Skip to main content
Top
Published in: International Journal of Colorectal Disease 3/2012

01-03-2012 | Original Article

Gender differences in colorectal cancer during the past 20 years in Taiwan

Authors: Tzu-An Chen, Hsiao-Yen Kang, Huan-Cheng Chang, Wen-Chu Lin, Tsung-Ming Chao, Jorng-Tzong Horng

Published in: International Journal of Colorectal Disease | Issue 3/2012

Login to get access

Abstract

Purpose

Gender differences in colorectal cancer (CRC) incidence have been previously reported. We designed this population-based study to determine if this gender difference was restricted to specific patient subgroups.

Methods

Using the Taiwan Cancer Registry database, we identified a total of 124,314 CRCs registered from 1988 to 2007. We compared the incidence of CRCs by gender in all CRCs, in colon and rectal cancers considered separately, and in right-sided versus left-sided colon cancers.

Results

In individuals aged 50 years and older, the incidence of CRCs was lower in females compared with males. For right-sided colon cancers, the incidence in both genders was similar. Because the proportion of right-sided colon cancer accounted for only one fourth of the total CRCs, its influence on the incidence of total CRCs is reduced.

Conclusions

Although the incidence of total CRCs is male dominant, the actual gender difference in CRC incidence in Taiwan is limited to the left side of the colon.
Appendix
Available only for authorised users
Literature
1.
go back to reference Altekruse SF, Kosary CL, Krapcho M, Neyman N, Aminou R, Waldron W, Ruhl J, Howlader N, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Cronin K, Chen HS, Feuer EJ, Stinchcomb DG, Edwards BK (eds) SEER Cancer Statistics Review, 1975–2007. National Cancer Institute, Bethesda. Available at http://seer.cancer.gov/csr/1975_2007/, based on November 2009 SEER data submission, posted to the SEER web site, 2010 Altekruse SF, Kosary CL, Krapcho M, Neyman N, Aminou R, Waldron W, Ruhl J, Howlader N, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Cronin K, Chen HS, Feuer EJ, Stinchcomb DG, Edwards BK (eds) SEER Cancer Statistics Review, 1975–2007. National Cancer Institute, Bethesda. Available at http://​seer.​cancer.​gov/​csr/​1975_​2007/​, based on November 2009 SEER data submission, posted to the SEER web site, 2010
2.
go back to reference Ratto C, Sofo L, Ippoliti M, Merico M, Doglietto GB, Crucitti F (1998) Prognostic factors in colorectal cancer. Literature review for clinical application. Dis Colon Rectum 41:1033–1049PubMedCrossRef Ratto C, Sofo L, Ippoliti M, Merico M, Doglietto GB, Crucitti F (1998) Prognostic factors in colorectal cancer. Literature review for clinical application. Dis Colon Rectum 41:1033–1049PubMedCrossRef
3.
go back to reference McArdle CS, McMillan DC, Hole DJ (2003) Male gender adversely affects survival following surgery for colorectal cancer. Br J Surg 90:711–715PubMedCrossRef McArdle CS, McMillan DC, Hole DJ (2003) Male gender adversely affects survival following surgery for colorectal cancer. Br J Surg 90:711–715PubMedCrossRef
4.
go back to reference Wichmann MW, Muller C, Hornung HM, Lau-Werner U, Schildberg FW, Colorectal Cancer Study Group (2001) Gender differences in long-term survival of patients with colorectal cancer. Br J Surg 88:1092–1098PubMedCrossRef Wichmann MW, Muller C, Hornung HM, Lau-Werner U, Schildberg FW, Colorectal Cancer Study Group (2001) Gender differences in long-term survival of patients with colorectal cancer. Br J Surg 88:1092–1098PubMedCrossRef
5.
go back to reference Wilkins HR, Doucet K, Duke V, Morra A, Johnson N (2010) Estrogen prevents sustained COLO-205 human colon cancer cell growth by inducing apoptosis, decreasing c-myb protein, and decreasing transcription of the anti-apoptotic protein bcl-2. Tumor Biol 31:16–22CrossRef Wilkins HR, Doucet K, Duke V, Morra A, Johnson N (2010) Estrogen prevents sustained COLO-205 human colon cancer cell growth by inducing apoptosis, decreasing c-myb protein, and decreasing transcription of the anti-apoptotic protein bcl-2. Tumor Biol 31:16–22CrossRef
6.
go back to reference Koo JH, Jalaludin B, Wong SK, Kneebone A, Connor SJ, Leong RW (2008) Improved survival in young women with colorectal cancer. Am J Gastroenterol 103:1488–1495PubMedCrossRef Koo JH, Jalaludin B, Wong SK, Kneebone A, Connor SJ, Leong RW (2008) Improved survival in young women with colorectal cancer. Am J Gastroenterol 103:1488–1495PubMedCrossRef
7.
go back to reference Koo JH, Leong RW (2010) Sex differences in epidemiological, clinical and pathological characteristics of colorectal cancer. J Gastroenterol Hepatol 25:33–42PubMedCrossRef Koo JH, Leong RW (2010) Sex differences in epidemiological, clinical and pathological characteristics of colorectal cancer. J Gastroenterol Hepatol 25:33–42PubMedCrossRef
8.
go back to reference CDeCosse JJ, Ngoi S-S, Jacobson JS, Cennerazzo WJ (1993) Gender and colorectal cancer. Eur J Cancer Prev 2:105–115CrossRef CDeCosse JJ, Ngoi S-S, Jacobson JS, Cennerazzo WJ (1993) Gender and colorectal cancer. Eur J Cancer Prev 2:105–115CrossRef
9.
go back to reference Bufill JA (1990) Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location. Ann Intern Med 113:779–788PubMed Bufill JA (1990) Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location. Ann Intern Med 113:779–788PubMed
10.
11.
go back to reference Gonzalez EC, Roetzheim RG, Ferrante JM, Campbell R (2001) Predictors of proximal vs. distal colorectal cancers. Dis Colon Rectum 44:251–258PubMedCrossRef Gonzalez EC, Roetzheim RG, Ferrante JM, Campbell R (2001) Predictors of proximal vs. distal colorectal cancers. Dis Colon Rectum 44:251–258PubMedCrossRef
12.
go back to reference Larsson SC, Rafter J, Holmberg L, Bergkvist L, Wolk A (2005) Red meat consumption and risk of cancers of the proximal colon, distal colon and rectum: the Swedish Mammography Cohort. Int J Cancer 113:829–834PubMedCrossRef Larsson SC, Rafter J, Holmberg L, Bergkvist L, Wolk A (2005) Red meat consumption and risk of cancers of the proximal colon, distal colon and rectum: the Swedish Mammography Cohort. Int J Cancer 113:829–834PubMedCrossRef
13.
go back to reference Chao A, Thun MJ, Connell CJ et al (2005) Meat consumption and risk of colorectal cancer. JAMA 293:172–182PubMedCrossRef Chao A, Thun MJ, Connell CJ et al (2005) Meat consumption and risk of colorectal cancer. JAMA 293:172–182PubMedCrossRef
14.
go back to reference Toyomura K, Yamaguchi K, Kawamoto H et al (2004) Relation of cigarette smoking and alcohol use to colorectal adenomas by subsite: the self-defense forces health study. Cancer Sci 95:72–76PubMedCrossRef Toyomura K, Yamaguchi K, Kawamoto H et al (2004) Relation of cigarette smoking and alcohol use to colorectal adenomas by subsite: the self-defense forces health study. Cancer Sci 95:72–76PubMedCrossRef
15.
go back to reference Sharpe CR, Siemiatycki J, Rachet B (2002) Effects of alcohol consumption on the risk of colorectal cancer among men by anatomical subsite (Canada). Cancer Causes Control 13:483–491PubMedCrossRef Sharpe CR, Siemiatycki J, Rachet B (2002) Effects of alcohol consumption on the risk of colorectal cancer among men by anatomical subsite (Canada). Cancer Causes Control 13:483–491PubMedCrossRef
16.
go back to reference Russo A, Franceschi S, La Vecchia C et al (1998) Body size and colorectal-cancer risk. Int J Cancer 78:161–165PubMedCrossRef Russo A, Franceschi S, La Vecchia C et al (1998) Body size and colorectal-cancer risk. Int J Cancer 78:161–165PubMedCrossRef
17.
go back to reference Meyerhardt JA, Catalano PJ, Haller DG et al (2003) Influence of body mass index on outcomes and treatment-related toxicity in patients with colon carcinoma. Cancer 98:484–495PubMedCrossRef Meyerhardt JA, Catalano PJ, Haller DG et al (2003) Influence of body mass index on outcomes and treatment-related toxicity in patients with colon carcinoma. Cancer 98:484–495PubMedCrossRef
18.
go back to reference de Kok IM, Wong CS, Chia KS (2008) Gender differences in the trend of colorectal cancer incidence in Singapore, 1968–2002. Int J Colorectal Dis 23:461–467PubMedCrossRef de Kok IM, Wong CS, Chia KS (2008) Gender differences in the trend of colorectal cancer incidence in Singapore, 1968–2002. Int J Colorectal Dis 23:461–467PubMedCrossRef
19.
go back to reference Tsai YW, Tsai TI, Yang CL, Kuo KN (2008) Gender differences in smoking behaviors in an Asian population. J Womens Health (Larchmt) 17:971–978CrossRef Tsai YW, Tsai TI, Yang CL, Kuo KN (2008) Gender differences in smoking behaviors in an Asian population. J Womens Health (Larchmt) 17:971–978CrossRef
20.
go back to reference Liu CS, Hsu HS, Li CI et al (2010) Central obesity and atherogenic dyslipidemia in metabolic syndrome are associated with increased risk for colorectal adenoma in a Chinese population. BMC Gastroenterol 10:51PubMedCrossRef Liu CS, Hsu HS, Li CI et al (2010) Central obesity and atherogenic dyslipidemia in metabolic syndrome are associated with increased risk for colorectal adenoma in a Chinese population. BMC Gastroenterol 10:51PubMedCrossRef
21.
go back to reference Brenner H, Hoffmeister M, Arndt V, Haug U (2007) Gender differences in colorectal cancer: implications for age at initiation of screening. Br J Cancer 96:828–831PubMedCrossRef Brenner H, Hoffmeister M, Arndt V, Haug U (2007) Gender differences in colorectal cancer: implications for age at initiation of screening. Br J Cancer 96:828–831PubMedCrossRef
22.
go back to reference Winawer SJ, Zauber AG, Ho MN et al (1993) Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med 329:1977–1981PubMedCrossRef Winawer SJ, Zauber AG, Ho MN et al (1993) Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med 329:1977–1981PubMedCrossRef
23.
go back to reference Regula J, Rupinski M, Kraszewska E et al (2006) Colonoscopy in colorectal cancer screening for detection of advanced neoplasia. N Engl J Med 355:1863–1872PubMedCrossRef Regula J, Rupinski M, Kraszewska E et al (2006) Colonoscopy in colorectal cancer screening for detection of advanced neoplasia. N Engl J Med 355:1863–1872PubMedCrossRef
24.
go back to reference Chow SN, Huang CC, Lee YT (1997) Demographic characteristics and medical aspects of menopausal women in Taiwan. J Formos Med Assoc 96:806–811PubMed Chow SN, Huang CC, Lee YT (1997) Demographic characteristics and medical aspects of menopausal women in Taiwan. J Formos Med Assoc 96:806–811PubMed
Metadata
Title
Gender differences in colorectal cancer during the past 20 years in Taiwan
Authors
Tzu-An Chen
Hsiao-Yen Kang
Huan-Cheng Chang
Wen-Chu Lin
Tsung-Ming Chao
Jorng-Tzong Horng
Publication date
01-03-2012
Publisher
Springer-Verlag
Published in
International Journal of Colorectal Disease / Issue 3/2012
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-011-1318-1

Other articles of this Issue 3/2012

International Journal of Colorectal Disease 3/2012 Go to the issue