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International Journal of Colorectal Disease

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Open Access 01-08-2012 | Original Article

Survival following laparoscopic versus open resection for colorectal cancer

Authors: Wai Lun Law, Jensen T. C. Poon, Joe K. M. Fan, Oswens S. H. Lo

Published in: International Journal of Colorectal Disease | Issue 8/2012

Abstract

Background

This study aimed to compare the overall and disease specific survivals of patients who underwent laparoscopic and open resection of colorectal cancer in a high volume tertiary center.

Methods

Consecutive patients who underwent elective resection for colorectal cancer (open resection, n = 1,197; laparoscopic resection, n = 814) from January 2000 to December 2009 were included. The operative details, postoperative complications, postoperative outcomes, and survival data were collected prospectively. Comparison was made between patients who had laparoscopic and open surgery.

Results

The age, gender, medical morbidity, and American Society of Anesthesiologists status were similar in the two groups. Laparoscopic resection was associated with significantly less blood loss and a shorter hospital stay. The operating mortality and morbidity were significantly lower in the laparoscopic group. The qualities of the specimens in terms of the distal resection margin and the number of lymph nodes examined were not inferior in the laparoscopic group. With the median follow-up of 40.3 months, the 5-year overall survival (74.1% vs. 65.5%, p < 0.001) and disease specific survival (81.9% vs. 75.2%, p = 0.002) were significantly better in patients with non-disseminated disease in the laparoscopic group. The operative approach was an independent prognostic factor in the overall (risk ratio 1.36, 95% CI 1.093–1.700, p = 0.006) and disease specific (risk ratio 1.32, 95% CI 1.005–1.738, p = 0.048) survivals in multivariate analysis.

Conclusion

Laparoscopic resection for colorectal cancer is associated with more favorable overall and disease specific survivals when compared with open resection in a high volume tertiary center.

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Title: Survival following laparoscopic versus open resection for colorectal cancer
Authors: Wai Lun Law
Jensen T. C. Poon
Joe K. M. Fan
Oswens S. H. Lo
Publication date: 01-08-2012
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 8/2012
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-012-1424-8

At a glance: The STEP trials

Springer Medicine

Survival following laparoscopic versus open resection for colorectal cancer

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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