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International Journal of Colorectal Disease

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01-08-2012 | Original Article

PLA2G4A mutants modified protective effect of tea consumption against colorectal cancer

Authors: Yunxian Yu, Mingwu Zhang, Yifeng Pan, Mingjuan Jin, Xia Jiang, Shanchun Zhang, Yinyin Wu, Qun Ni, Qilong Li, Kun Chen

Published in: International Journal of Colorectal Disease | Issue 8/2012

Abstract

Purpose

The primary aim was to respectively evaluate PLA2G4A mutants modifying protective effect of tea consumption against colorectal cancer (CRC), colon and rectal cancer.

Methods

All participants were recruited from January 2006 to April 2008. The information about tea consumption was collected by a structured questionnaire. CRC patients were diagnosed based on histology. Four single-nuclear polymorphisms (SNPs) in PLA2G4A gene were selected. Multiple logistic regression models were used for assessing the joint effects between tea consumption and SNPs on CRC, colon and rectal cancer.

Results

Three hundred patients with CRC and 296 controls well-matched were used in the final analyses. The significant individual associations between four SNPs (rs6666834, rs10911933, rs4650708 and rs7526089) and CRC were not observed. However, their CTAC haplotype was significantly associated with the increased risk of CRC (OR = 3.06; 95%CI = 1.52–6.19), compared with TCAC haplotype. Drinking tea was correlated with a decreased risk of CRC after adjustment for covariates (OR = 0.61; 95%CI = 0.39–0.97). Meanwhile, compared with no-tea drinkers with TT/CT genotype of rs6666834, tea drinkers with TT/CT or CC had significant lower risk of CRC (OR = 0.6, 95%CI = 0.36–1.00 for TT/CT; 0.38, 0.19–0.74 for CC). The joint effects between the remaining three SNPs and drinking tea on CRC were observed as well. Similar findings were observed on colon and rectal cancers.

Conclusions

Tea consumption and haplotype of mutants in PLA2G4A gene were respectively associated with the risk of CRC. PLA2G4A mutants modified the protective effect of tea consumption against CRC, colon and rectal cancers in Chinese population.

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Title: PLA2G4A mutants modified protective effect of tea consumption against colorectal cancer
Authors: Yunxian Yu
Mingwu Zhang
Yifeng Pan
Mingjuan Jin
Xia Jiang
Shanchun Zhang
Yinyin Wu
Qun Ni
Qilong Li
Kun Chen
Publication date: 01-08-2012
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 8/2012
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-012-1417-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

PLA2G4A mutants modified protective effect of tea consumption against colorectal cancer

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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