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Clinical Research in Cardiology
Published in: Clinical Research in Cardiology 8/2015

01-08-2015 | Review

Renal impairment and worsening of renal function in acute heart failure: can new therapies help? The potential role of serelaxin

Authors: Roland E. Schmieder, Veselin Mitrovic, Christian Hengstenberg

Published in: Clinical Research in Cardiology | Issue 8/2015

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Abstract

Renal dysfunction is a frequent finding in patients with acute heart failure (AHF) and an important prognostic factor for adverse outcomes. Worsening of renal function occurs in 30–50 % of patients hospitalised for AHF, and is associated with increased mortality, prolonged hospital stay and increased risk of readmission. Likely mechanisms involved in the decrease in renal function include impaired haemodynamics and activation of neurohormonal factors, such as the renin–angiotensin–aldosterone system, the sympathetic nervous system and the arginine–vasopressin system. Additionally, many drugs currently used to treat AHF have a detrimental effect on renal function. Therefore, pharmacotherapy for AHF should carefully take into account any potential complications related to renal function. Serelaxin, currently in clinical development for the treatment of AHF is a recombinant form of human relaxin-2, identical in structure to the naturally occurring human relaxin-2 peptide hormone that mediates cardiac and renal adaptations during pregnancy. Data from both pre-clinical and clinical studies indicate a potentially beneficial effect of serelaxin on kidney function. In this review, we discuss the mechanisms and impact of impairment of renal function in AHF, and the potential benefits of new therapies, such as serelaxin, in this context.
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Metadata
Title
Renal impairment and worsening of renal function in acute heart failure: can new therapies help? The potential role of serelaxin
Authors
Roland E. Schmieder
Veselin Mitrovic
Christian Hengstenberg
Publication date
01-08-2015
Publisher
Springer Berlin Heidelberg
Published in
Clinical Research in Cardiology / Issue 8/2015
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI
https://doi.org/10.1007/s00392-015-0839-y

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