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01-08-2016 | Original Paper

Pulse pressure as an independent predictor of stroke: a systematic review and a meta-analysis

Authors: Feng-Di Liu, Xiao-Lei Shen, Rong Zhao, Xiao-Xiao Tao, Shuo Wang, Jia-Jun Zhou, Bo Zheng, Qi-Ting Zhang, Qian Yao, Ying Zhao, Xin Zhang, Xue-Mei Wang, Hui-Qin Liu, Liang Shu, Jian-Ren Liu

Published in: Clinical Research in Cardiology | Issue 8/2016

Abstract

Background

Recent evidence suggests that pulse pressure (PP) is a strong cardiovascular diseases’ risk factor. We systematically evaluated all relevant studies to determine whether PP can be used as an independent predictor of stroke and mortality.

Methods and results

A meta-analysis was performed by searching the published literature using MEDLINE, Cochrane and Google Scholar databases up to December 15, 2015. We measured the effect size expressed by hazard ratio (HR) and 95 % confidence interval (95 % CI). Eleven publications were included in the analysis. Pooled results demonstrated that 10 mmHg increase in PP was associated with increased risk of stroke occurrence (pooled HR 1.046, 95 % CI 1.025–1.068, P < 0.001). Additionally, systolic blood pressure (SBP) (pooled HR 1.053, 95 % CI 1.033–1.073, P < 0.001) and diastolic blood pressure (DPB) (pooled HR 1.056, 95 % CI 1.038–1.074, P < 0.001) were found to be significant predictors for stroke. We did not find a significant association between PP and all-cause mortality (pooled HR 1.022, 95 % CI 0.983–1.063, P = 0.270). We found SBP (pooled HR 1.008, 95 % CI 1.002–1.014, P = 0.012), but not DBP (pooled HR 1.023, 95 % CI 0.964–1.085, P = 0.451) to be significantly associated with all-cause mortality.

Conclusions

Current data confirms that PP is an independent risk factor for stroke but is not a predictor of mortality.

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Title: Pulse pressure as an independent predictor of stroke: a systematic review and a meta-analysis
Authors: Feng-Di Liu
Xiao-Lei Shen
Rong Zhao
Xiao-Xiao Tao
Shuo Wang
Jia-Jun Zhou
Bo Zheng
Qi-Ting Zhang
Qian Yao
Ying Zhao
Xin Zhang
Xue-Mei Wang
Hui-Qin Liu
Liang Shu
Jian-Ren Liu
Publication date: 01-08-2016
Publisher: Springer Berlin Heidelberg
Published in: Clinical Research in Cardiology / Issue 8/2016
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-016-0972-2

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