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Published in: Clinical Research in Cardiology 4/2010

01-04-2010 | Original Paper

Glycoprotein VI as a prognostic biomarker for cardiovascular death in patients with symptomatic coronary artery disease

Authors: Boris Bigalke, Konstantinos Stellos, Tobias Geisler, Stephan Lindemann, Andreas E. May, Meinrad Gawaz

Published in: Clinical Research in Cardiology | Issue 4/2010

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Abstract

Background

Platelets play a critical role in arterial thrombosis, acute coronary syndrome (ACS) and stroke. Platelet collagen receptor glycoprotein VI (GPVI) is associated with acute coronary events and a poor clinical outcome.

Methods

Between January 2006 and March 2009, we evaluated 2,213 consecutive patients in a prospective study design, who presented with chest pain. Among 1,819 patients (82.2%) who underwent coronary angiography, 1,652 patients (90.8%) showed a coronary and 167 patients (9.2%) a non-coronary origin of chest pain. 901 patients (54.5%) presented with an ACS, 751 (45.5%) with a stable angina pectoris. Clinical outcome was performed by a predefined structured telephone interview after a 3-month follow-up (92.8%:1,533 of 1,652 patients).

Results

Kaplan–Meier analysis for cumulative event-free survival revealed that patients with a elevated baseline GPVI expression had a poorer clinical outcome for cardiovascular death than patients with decreased GPVI levels (log rank; P = 0.040). These results were paralleled in composite cumulative survival that included myocardial infarction, stroke, and cardiovascular death (log rank; P = 0.002). Relative risk of cardiovascular death was found at 1.41 (95% CI 1.08–1.85) for platelet GPVI, 1.64 (95% CI 1.31–2.05) for brain natriuretic peptide, 1.16 (95% CI 0.81–1.64) for troponin-I and 1.33 (95% CI 0.97–1.82) for C-reactive protein.

Conclusions

Patients with CAD presenting increased levels of platelet GPVI had a poorer outcome and may profit from a dual antiplatelet therapy. Thus, GPVI may be a useful prognostic tool for adverse cardiovascular events. Future studies should substantiate GPVI for its potential role of risk prediction and consider its prognostic value to improve risk stratification.
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Metadata
Title
Glycoprotein VI as a prognostic biomarker for cardiovascular death in patients with symptomatic coronary artery disease
Authors
Boris Bigalke
Konstantinos Stellos
Tobias Geisler
Stephan Lindemann
Andreas E. May
Meinrad Gawaz
Publication date
01-04-2010
Publisher
Springer-Verlag
Published in
Clinical Research in Cardiology / Issue 4/2010
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI
https://doi.org/10.1007/s00392-009-0109-y

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