes AW, de Bruyne MC, Deckers JW, Linker DT, Hofman A, Grobbee DE (1999) Prevalence of heart failure and left ventricular dysfunction in the general population; The Rotterdam Study. Eur Heart J 20:447–455CrossRefPubMed Mosterd A, Hoes AW, de Bruyne MC, Deckers JW, Linker DT, Hofman A, Grobbee DE (1999) Prevalence of heart failure and left ventricular dysfunction in the general population; The Rotterdam Study. Eur Heart J 20:447–455CrossRefPubMed
22.
go back to reference Maggioni AP, Anker SD, Dahlstrom U et al (2013) Are hospitalized or ambulatory patients with heart failure treated in accordance with European Society of Cardiology guidelines? Evidence from 12,440 patients of the ESC heart failure long-term registry. Eur J Heart Fail 15:1173–1184CrossRefPubMed Maggioni AP, Anker SD, Dahlstrom U et al (2013) Are hospitalized or ambulatory patients with heart failure treated in accordance with European Society of Cardiology guidelines? Evidence from 12,440 patients of the ESC heart failure long-term registry. Eur J Heart Fail 15:1173–1184CrossRefPubMed
23.
go back to reference McMurray JJ, Adamopoulos S, Anker SD et al (2012) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J 33:1787–1847CrossRefPubMed McMurray JJ, Adamopoulos S, Anker SD et al (2012) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J 33:1787–1847CrossRefPubMed
24.
go back to reference Metra M, Zaca V, Parati G et al (2011) Cardiovascular and noncardiovascular comorbidities in patients with chronic heart failure. J Cardiovasc Med (Hagerstown) 12:76–84CrossRef Metra M, Zaca V, Parati G et al (2011) Cardiovascular and noncardiovascular comorbidities in patients with chronic heart failure. J Cardiovasc Med (Hagerstown) 12:76–84CrossRef
25.
go back to reference Khunti K, Hearnshaw H, Baker R, Grimshaw G (2002) Heart failure in primary care: qualitative study of current management and perceived obstacles to evidence-based diagnosis and management by general practitioners. Eur J Heart Fail 4:771–777CrossRefPubMed Khunti K, Hearnshaw H, Baker R, Grimshaw G (2002) Heart failure in primary care: qualitative study of current management and perceived obstacles to evidence-based diagnosis and management by general practitioners. Eur J Heart Fail 4:771–777CrossRefPubMed
Metadata
Title
Epidemiology of heart failure in Germany: a retrospective database study
Authors
Stefan Störk
Renate Handrock
Josephine Jacob
Jochen Walker
Frederico Calado
Raquel Lahoz
Stephan Hupfer
Sven Klebs
Publication date
01-11-2017
Publisher
Springer Berlin Heidelberg
Published in
Clinical Research in Cardiology / Issue 11/2017
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI
https://doi.org/10.1007/s00392-017-1137-7

Other articles of this Issue 11/2017

Clinical Research in Cardiology 11/2017 Go to the issue