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International Journal of Colorectal Disease

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01-01-2020 | Colorectal Cancer | Original Article

Significance of the 7th postoperative day neutrophil-to-lymphocyte ratio in colorectal cancer

Authors: Tamuro Hayama, Yojiro Hashiguchi, Yuka Okada, Kohei Ono, Kentaro Nemoto, Ryu Shimada, Tsuyoshi Ozawa, Tetsutaka Toyoda, Takeshi Tsuchiya, Hisae Iinuma, Keijiro Nozawa, Keiji Matsuda

Published in: International Journal of Colorectal Disease | Issue 1/2020

Abstract

Purpose

High neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation and is associated with poor survival in localized or metastatic cancer. Preoperative NLR in colorectal cancer reportedly correlates with recurrence-free survival and is useful as a recurrence prediction factor. No reports have yet investigated recurrence factors using postoperative NLR. This study assessed the predictive value of NLR preoperatively and on the first (NLR1) and seventh day (NLR7) postoperatively in patients with stage II colorectal cancer.

Methods

We performed a retrospective cohort study involving patients undergoing colorectal resection at a single institution between January 2012 and December 2016; we used medical records of 176 consecutive patients with stage II colorectal cancer undergoing curative tumor resection. NLRs as well as clinical, histopathologic, and laboratory data were analyzed. Univariate and multivariate analyses were conducted to identify prognostic factors associated with recurrence-free survival (RFS).

Results

Univariate analysis revealed that elevated NLR, NLR7, and lymphatic invasion were significantly associated with decreased RFS (p < 0.05). NLR7 was revealed as significant via multivariate analysis (p = 0.013). The 3-year RFS rate was 87.1% for patients with normal NLR7 and 70.3% for those with elevated NLR7.

Conclusion

Elevated seventh-day postoperative NLR is a significant independent predictor of reduced RFS for patients with stage II colorectal cancer and may be a potential biomarker for identifying candidates for adjuvant chemotherapy.

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Title: Significance of the 7th postoperative day neutrophil-to-lymphocyte ratio in colorectal cancer
Authors: Tamuro Hayama
Yojiro Hashiguchi
Yuka Okada
Kohei Ono
Kentaro Nemoto
Ryu Shimada
Tsuyoshi Ozawa
Tetsutaka Toyoda
Takeshi Tsuchiya
Hisae Iinuma
Keijiro Nozawa
Keiji Matsuda
Publication date: 01-01-2020
Publisher: Springer Berlin Heidelberg
Keywords: Colorectal Cancer
Colorectal Cancer
Published in: International Journal of Colorectal Disease / Issue 1/2020
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-019-03463-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Significance of the 7th postoperative day neutrophil-to-lymphocyte ratio in colorectal cancer

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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