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International Journal of Colorectal Disease

Published in:

01-04-2017 | Original Article

Multiple behavioral factors are associated with occurrence of large, flat colorectal polyps

Authors: Tianzuo Zhan, Felix Hahn, Thomas Hielscher, Asmé Bilge, Jürgen Grüger, Jürgen Weers, Johannes Betge, Timo Gaiser, Georg Kähler, Matthias P. Ebert, Sebastian Belle

Published in: International Journal of Colorectal Disease | Issue 4/2017

Abstract

Purpose

The prevalence of advanced dysplasia and synchronous lesions is particularly high in patients with large, flat colorectal polyps. However, the impact of lifestyle on the development of such polyps is poorly investigated. Hence, this study aims to identify associations between behavioral factors and the occurrence of large, flat colorectal polyps.

Methods

Behavioral factors were retrospectively analyzed in patients with large, flat polyps and control patients with at most one diminutive polyp. Information on lifestyle factors, comorbidities, and demographic parameters were determined by a structured, self-administered questionnaire.

Results

Questionnaires of 350 patients with large, flat polyps and 489 control patients were included in the analysis. Most large, flat colorectal polyps contained adenoma with low-grade neoplasia and were located in the right colon. Multivariate analysis showed that advanced age (per 1-year increase—OR 1.09, CI 1.07–1.11, p < 0.0001), frequent cigarette smoking (OR 2.04, CI 1.25–3.32, p = 0.0041), daily consumption of red meat (OR 3.61, CI 1.00–12.96, p = 0.0492), and frequent bowel movements (OR 1.62, CI 1.13–2.33, p = 0.0093) were independent risk factors for occurrence of large, flat colorectal polyps. In contrast, frequent intake of cereals (OR 0.62, CI 0.44–0.88, p = 0.0074) was associated with a reduced risk.

Conclusion

Multiple behavioral factors modulate the risk for developing large, flat colorectal polyps. This knowledge can be used to improve prevention of colorectal cancer.

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Title: Multiple behavioral factors are associated with occurrence of large, flat colorectal polyps
Authors: Tianzuo Zhan
Felix Hahn
Thomas Hielscher
Asmé Bilge
Jürgen Grüger
Jürgen Weers
Johannes Betge
Timo Gaiser
Georg Kähler
Matthias P. Ebert
Sebastian Belle
Publication date: 01-04-2017
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Colorectal Disease / Issue 4/2017
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-016-2717-0

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Multiple behavioral factors are associated with occurrence of large, flat colorectal polyps

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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