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International Journal of Colorectal Disease

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01-06-2021 | Rectal Cancer | Original Article

Treatment and subsequent prognosis in locally recurrent rectal cancer: a multicenter retrospective study of 498 patients

Authors: Takatoshi Matsuyama, Shinichi Yamauchi, Taiki Masuda, Akifumi Kikuchi, Masanori Tokunaga, Kenichi Sugihara, Yusuke Kinugasa, Japanese Study Group for Postoperative Follow-up of Colorectal Cancer

Published in: International Journal of Colorectal Disease | Issue 6/2021

Abstract

Purpose

Locally recurrent rectal cancer (LRRC) has a tremendous impact on prognosis as well as the quality of life. Because of the low incidence and various recurrence patterns, the treatment outcome of LRRC is not fully elucidated. The current study aimed to evaluate the prognosis and identify the prognosticators in patients with LRRC.

Methods

We conducted a multicenter study at 24 hospitals in Japan. Patients with primary rectal cancer who underwent curative resection between 1997 and 2012 and developed local recurrence only as a first recurrent event were recruited. The primary outcome of our study was overall survival (OS) after a diagnosis of LRRC.

Results

Four hundred and ninety-eight patients were included in the study. Of these, 213 (42.8%) underwent surgical resection; this was associated with the best 5-year OS rate of 52%, followed by carbon ion/proton therapy (44%). Among LRRC patients, undifferentiated type, T4, high CEA level, and high CA19–9 level were independent prognosticators of OS (hazard ratio (HR) = 1.83, P = 0.008, HR = 1.54, P = 0.004, HR = 1.35, P = 0.03, and HR = 1.58, P = 0.003, respectively).

Conclusions

This large-scale cohort study showed that surgical resection led to a favorable prognosis compared to other treatments for LRRC. Therefore, surgical resection should be considered whenever feasible for LRRC patients. In addition, undifferentiated type, T4, and tumor marker (CEA and CA19–9) elevation were identified as independent prognostic factors for OS among patients with LRRC.

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Title: Treatment and subsequent prognosis in locally recurrent rectal cancer: a multicenter retrospective study of 498 patients
Authors: Takatoshi Matsuyama
Shinichi Yamauchi
Taiki Masuda
Akifumi Kikuchi
Masanori Tokunaga
Kenichi Sugihara
Yusuke Kinugasa
Japanese Study Group for Postoperative Follow-up of Colorectal Cancer
Publication date: 01-06-2021
Publisher: Springer Berlin Heidelberg
Keywords: Rectal Cancer
Rectal Cancer
Cancer Biomarker
Published in: International Journal of Colorectal Disease / Issue 6/2021
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-021-03856-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Treatment and subsequent prognosis in locally recurrent rectal cancer: a multicenter retrospective study of 498 patients

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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