Top

Published in:

01-11-2008 | EDITORIAL

Cardiac positron emission tomography: myocardial perfusion and metabolism in clinical practice

Authors: Paul Knaapen, MD, PhD, Mark Lubberink, PhD

Published in: Clinical Research in Cardiology | Issue 11/2008

Excerpt

Positron emission tomography (PET) is the unrivalled imaging modality to quantitatively and noninvasively track biochemical pathways and study pharmacological mechanisms in vivo. Although the value of cardiac PET has been firmly established in research settings for over two decades, its role in the clinical arena has till recently remained small scaled owing to its limited availability, high costs, and technical demands. The number of cardiac PET centers, however, is steadily increasing and the development of hybrid imaging systems, such as PET/CT, that allow for simultaneous assessment of anatomy and metabolism, has given the clinical potential of cardiac PET a major boost. …

Allman KC, Shaw LJ, Hachamovitch R, Udelson JE (2002) Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis. J Am Coll Cardiol 39(7):1151–1158PubMedCrossRef

Ashrafian H, Frenneaux MP, Opie LH (2007) Metabolic mechanisms in heart failure. Circulation 116(4):434–448PubMedCrossRef

Bax JJ, Poldermans D, Elhendy A, Boersma E, Rahimtoola SH (2001) Sensitivity, specificity, and predictive accuracies of various noninvasive techniques for detecting hibernating myocardium. Curr Probl Cardiol 26(2):147–186PubMedCrossRef

Beanlands RS, Chow BJ, Dick A, Friedrich MG, Gulenchyn KY, Kiess M et al. (2007) CCS/CAR/CANM/CNCS/CanSCMR joint position statement on advanced noninvasive cardiac imaging using positron emission tomography, magnetic resonance imaging and multidetector computed tomographic angiography in the diagnosis and evaluation of ischemic heart disease–executive summary. Can J Cardiol 23(2):107–119PubMed

Bengel FM, Schwaiger M (2004) Assessment of cardiac sympathetic neuronal function using PET imaging. J Nucl Cardiol 11(5):603–616PubMedCrossRef

Camici PG (2000) Positron emission tomography and myocardial imaging. Heart 83(4):475–480PubMedCrossRef

Camici PG, Crea F (2007) Coronary microvascular dysfunction. N Engl J Med 356(8):830–840PubMedCrossRef

Chareonthaitawee P, Kaufmann PA, Rimoldi O, Camici PG (2001) Heterogeneity of resting and hyperemic myocardial blood flow in healthy humans. Cardiovasc Res 50(1):151–161PubMedCrossRef

Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J et al. (2005) EANM/ESC procedural guidelines for myocardial perfusion imaging in nuclear cardiology. Eur J Nucl Med Mol Imaging 32(7):855–897PubMedCrossRef

10.

Iida H, Kanno I, Takahashi A, Miura S, Murakami M, Takahashi K et al. (1988) Measurement of absolute myocardial blood flow with H₂ ¹⁵O and dynamic positron-emission tomography. Strategy for quantification in relation to the partial-volume effect. Circulation 78(1):104–115PubMed

11.

Inubushi M, Tamaki N (2007) Radionuclide reporter gene imaging for cardiac gene therapy. Eur J Nucl Med Mol Imaging 34(suppl 1):S27–S33PubMedCrossRef

12.

Kaufmann PA, Camici PG (2005) Myocardial blood flow measurement by PET: technical aspects and clinical applications. J Nucl Med 46(1):75–88PubMed

13.

Knaapen P, Boellaard R, Gotte MJ, van der Weerdt AP, Visser CA, Lammertsma AA et al. (2003) The perfusable tissue index: a marker of myocardial viability. J Nucl Cardiol 10(6):684–691PubMedCrossRef

14.

Knaapen P, Germans T, Knuuti J, Paulus WJ, Dijkmans PA, Allaart CP et al. (2007) Myocardial energetics and efficiency: current status of the noninvasive approach. Circulation 115(7):918–927PubMedCrossRef

15.

Lee SI, Miller JC, Abbara S, Achenbach S, Jang IK, Thrall JH et al. (2006) Coronary CT angiography. J Am Coll Radiol 3(7):560–564PubMedCrossRef

16.

Marcus ML, Chilian WM, Kanatsuka H, Dellsperger KC, Eastham CL, Lamping KG (1990) Understanding the coronary circulation through studies at the microvascular level. Circulation 82(1):1–7PubMed

17.

Schwaiger M, Ziegler S, Nekolla SG (2005) PET/CT: challenge for nuclear cardiology. J Nucl Med 46(10):1664–1678PubMed

18.

Tillisch J, Brunken R, Marshall R, Schwaiger M, Mandelkern M, Phelps M et al. (1986) Reversibility of cardiac wall-motion abnormalities predicted by positron tomography. N Engl J Med 314(14):884–888PubMed

19.

Underwood SR, Bax JJ, vom Dahl J, Henein MY, Knuuti J, van Rossum AC et al. (2004) Imaging techniques for the assessment of myocardial hibernation. Report of a study group of the European society of cardiology. Eur Heart J 25(10):815–836PubMedCrossRef

20.

Wu JC, Bengel FM, Gambhir SS (2007) Cardiovascular molecular imaging. Radiology 244(2):337–355PubMedCrossRef

21.

deKemp RA, Yoshinaga K, Beanlands RS (2007) Will 3-dimensional PET-CT enable the routine quantification of myocardial blood flow? J Nucl Cardiol 14(3):380–397PubMedCrossRef

Title: Cardiac positron emission tomography: myocardial perfusion and metabolism in clinical practice
Authors: Paul Knaapen, MD, PhD
Mark Lubberink, PhD
Publication date: 01-11-2008
Publisher: D. Steinkopff-Verlag
Published in: Clinical Research in Cardiology / Issue 11/2008
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-008-0662-9

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The STEP trials

Springer Medicine

Cardiac positron emission tomography: myocardial perfusion and metabolism in clinical practice

Excerpt

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The STEP trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 11/2008

Reversible clopidogrel resistance due to right ventricular myocardial infarction: risk factor of recurrent stent thrombosis?

Covered rupture of the free left ventricular wall or “only” thrombus in a true aneurysm?

Acute hemodynamic effects of intravenous amiodarone treatment in paediatric cardiac surgical patients

Combined Impella and intra-aortic ballon pump support to improve macro- and microcirculation: a clinical case

Low night-to-night variability of sleep disordered breathing in patients with stable congestive heart failure

Levosimendan for bridging in a pediatric patient with Alström syndrome awaiting heart-lung transplantation

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page